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Items: 1 to 20 of 23


Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.

Taher TE, Bystrom J, Ong VH, Isenberg DA, Renaudineau Y, Abraham DJ, Mageed RA.

Clin Rev Allergy Immunol. 2017 Oct;53(2):237-264. doi: 10.1007/s12016-017-8609-4. Review.


IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.

Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J.

J Immunol. 2017 Mar 15;198(6):2445-2456. doi: 10.4049/jimmunol.1601453. Epub 2017 Feb 3.


Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.

Gasparrini F, Feest C, Bruckbauer A, Mattila PK, Müller J, Nitschke L, Bray D, Batista FD.

EMBO J. 2016 Feb 1;35(3):258-80. doi: 10.15252/embj.201593027. Epub 2015 Dec 15.


An extracatalytic function of CD45 in B cells is mediated by CD22.

Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6515-24. doi: 10.1073/pnas.1519925112. Epub 2015 Nov 11.


Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.

Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML.

J Immunol. 2015 Apr 15;194(8):3675-86. doi: 10.4049/jimmunol.1500026. Epub 2015 Mar 13.


Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.

Kleiman E, Salyakina D, De Heusch M, Hoek KL, Llanes JM, Castro I, Wright JA, Clark ES, Dykxhoorn DM, Capobianco E, Takeda A, Renauld JC, Khan WN.

Front Immunol. 2015 Feb 11;6:30. doi: 10.3389/fimmu.2015.00030. eCollection 2015. Erratum in: Front Immunol. 2016;7:267.


Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL.

J Immunol. 2014 Feb 1;192(3):875-85. doi: 10.4049/jimmunol.1300683. Epub 2013 Dec 30.


Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.

Caignard G, Leiva-Torres GA, Leney-Greene M, Charbonneau B, Dumaine A, Fodil-Cornu N, Pyzik M, Cingolani P, Schwartzentruber J, Dupaul-Chicoine J, Guo H, Saleh M, Veillette A, Lathrop M, Blanchette M, Majewski J, Pearson A, Vidal SM.

PLoS Pathog. 2013 Sep;9(9):e1003637. doi: 10.1371/journal.ppat.1003637. Epub 2013 Sep 12.


The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Zikherman J, Parameswaran R, Hermiston M, Weiss A.

J Immunol. 2013 Mar 15;190(6):2527-35. doi: 10.4049/jimmunol.1202928. Epub 2013 Feb 8.


Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.

Tonks NK.

FEBS J. 2013 Jan;280(2):346-78. doi: 10.1111/febs.12077. Epub 2013 Jan 17. Review.


Endogenous antigen tunes the responsiveness of naive B cells but not T cells.

Zikherman J, Parameswaran R, Weiss A.

Nature. 2012 Sep 6;489(7414):160-4. doi: 10.1038/nature11311.


Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.

Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):E3-12. doi: 10.1073/pnas.1117374108. Epub 2011 Nov 30.


Lyn deficiency affects B-cell maturation as well as survival.

Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R.

Eur J Immunol. 2012 Feb;42(2):511-21. doi: 10.1002/eji.201141940. Epub 2011 Dec 14.


CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A.

Immunity. 2010 Mar 26;32(3):342-54. doi: 10.1016/j.immuni.2010.03.006.


Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.

Stanford SM, Mustelin TM, Bottini N.

Semin Immunopathol. 2010 Jun;32(2):127-36. doi: 10.1007/s00281-010-0201-4. Epub 2010 Mar 4. Review.


The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism.

Hofmeyer K, Treisman JE.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19399-404. doi: 10.1073/pnas.0903961106. Epub 2009 Nov 4.


PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A.

J Immunol. 2009 Apr 1;182(7):4093-106. doi: 10.4049/jimmunol.0803317.


CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells.

Hermiston ML, Zikherman J, Zhu JW.

Immunol Rev. 2009 Mar;228(1):288-311. doi: 10.1111/j.1600-065X.2008.00752.x. Review. Erratum in: Immunol Rev. 2009 May;229(1):387.


Antigen receptor signaling in the rheumatic diseases.

Zikherman J, Weiss A.

Arthritis Res Ther. 2009;11(1):202. doi: 10.1186/ar2528. Epub 2009 Jan 30. Review.


Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.

Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):546-51. doi: 10.1073/pnas.0811647106. Epub 2009 Jan 7.

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