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Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation.

Zhang R, Huang SY, Ka-Wai Li K, Li YH, Hsu WH, Zhang GJ, Chang CJ, Yang JY.

Oncotarget. 2017 Jul 25;8(30):49869-49881. doi: 10.18632/oncotarget.17769.


Multisystem Involvement in a Patient with a PTCH1 Mutation: Clinical and Imaging Findings.

Richieri-Costa A, Vendramini-Pittoli S, Kokitsu-Nakata NM, Zechi-Ceide RM, Alvarez CW, Ribeiro-Bicudo LA.

J Pediatr Genet. 2017 Jun;6(2):103-106. doi: 10.1055/s-0036-1588028. Epub 2016 Sep 14.


Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway.

Zhou F, Huang D, Li Y, Hu G, Rao H, Lu Q, Luo S, Wang Y.

Int J Oncol. 2017 Feb;50(2):373-380. doi: 10.3892/ijo.2016.3819. Epub 2016 Dec 23.


Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling.

Liu X, Shen Q, Yu T, Huang H, Zhang Z, Ding J, Tang Y, Xu N, Yue S.

Cell Biosci. 2016 Dec 12;6:61. doi: 10.1186/s13578-016-0126-2. eCollection 2016.


Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.

Infante P, Alfonsi R, Ingallina C, Quaglio D, Ghirga F, D'Acquarica I, Bernardi F, Di Magno L, Canettieri G, Screpanti I, Gulino A, Botta B, Mori M, Di Marcotullio L.

Cell Death Dis. 2016 Sep 22;7(9):e2376. doi: 10.1038/cddis.2016.195.


Evaluation of the 'Hedgehog' signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva.

Celebi AR, Kiratli H, Soylemezoglu F.

Oncol Lett. 2016 Jul;12(1):467-472. Epub 2016 May 25.


Advances in targeted and immunobased therapies for colorectal cancer in the genomic era.

Seow HF, Yip WK, Fifis T.

Onco Targets Ther. 2016 Mar 31;9:1899-920. doi: 10.2147/OTT.S95101. eCollection 2016. Review.


Genetics of Bladder Malignant Tumors in Childhood.

Zangari A, Zaini J, Gulìa C.

Curr Genomics. 2016 Feb;17(1):14-32. doi: 10.2174/1389202916666151014221954.


Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.

Hettmer S, Lin MM, Tchessalova D, Tortorici SJ, Castiglioni A, Desai T, Mao J, McMahon AP, Wagers AJ.

Exp Cell Res. 2016 Jan 1;340(1):43-52. doi: 10.1016/j.yexcr.2015.10.008. Epub 2015 Oct 13.


Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions.

Gu D, Xie J.

Cancers (Basel). 2015 Aug 27;7(3):1684-98. doi: 10.3390/cancers7030857. Review.


Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.

Maschinot CA, Pace JR, Hadden MK.

Curr Med Chem. 2015;22(35):4033-57. Review.


Hedgehog Signaling in the Maintenance of Cancer Stem Cells.

Cochrane CR, Szczepny A, Watkins DN, Cain JE.

Cancers (Basel). 2015 Aug 11;7(3):1554-85. doi: 10.3390/cancers7030851. Review.


Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems.

Kashi VP, Hatley ME, Galindo RL.

Nat Rev Cancer. 2015 Jul;15(7):426-39. doi: 10.1038/nrc3961. Review.


Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

Gonnissen A, Isebaert S, Haustermans K.

Oncotarget. 2015 Jun 10;6(16):13899-913. Review.


Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.

Nitzki F, Tolosa EJ, Cuvelier N, Frommhold A, Salinas-Riester G, Johnsen SA, Fernandez-Zapico ME, Hahn H.

Oncotarget. 2015 Apr 20;6(11):9113-24.


Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions.

Hettmer S, Bronson RT, Wagers AJ.

Front Oncol. 2015 Feb 24;5:50. doi: 10.3389/fonc.2015.00050. eCollection 2015.


The Hedgehog pathway: role in cell differentiation, polarity and proliferation.

Jia Y, Wang Y, Xie J.

Arch Toxicol. 2015 Feb;89(2):179-91. doi: 10.1007/s00204-014-1433-1. Epub 2015 Jan 6. Review.


Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells.

Wang J, Gu S, Huang J, Chen S, Zhang Z, Xu M.

BMC Cancer. 2014 Oct 17;14:768. doi: 10.1186/1471-2407-14-768.


Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma.

Fu W, Asp P, Canter B, Dynlacht BD.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9151-6. doi: 10.1073/pnas.1323265111. Epub 2014 Jun 9.

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