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Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis.

Jeong JH, Yu KS, Bak DH, Lee JH, Lee NS, Jeong YG, Kim DK, Kim JJ, Han SY.

Exp Ther Med. 2016 Nov;12(5):3021-3028.


Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6.

Chan ST, Lee J, Narula M, Ou JJ.

J Virol. 2016 Nov 14;90(23):10928-10935.


Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.

Lin TV, Hsieh L, Kimura T, Malone TJ, Bordey A.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11330-11335.


Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients.

Ahola S, Auranen M, Isohanni P, Niemisalo S, Urho N, Buzkova J, Velagapudi V, Lundbom N, Hakkarainen A, Muurinen T, Piirilä P, Pietiläinen KH, Suomalainen A.

EMBO Mol Med. 2016 Nov 2;8(11):1234-1247. doi: 10.15252/emmm.201606592.


Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.

Park S, Han S, Choi I, Kim B, Park SP, Joe EH, Suh YH.

PLoS One. 2016 Sep 15;11(9):e0163029. doi: 10.1371/journal.pone.0163029.


LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

Hubert V, Peschel A, Langer B, Gröger M, Rees A, Kain R.

Biol Open. 2016 Oct 15;5(10):1516-1529. doi: 10.1242/bio.018648.


The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export.

Port SA, Mendes A, Valkova C, Spillner C, Fahrenkrog B, Kaether C, Kehlenbach RH.

J Biol Chem. 2016 Oct 28;291(44):23068-23083.


Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance.

Guo XD, Sun GL, Zhou TT, Xu X, Zhu ZY, Rukachaisirikul V, Hu LH, Shen X.

Acta Pharmacol Sin. 2016 Sep;37(10):1281-1297. doi: 10.1038/aps.2016.80.


TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.

Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V.

J Cell Sci. 2016 Oct 1;129(19):3562-3573.


The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins.

Jiang Y, Lee J, Lee JH, Lee JW, Kim JH, Choi WH, Yoo YD, Cha-Molstad H, Kim BY, Kwon YT, Noh SA, Kim KP, Lee MJ.

Autophagy. 2016 Nov;12(11):2197-2212.


Autophagy and ubiquitin-proteasome system contribute to sperm mitophagy after mammalian fertilization.

Song WH, Yi YJ, Sutovsky M, Meyers S, Sutovsky P.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5261-70. doi: 10.1073/pnas.1605844113.


Absence of the Autophagy Adaptor SQSTM1/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy.

Haack TB, Ignatius E, Calvo-Garrido J, Iuso A, Isohanni P, Maffezzini C, Lönnqvist T, Suomalainen A, Gorza M, Kremer LS, Graf E, Hartig M, Berutti R, Paucar M, Svenningsson P, Stranneheim H, Brandberg G, Wedell A, Kurian MA, Hayflick SA, Venco P, Tiranti V, Strom TM, Dichgans M, Horvath R, Holinski-Feder E, Freyer C, Meitinger T, Prokisch H, Senderek J, Wredenberg A, Carroll CJ, Klopstock T.

Am J Hum Genet. 2016 Sep 1;99(3):735-43. doi: 10.1016/j.ajhg.2016.06.026.


Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus.

Li X, Liu F, Zhang X, Shi G, Ren J, Ji J, Ding L, Fan H, Dou H, Hou Y.

Cell Death Dis. 2016 Aug 18;7(8):e2341. doi: 10.1038/cddis.2016.244.


Autophagy resolves early retinal inflammation in Igf1-deficient mice.

Arroba AI, Rodríguez-de la Rosa L, Murillo-Cuesta S, Vaquero-Villanueva L, Hurlé JM, Varela-Nieto I, Valverde ÁM.

Dis Model Mech. 2016 Sep 1;9(9):965-74. doi: 10.1242/dmm.026344.


ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.

Gal J, Kuang L, Barnett KR, Zhu BZ, Shissler SC, Korotkov KV, Hayward LJ, Kasarskis EJ, Zhu H.

Acta Neuropathol. 2016 Oct;132(4):563-76. doi: 10.1007/s00401-016-1601-x.


Autophagy is associated with cell fate in the process of macrophage-derived foam cells formation and progress.

Liu X, Tang Y, Cui Y, Zhang H, Zhang D.

J Biomed Sci. 2016 Jul 30;23(1):57. doi: 10.1186/s12929-016-0274-z.


Size, organization, and dynamics of soluble SQSTM1 and LC3-SQSTM1 complexes in living cells.

Kraft LJ, Dowler J, Manral P, Kenworthy AK.

Autophagy. 2016 Sep;12(9):1660-74. doi: 10.1080/15548627.2016.1199299.


Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus.

Lim SW, Jin L, Jin J, Yang CW.

Sci Rep. 2016 Jul 20;6:29921. doi: 10.1038/srep29921.

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