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Items: 9


Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species.

Li Q, Mu Z, Zhao R, Dahal G, Viola RE, Liu T, Jin Q, Cui S.

Sci Rep. 2016 Feb 12;6:21067. doi: 10.1038/srep21067.


Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.

Thangavelu B, Bhansali P, Viola RE.

Bioorg Med Chem. 2015 Oct 15;23(20):6622-31. doi: 10.1016/j.bmc.2015.09.017. Epub 2015 Sep 9.


Crystal Structures of a Hyperthermophilic Archaeal Homoserine Dehydrogenase Suggest a Novel Cofactor Binding Mode for Oxidoreductases.

Hayashi J, Inoue S, Kim K, Yoneda K, Kawarabayasi Y, Ohshima T, Sakuraba H.

Sci Rep. 2015 Jul 8;5:11674. doi: 10.1038/srep11674.


Structural basis for a bispecific NADP+ and CoA binding site in an archaeal malonyl-coenzyme A reductase.

Demmer U, Warkentin E, Srivastava A, Kockelkorn D, Pötter M, Marx A, Fuchs G, Ermler U.

J Biol Chem. 2013 Mar 1;288(9):6363-70. doi: 10.1074/jbc.M112.421263. Epub 2013 Jan 16.


Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase.

Luniwal A, Wang L, Pavlovsky A, Erhardt PW, Viola RE.

Bioorg Med Chem. 2012 May 1;20(9):2950-6. doi: 10.1016/j.bmc.2012.03.013. Epub 2012 Mar 10.


The catalytic machinery of a key enzyme in amino Acid biosynthesis.

Viola RE, Faehnle CR, Blanco J, Moore RA, Liu X, Arachea BT, Pavlovsky AG.

J Amino Acids. 2011;2011:352538. doi: 10.4061/2011/352538. Epub 2010 Dec 22.


Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis.

Vyas R, Kumar V, Panjikar S, Karthikeyan S, Kishan KV, Tewari R, Weiss MS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Mar 1;64(Pt 3):167-70. doi: 10.1107/S1744309108002753. Epub 2008 Feb 23.


Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.

Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G.

J Bacteriol. 2006 Dec;188(24):8551-9. Epub 2006 Oct 13.


The initial step in the archaeal aspartate biosynthetic pathway catalyzed by a monofunctional aspartokinase.

Faehnle CR, Liu X, Pavlovsky A, Viola RE.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Oct 1;62(Pt 10):962-6. Epub 2006 Sep 30.

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