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Items: 1 to 20 of 25

1.

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

Gerber H, Wu F, Dimitrov M, Garcia Osuna GM, Fraering PC.

J Biol Chem. 2017 Mar 3;292(9):3751-3767. doi: 10.1074/jbc.M116.754101. Epub 2017 Jan 17.

PMID:
28096459
2.

Early pancreatic islet fate and maturation is controlled through RBP-Jκ.

Cras-Méneur C, Conlon M, Zhang Y, Pasca Di Magliano M, Bernal-Mizrachi E.

Sci Rep. 2016 May 31;6:26874. doi: 10.1038/srep26874.

3.

Age-specific localization of NMDA receptors on oligodendrocytes dictates axon function recovery after ischemia.

Baltan S.

Neuropharmacology. 2016 Nov;110(Pt B):626-632. doi: 10.1016/j.neuropharm.2015.09.015. Epub 2015 Sep 25. Review.

PMID:
26407763
4.

γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation.

D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM.

FASEB J. 2015 Aug;29(8):3335-41. doi: 10.1096/fj.15-271015. Epub 2015 Apr 22.

5.

Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex.

Watanabe H, Iqbal M, Zheng J, Wines-Samuelson M, Shen J.

J Neurosci. 2014 Nov 26;34(48):15912-22. doi: 10.1523/JNEUROSCI.3261-14.2014.

6.

Synaptic function of nicastrin in hippocampal neurons.

Lee SH, Sharma M, Südhof TC, Shen J.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8973-8. doi: 10.1073/pnas.1408554111. Epub 2014 Jun 2.

7.

Function and dysfunction of presenilin.

Shen J.

Neurodegener Dis. 2014;13(2-3):61-3. doi: 10.1159/000354971. Epub 2013 Oct 2. Review.

8.

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.

Gunawardena S, Yang G, Goldstein LS.

Hum Mol Genet. 2013 Oct 1;22(19):3828-43. doi: 10.1093/hmg/ddt237. Epub 2013 May 24.

9.

Brain development and aging: overlapping and unique patterns of change.

Tamnes CK, Walhovd KB, Dale AM, Østby Y, Grydeland H, Richardson G, Westlye LT, Roddey JC, Hagler DJ Jr, Due-Tønnessen P, Holland D, Fjell AM; Alzheimer's Disease Neuroimaging Initiative..

Neuroimage. 2013 Mar;68:63-74. doi: 10.1016/j.neuroimage.2012.11.039. Epub 2012 Dec 12.

10.

The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain.

Sun YY, Li L, Liu XH, Gu N, Dong HL, Xiong L.

Mol Brain. 2012 Jun 19;5:23. doi: 10.1186/1756-6606-5-23.

11.

Presenilins in synaptic function and disease.

Ho A, Shen J.

Trends Mol Med. 2011 Nov;17(11):617-24. doi: 10.1016/j.molmed.2011.06.002. Epub 2011 Jul 26. Review.

12.

Presenilin-1 regulates neural progenitor cell differentiation in the adult brain.

Gadadhar A, Marr R, Lazarov O.

J Neurosci. 2011 Feb 16;31(7):2615-23. doi: 10.1523/JNEUROSCI.4767-10.2011.

13.

Presenilin controls CBP levels in the adult Drosophila central nervous system.

Boyles RS, Lantz KM, Poertner S, Georges SJ, Andres AJ.

PLoS One. 2010 Dec 14;5(12):e14332. doi: 10.1371/journal.pone.0014332.

14.

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.

Zhang D, Zhang C, Ho A, Kirkwood A, Südhof TC, Shen J.

J Neurochem. 2010 Dec;115(5):1215-21. doi: 10.1111/j.1471-4159.2010.07011.x. Epub 2010 Oct 26.

15.

Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistribution.

Lu Q, Ding K, Frosch MP, Jones S, Wolfe M, Xia W, Lanford GW.

J Alzheimers Dis. 2010;22(1):235-45. doi: 10.3233/JAD-2010-100585.

16.

Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.

Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ 3rd, Shen J.

PLoS One. 2010 Apr 15;5(4):e10195. doi: 10.1371/journal.pone.0010195.

17.

Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases.

Shen J.

Neurodegener Dis. 2010;7(1-3):80-3. doi: 10.1159/000285511. Epub 2010 Feb 18.

18.

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.

Cras-Méneur C, Li L, Kopan R, Permutt MA.

Genes Dev. 2009 Sep 1;23(17):2088-101. doi: 10.1101/gad.1800209.

19.

Indirect regulation of presenilins in CREB-mediated transcription.

Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ 3rd, Shen J.

J Biol Chem. 2009 May 15;284(20):13705-13. doi: 10.1074/jbc.M809168200. Epub 2009 Mar 16.

20.

Aging of signal transduction pathways, and pathology.

Carlson ME, Silva HS, Conboy IM.

Exp Cell Res. 2008 Jun 10;314(9):1951-61. doi: 10.1016/j.yexcr.2008.03.017. Epub 2008 Apr 7. Review.

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