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Items: 1 to 20 of 75

1.

USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7.

Kit Leng Lui S, Iyengar PV, Jaynes P, Isa ZFBA, Pang B, Tan TZ, Eichhorn PJA.

EMBO Rep. 2017 May;18(5):797-808. doi: 10.15252/embr.201643270. Epub 2017 Apr 5.

2.

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

Malonis RJ, Fu W, Jelcic MJ, Thompson M, Canter BS, Tsikitis M, Esteva FJ, Sánchez I.

J Biol Chem. 2017 May 5;292(18):7435-7451. doi: 10.1074/jbc.M117.783662. Epub 2017 Mar 14.

PMID:
28292929
3.

Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases.

Keszei AF, Sicheri F.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1311-1316. doi: 10.1073/pnas.1611595114. Epub 2017 Jan 23.

4.

Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.

Attali I, Tobelaim WS, Persaud A, Motamedchaboki K, Simpson-Lavy KJ, Mashahreh B, Levin-Kravets O, Keren-Kaplan T, Pilzer I, Kupiec M, Wiener R, Wolf DA, Rotin D, Prag G.

EMBO J. 2017 Feb 15;36(4):425-440. doi: 10.15252/embj.201694314. Epub 2017 Jan 9.

PMID:
28069708
6.

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.

Elkouris M, Kontaki H, Stavropoulos A, Antonoglou A, Nikolaou KC, Samiotaki M, Szantai E, Saviolaki D, Brown PJ, Sideras P, Panayotou G, Talianidis I.

Cell Rep. 2016 Jun 21;15(12):2733-44. doi: 10.1016/j.celrep.2016.05.051. Epub 2016 Jun 9.

7.

Smurf1 regulation of DAB2IP controls cell proliferation and migration.

Li X, Dai X, Wan L, Inuzuka H, Sun L, North BJ.

Oncotarget. 2016 May 3;7(18):26057-69. doi: 10.18632/oncotarget.8424.

8.

The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner.

Chandhoke AS, Karve K, Dadakhujaev S, Netherton S, Deng L, Bonni S.

Cell Death Differ. 2016 May;23(5):876-88. doi: 10.1038/cdd.2015.152. Epub 2015 Dec 18.

9.

Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.

O'Connor HF, Lyon N, Leung JW, Agarwal P, Swaim CD, Miller KM, Huibregtse JM.

EMBO Rep. 2015 Dec;16(12):1699-712. doi: 10.15252/embr.201540620. Epub 2015 Oct 27.

10.

USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.

Iyengar PV, Jaynes P, Rodon L, Lama D, Law KP, Lim YP, Verma C, Seoane J, Eichhorn PJ.

Sci Rep. 2015 Oct 5;5:14733. doi: 10.1038/srep14733.

11.

Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.

Riling C, Kamadurai H, Kumar S, O'Leary CE, Wu KP, Manion EE, Ying M, Schulman BA, Oliver PM.

J Biol Chem. 2015 Sep 25;290(39):23875-87. doi: 10.1074/jbc.M115.649269. Epub 2015 Aug 5.

12.

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases.

Mund T, Lewis MJ, Maslen S, Pelham HR.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41. doi: 10.1073/pnas.1412152111. Epub 2014 Nov 10.

13.
14.

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.

Herhaus L, Sapkota GP.

Cell Signal. 2014 Oct;26(10):2186-92. doi: 10.1016/j.cellsig.2014.06.012. Epub 2014 Jul 5. Review.

15.

Degradation of AIMP1/p43 induced by hepatitis C virus E2 leads to upregulation of TGF-β signaling and increase in surface expression of gp96.

Kim MS, Kim S, Myung H.

PLoS One. 2014 May 9;9(5):e96302. doi: 10.1371/journal.pone.0096302. eCollection 2014.

16.

KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.

Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, Lawrence TS, Nyati MK, Ray D.

Neoplasia. 2014 Feb;16(2):115-28. doi: 10.1593/neo.14184.

17.

Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring.

Finnson KW, McLean S, Di Guglielmo GM, Philip A.

Adv Wound Care (New Rochelle). 2013 Jun;2(5):195-214. Review.

18.

Perilous journey: a tour of the ubiquitin-proteasome system.

Kleiger G, Mayor T.

Trends Cell Biol. 2014 Jun;24(6):352-9. doi: 10.1016/j.tcb.2013.12.003. Epub 2014 Jan 20. Review.

19.

The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer.

Ronchi VP, Klein JM, Edwards DJ, Haas AL.

J Biol Chem. 2014 Jan 10;289(2):1033-48. doi: 10.1074/jbc.M113.517805. Epub 2013 Nov 22.

20.

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.

Kamadurai HB, Qiu Y, Deng A, Harrison JS, Macdonald C, Actis M, Rodrigues P, Miller DJ, Souphron J, Lewis SM, Kurinov I, Fujii N, Hammel M, Piper R, Kuhlman B, Schulman BA.

Elife. 2013 Aug 8;2:e00828. doi: 10.7554/eLife.00828.

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