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Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.

Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, Xu H, Hu M, Sun X, Sun S, Li J, Jiao R, Zuo P, Zheng L, Yue Z, Zhou Z.

Nat Commun. 2018 Jan 8;9(1):81. doi: 10.1038/s41467-017-02593-y.


Conformational Ensembles of α-Synuclein Derived Peptide with Different Osmolytes from Temperature Replica Exchange Sampling.

Jamal S, Kumari A, Singh A, Goyal S, Grover A.

Front Neurosci. 2017 Dec 7;11:684. doi: 10.3389/fnins.2017.00684. eCollection 2017.


SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation.

Rott R, Szargel R, Shani V, Hamza H, Savyon M, Abd Elghani F, Bandopadhyay R, Engelender S.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13176-13181. doi: 10.1073/pnas.1704351114. Epub 2017 Nov 27.


Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson's Disease.

Chen T, Tan J, Wan Z, Zou Y, Afewerky HK, Zhang Z, Zhang T.

Int J Mol Sci. 2017 Nov 23;18(12). pii: E2507. doi: 10.3390/ijms18122507.


Overexpression of miR‑185 inhibits autophagy and apoptosis of dopaminergic neurons by regulating the AMPK/mTOR signaling pathway in Parkinson's disease.

Wen Z, Zhang J, Tang P, Tu N, Wang K, Wu G.

Mol Med Rep. 2018 Jan;17(1):131-137. doi: 10.3892/mmr.2017.7897. Epub 2017 Oct 26.


Mitophagy in Parkinson's Disease: Pathogenic and Therapeutic Implications.

Gao F, Yang J, Wang D, Li C, Fu Y, Wang H, He W, Zhang J.

Front Neurol. 2017 Oct 4;8:527. doi: 10.3389/fneur.2017.00527. eCollection 2017. Review.


CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.

Kim H, Ham S, Jo M, Lee GH, Lee YS, Shin JH, Lee Y.

Int J Mol Sci. 2017 Oct 3;18(10). pii: E2093. doi: 10.3390/ijms18102093.


CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1.

Yoon KW, Yang HS, Kim YM, Kim Y, Kang S, Sun W, Naik UP, Parise LV, Choi EJ.

Sci Rep. 2017 Sep 22;7(1):12178. doi: 10.1038/s41598-017-12379-3.


The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.

Park HJ, Ryu D, Parmar M, Giasson BI, McFarland NR.

PLoS One. 2017 Sep 6;12(9):e0184262. doi: 10.1371/journal.pone.0184262. eCollection 2017.


Mitochondrial superclusters influence age of onset of Parkinson's disease in a gender specific manner in the Cypriot population: A case-control study.

Georgiou A, Demetriou CA, Heraclides A, Christou YP, Leonidou E, Loukaides P, Yiasoumi E, Panagiotou D, Manoli P, Thomson P, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E.

PLoS One. 2017 Sep 6;12(9):e0183444. doi: 10.1371/journal.pone.0183444. eCollection 2017.


Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation.

Sheng XJ, Tu HJ, Chien WL, Kang KH, Lu DH, Liou HH, Lee MJ, Fu WM.

PLoS One. 2017 Aug 14;12(8):e0183076. doi: 10.1371/journal.pone.0183076. eCollection 2017.


Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease.

Patel D, Witt SN.

Oxid Med Cell Longev. 2017;2017:4829180. doi: 10.1155/2017/4829180. Epub 2017 Jul 12. Review.


Mitochondrial Effects of PGC-1alpha Silencing in MPP+ Treated Human SH-SY5Y Neuroblastoma Cells.

Ye Q, Chen C, Si E, Cai Y, Wang J, Huang W, Li D, Wang Y, Chen X.

Front Mol Neurosci. 2017 May 29;10:164. doi: 10.3389/fnmol.2017.00164. eCollection 2017.


Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection.

Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH.

Oncotarget. 2017 Jul 25;8(30):48603-48618. doi: 10.18632/oncotarget.18122.


The potential role of neuroinflammation and transcription factors in Parkinson disease.

Tiwari PC, Pal R.

Dialogues Clin Neurosci. 2017 Mar;19(1):71-80. Review.


The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein.

Ruzafa D, Hernandez-Gomez YS, Bisello G, Broersen K, Morel B, Conejero-Lara F.

PLoS One. 2017 May 31;12(5):e0178576. doi: 10.1371/journal.pone.0178576. eCollection 2017.


Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.

Han KA, Yoo L, Sung JY, Chung SA, Um JW, Kim H, Seol W, Chung KC.

Front Cell Neurosci. 2017 May 11;11:125. doi: 10.3389/fncel.2017.00125. eCollection 2017.


Dicer and microRNAs protect adult dopamine neurons.

Chmielarz P, Konovalova J, Najam SS, Alter H, Piepponen TP, Erfle H, Sonntag KC, Schütz G, Vinnikov IA, Domanskyi A.

Cell Death Dis. 2017 May 25;8(5):e2813. doi: 10.1038/cddis.2017.214.


LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson's Disease.

Bouhouche A, Tibar H, Ben El Haj R, El Bayad K, Razine R, Tazrout S, Skalli A, Bouslam N, Elouardi L, Benomar A, Yahyaoui M, Regragui W.

Parkinsons Dis. 2017;2017:2412486. doi: 10.1155/2017/2412486. Epub 2017 Mar 30.


Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes.

Scott L, Dawson VL, Dawson TM.

Exp Neurol. 2017 Dec;298(Pt B):191-201. doi: 10.1016/j.expneurol.2017.04.008. Epub 2017 Apr 23. Review.


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