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Items: 1 to 20 of 33


Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells.

Ackermann M, Kuhn A, Kunkiel J, Merkert S, Martin U, Moritz T, Lachmann N.

Transfus Med Hemother. 2017 Jun;44(3):135-142. doi: 10.1159/000477129. Epub 2017 May 16.


Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells.

Nematpour F, Mahboudi F, Vaziri B, Khalaj V, Ahmadi S, Ahmadi M, Ebadat S, Davami F.

BMC Biotechnol. 2017 Feb 22;17(1):18. doi: 10.1186/s12896-017-0330-0.


Cloning and Characterization of a Human Genomic Sequence that Alleviates Repeat-Induced Gene Silencing.

Fukuma M, Ganmyo Y, Miura O, Ohyama T, Shimizu N.

PLoS One. 2016 Apr 14;11(4):e0153338. doi: 10.1371/journal.pone.0153338. eCollection 2016.


A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells.

Kang SY, Kim YG, Kang S, Lee HW, Lee EG.

Biotechnol J. 2016 May;11(5):633-41. doi: 10.1002/biot.201500464. Epub 2016 Feb 11.


CMV promoter mutants with a reduced propensity to productivity loss in CHO cells.

Moritz B, Becker PB, Göpfert U.

Sci Rep. 2015 Nov 19;5:16952. doi: 10.1038/srep16952.


Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins.

Maksimenko O, Gasanov NB, Georgiev P.

Acta Naturae. 2015 Jul-Sep;7(3):15-26.


Lentiviral Vectors Mediate Long-Term and High Efficiency Transgene Expression in HEK 293T cells.

Mao Y, Yan R, Li A, Zhang Y, Li J, Du H, Chen B, Wei W, Zhang Y, Sumners C, Zheng H, Li H.

Int J Med Sci. 2015 May 15;12(5):407-15. doi: 10.7150/ijms.11270. eCollection 2015.


Clinical applications of gene therapy for primary immunodeficiencies.

Cicalese MP, Aiuti A.

Hum Gene Ther. 2015 Apr;26(4):210-9. doi: 10.1089/hum.2015.047. Review.


Chromatin function modifying elements in an industrial antibody production platform--comparison of UCOE, MAR, STAR and cHS4 elements.

Saunders F, Sweeney B, Antoniou MN, Stephens P, Cain K.

PLoS One. 2015 Apr 7;10(4):e0120096. doi: 10.1371/journal.pone.0120096. eCollection 2015.


A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.

Müller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M.

Nucleic Acids Res. 2015 Feb 18;43(3):1577-92. doi: 10.1093/nar/gkv019. Epub 2015 Jan 20.


In utero therapy for congenital disorders using amniotic fluid stem cells.

Ramachandra DL, Shaw SS, Shangaris P, Loukogeorgakis S, Guillot PV, Coppi PD, David AL.

Front Pharmacol. 2014 Dec 19;5:270. doi: 10.3389/fphar.2014.00270. eCollection 2014. Erratum in: Front Pharmacol. 2015;6:39.


Molecular-genetic imaging of cancer.

Minn I, Menezes ME, Sarkar S, Yarlagadda K, Das SK, Emdad L, Sarkar D, Fisher PB, Pomper MG.

Adv Cancer Res. 2014;124:131-69. doi: 10.1016/B978-0-12-411638-2.00004-5. Review.


Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector.

Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou MN, Chan JK.

PLoS One. 2014 Aug 12;9(8):e104805. doi: 10.1371/journal.pone.0104805. eCollection 2014.


Recent advances in mammalian protein production.

Bandaranayake AD, Almo SC.

FEBS Lett. 2014 Jan 21;588(2):253-60. doi: 10.1016/j.febslet.2013.11.035. Epub 2013 Dec 6. Review.


Epigenetic regulatory elements associate with specific histone modifications to prevent silencing of telomeric genes.

Majocchi S, Aritonovska E, Mermod N.

Nucleic Acids Res. 2014 Jan;42(1):193-204. doi: 10.1093/nar/gkt880. Epub 2013 Sep 25.


Genomic cis-acting Sequences Improve Expression and Establishment of a Nonviral Vector.

Hagedorn C, Antoniou MN, Lipps HJ.

Mol Ther Nucleic Acids. 2013 Sep 3;2:e118. doi: 10.1038/mtna.2013.47.


Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing.

Knight S, Zhang F, Mueller-Kuller U, Bokhoven M, Gupta A, Broughton T, Sha S, Antoniou MN, Brendel C, Grez M, Thrasher AJ, Collins M, Takeuchi Y.

J Virol. 2012 Sep;86(17):9088-95. doi: 10.1128/JVI.00485-12. Epub 2012 Jun 13.


The chromatin backdrop of DNA replication: lessons from genetics and genome-scale analyses.

Conner AL, Aladjem MI.

Biochim Biophys Acta. 2012 Jul;1819(7):794-801. doi: 10.1016/j.bbagrm.2012.01.017. Epub 2012 Feb 8. Review.


Foamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome.

Uchiyama T, Adriani M, Jagadeesh GJ, Paine A, Candotti F.

Mol Ther. 2012 Jun;20(6):1270-9. doi: 10.1038/mt.2011.282. Epub 2012 Jan 3.


Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastoma.

Yamaguchi Y, Du XY, Zhao L, Morser J, Leung LL.

J Biol Chem. 2011 Nov 11;286(45):39510-9. doi: 10.1074/jbc.M111.258921. Epub 2011 Sep 23.

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