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miR-502-mediated histone methyltransferase SET8 expression is associated with clear cell renal cell carcinoma risk.

Zhang S, Guo Z, Xu J, Wang J, Zhang J, Cui L, Zhang H, Liu Y, Bai Y.

Oncol Lett. 2017 Dec;14(6):7131-7138. doi: 10.3892/ol.2017.7115. Epub 2017 Oct 2.


Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis.

Temimi AHKA, Reddy YV, White PB, Guo H, Qian P, Mecinović J.

Sci Rep. 2017 Nov 23;7(1):16148. doi: 10.1038/s41598-017-16128-4.


Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.

Judge RA, Zhu H, Upadhyay AK, Bodelle PM, Hutchins CW, Torrent M, Marin VL, Yu W, Vedadi M, Li F, Brown PJ, Pappano WN, Sun C, Petros AM.

ACS Med Chem Lett. 2016 Oct 11;7(12):1102-1106. eCollection 2016 Dec 8.


Molecular dynamics analysis to evaluate docking pose prediction.

Sakano T, Mahamood MI, Yamashita T, Fujitani H.

Biophys Physicobiol. 2016 Jul 14;13:181-194. eCollection 2016.


Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

Butler KV, Ma A, Yu W, Li F, Tempel W, Babault N, Pittella-Silva F, Shao J, Wang J, Luo M, Vedadi M, Brown PJ, Arrowsmith CH, Jin J.

J Med Chem. 2016 Nov 10;59(21):9881-9889. Epub 2016 Nov 2.


Structural insights into conformational stability of both wild-type and mutant EZH2 receptor.

Aier I, Varadwaj PK, Raj U.

Sci Rep. 2016 Oct 7;6:34984. doi: 10.1038/srep34984.


The emerging role of lysine methyltransferase SETD8 in human diseases.

Milite C, Feoli A, Viviano M, Rescigno D, Cianciulli A, Balzano AL, Mai A, Castellano S, Sbardella G.

Clin Epigenetics. 2016 Sep 22;8:102. eCollection 2016. Review.


A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle.

Zheng N, Dai X, Wang Z, Wei W.

Cell Cycle. 2016 Nov 16;15(22):3042-3047. Epub 2016 Sep 20.


Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia.

Abeykoon AH, Noinaj N, Choi BE, Wise L, He Y, Chao CC, Wang G, Gucek M, Ching WM, Chock PB, Buchanan SK, Yang DC.

J Biol Chem. 2016 Sep 16;291(38):19962-74. doi: 10.1074/jbc.M116.723460. Epub 2016 Jul 29.


Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate.

Girish TS, McGinty RK, Tan S.

J Mol Biol. 2016 Apr 24;428(8):1531-43. doi: 10.1016/j.jmb.2016.02.025. Epub 2016 Mar 4.


Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time.

van Nuland R, Gozani O.

Mol Cell Proteomics. 2016 Mar;15(3):755-64. doi: 10.1074/mcp.R115.054742. Epub 2015 Nov 23. Review.


Investigation of the methylation of Numb by the SET8 protein lysine methyltransferase.

Weirich S, Kusevic D, Kudithipudi S, Jeltsch A.

Sci Rep. 2015 Sep 22;5:13813. doi: 10.1038/srep13813.


Evolving Catalytic Properties of the MLL Family SET Domain.

Zhang Y, Mittal A, Reid J, Reich S, Gamblin SJ, Wilson JR.

Structure. 2015 Oct 6;23(10):1921-33. doi: 10.1016/j.str.2015.07.018. Epub 2015 Aug 27.


Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.

Rogawski DS, Ndoj J, Cho HJ, Maillard I, Grembecka J, Cierpicki T.

Biochemistry. 2015 Sep 8;54(35):5401-13. doi: 10.1021/acs.biochem.5b00697. Epub 2015 Aug 25.


Structure and function of SET and MYND domain-containing proteins.

Spellmon N, Holcomb J, Trescott L, Sirinupong N, Yang Z.

Int J Mol Sci. 2015 Jan 8;16(1):1406-28. doi: 10.3390/ijms16011406. Review.


The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.

Clifton MK, Westman BJ, Thong SY, O'Connell MR, Webster MW, Shepherd NE, Quinlan KG, Crossley M, Blobel GA, Mackay JP.

PLoS One. 2014 Aug 27;9(8):e106011. doi: 10.1371/journal.pone.0106011. eCollection 2014.


Small-molecule inhibitors of SETD8 with cellular activity.

Blum G, Ibáñez G, Rao X, Shum D, Radu C, Djaballah H, Rice JC, Luo M.

ACS Chem Biol. 2014 Nov 21;9(11):2471-8. doi: 10.1021/cb500515r. Epub 2014 Sep 3.


Structural and functional coordination of DNA and histone methylation.

Cheng X.

Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8). pii: a018747. doi: 10.1101/cshperspect.a018747. Review.


Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.

Ma A, Yu W, Li F, Bleich RM, Herold JM, Butler KV, Norris JL, Korboukh V, Tripathy A, Janzen WP, Arrowsmith CH, Frye SV, Vedadi M, Brown PJ, Jin J.

J Med Chem. 2014 Aug 14;57(15):6822-33. doi: 10.1021/jm500871s. Epub 2014 Jul 25.


SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity.

Leinhart K, Brown M.

Genes (Basel). 2011 Feb 21;2(1):210-8. doi: 10.3390/genes2010210.

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