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Effect of single doses of IV palonosetron, up to 2.25 mg, on the QTc interval duration: a double-blind, randomized, parallel group study in healthy volunteers.

Morganroth J, Flaharty KK, Parisi S, Moresino C.

Support Care Cancer. 2016 Feb;24(2):621-7. doi: 10.1007/s00520-015-2822-6. Epub 2015 Jun 26.


Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis.

Tricco AC, Soobiah C, Blondal E, Veroniki AA, Khan PA, Vafaei A, Ivory J, Strifler L, Ashoor H, MacDonald H, Reynen E, Robson R, Ho J, Ng C, Antony J, Mrklas K, Hutton B, Hemmelgarn BR, Moher D, Straus SE.

BMC Med. 2015 Jun 18;13:142. doi: 10.1186/s12916-015-0379-3. Review.


Efficacy of prophylactic intravenous ondansetron on the prevention of hypotension during cesarean delivery: a dose-dependent study.

Wang M, Zhuo L, Wang Q, Shen MK, Yu YY, Yu JJ, Wang ZP.

Int J Clin Exp Med. 2014 Dec 15;7(12):5210-6. eCollection 2014 Dec 15.


Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.

Tracz K, Owczuk R.

Br J Clin Pharmacol. 2015 Apr;79(4):669-76. doi: 10.1111/bcp.12527.


Effects of combined netupitant and palonosetron (NEPA), a cancer supportive care antiemetic, on the ECG of healthy subjects: an ICH E14 thorough QT trial.

Spinelli T, Moresino C, Baumann S, Timmer W, Schultz A.

Springerplus. 2014 Jul 29;3:389. doi: 10.1186/2193-1801-3-389. eCollection 2014 Jul 29.


Effects of palonosetron on prolongation of corrected QT intervals may be less than reliable.

Lee J, In J.

Korean J Anesthesiol. 2014 Apr;66(4):327-8. doi: 10.4097/kjae.2014.66.4.327. No abstract available.


Torsade de pointes in liver transplantation recipient after induction of general anesthesia: a case report.

Chung EJ, Jeon YS, Kim HJ, Lee KH, Lee JW, Han KA, Jung SH.

Korean J Anesthesiol. 2014 Jan;66(1):80-4. doi: 10.4097/kjae.2014.66.1.80. Epub 2014 Jan 28.


Intravenous palonosetron increases the incidence of QTc prolongation during sevoflurane general anesthesia for laparotomy.

Min JJ, Yoo Y, Kim TK, Lee JM.

Korean J Anesthesiol. 2013 Nov;65(5):397-402. doi: 10.4097/kjae.2013.65.5.397. Epub 2013 Nov 29.


High dose droperidol and QT prolongation: analysis of continuous 12-lead recordings.

Calver L, Isbister GK.

Br J Clin Pharmacol. 2014 May;77(5):880-6. doi: 10.1111/bcp.12272.


Perioperative torsade de pointes: a systematic review of published case reports.

Johnston J, Pal S, Nagele P.

Anesth Analg. 2013 Sep;117(3):559-64. doi: 10.1213/ANE.0b013e318290c380. Epub 2013 Jun 6. Review.


Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management.

Fazio G, Vernuccio F, Grutta G, Re GL.

World J Cardiol. 2013 Apr 26;5(4):87-93. doi: 10.4330/wjc.v5.i4.87.


Case scenario: anesthesia-related cardiac arrest in a child with Timothy syndrome.

Nathan AT, Antzelevitch C, Montenegro LM, Vetter VL.

Anesthesiology. 2012 Nov;117(5):1117-26. doi: 10.1097/ALN.0b013e31826e73b1. Review. No abstract available.


Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia.

Nagele P, Pal S, Brown F, Blood J, Miller JP, Johnston J.

Anesthesiology. 2012 Aug;117(2):321-8.


Evaluation of Ondansetron-induced QT interval prolongation in the prophylaxis of postoperative emesis.

Gupta SD, Pal R, Sarkar A, Mukherjee S, Mitra K, Roy S, Sarbapalli D, Kundu KK, Zaman FA, Kar S.

J Nat Sci Biol Med. 2011 Jan;2(1):119-24. doi: 10.4103/0976-9668.82306.


Reappraisal of the role of dolasetron in prevention and treatment of nausea and vomiting associated with surgery or chemotherapy.

Roberts SM, Bezinover DS, Janicki PK.

Cancer Manag Res. 2012;4:67-73. doi: 10.2147/CMAR.S15545. Epub 2012 Feb 24. Erratum in: Cancer Manag Res. 2016;8:83.


QTc prolongation assessment in anticancer drug development: clinical and methodological issues.

Curigliano G, Spitaleri G, de Braud F, Cardinale D, Cipolla C, Civelli M, Colombo N, Colombo A, Locatelli M, Goldhirsch A.

Ecancermedicalscience. 2009;3:130. doi: 10.3332/ecancer.2009.130. Epub 2009 Jan 12.

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