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Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating.

Mukherjee S, Thomas NL, Williams AJ.

Sci Rep. 2016 Oct 5;6:34452. doi: 10.1038/srep34452.


Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.

Dhakshnamoorthy B, Rohaim A, Rui H, Blachowicz L, Roux B.

Nat Commun. 2016 Sep 28;7:12753. doi: 10.1038/ncomms12753.


Evidence for a KATP Channel in Rough Endoplasmic Reticulum (rerKATP Channel) of Rat Hepatocytes.

Salari S, Ghasemi M, Fahanik-Babaei J, Saghiri R, Sauve R, Eliassi A.

PLoS One. 2015 May 7;10(5):e0125798. doi: 10.1371/journal.pone.0125798. eCollection 2015.


Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.

Zhou Y, Lingle CJ.

J Gen Physiol. 2014 Nov;144(5):415-40. doi: 10.1085/jgp.201411259.


Structures of KcsA in complex with symmetrical quaternary ammonium compounds reveal a hydrophobic binding site.

Lenaeus MJ, Burdette D, Wagner T, Focia PJ, Gross A.

Biochemistry. 2014 Aug 19;53(32):5365-73. doi: 10.1021/bi500525s. Epub 2014 Aug 8.


Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block.

Dempsey CE, Wright D, Colenso CK, Sessions RB, Hancox JC.

J Chem Inf Model. 2014 Feb 24;54(2):601-12. doi: 10.1021/ci400707h. Epub 2014 Feb 6.


Tethered spectroscopic probes estimate dynamic distances with subnanometer resolution in voltage-dependent potassium channels.

Jarecki BW, Zheng S, Zhang L, Li X, Zhou X, Cui Q, Tang W, Chanda B.

Biophys J. 2013 Dec 17;105(12):2724-32. doi: 10.1016/j.bpj.2013.11.010.


Interaction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stability.

Gray NW, Zhorov BS, Moczydlowski EG.

Channels (Austin). 2013 May-Jun;7(3):182-93. doi: 10.4161/chan.24455. Epub 2013 Apr 1.


The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.

Posson DJ, McCoy JG, Nimigean CM.

Nat Struct Mol Biol. 2013 Feb;20(2):159-66. doi: 10.1038/nsmb.2473. Epub 2012 Dec 23.


Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations.

Goodchild SJ, Xu H, Es-Salah-Lamoureux Z, Ahern CA, Fedida D.

J Gen Physiol. 2012 Nov;140(5):495-511. doi: 10.1085/jgp.201210823. Epub 2012 Oct 15.


The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides.

Mason SA, Viero C, Euden J, Bannister M, West D, Chen SR, Williams AJ.

J Gen Physiol. 2012 Sep;140(3):325-39. doi: 10.1085/jgp.201210851.


Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hK(v)1.3 channels.

Nikouee A, Janbein M, Grissmer S.

Br J Pharmacol. 2012 Nov;167(6):1378-88. doi: 10.1111/j.1476-5381.2012.02092.x.


Tuning the tetraethylammonium sensitivity of potassium channel Kcv by subunit combination.

Tan Q, Ritzo B, Tian K, Gu LQ.

J Gen Physiol. 2012 Apr;139(4):295-304. doi: 10.1085/jgp.201110725.


Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteries.

Khurana S, Raina H, Pappas V, Raufman JP, Pallone TL.

PLoS One. 2012;7(2):e32006. doi: 10.1371/journal.pone.0032006. Epub 2012 Feb 16.


Structural correlates of selectivity and inactivation in potassium channels.

McCoy JG, Nimigean CM.

Biochim Biophys Acta. 2012 Feb;1818(2):272-85. doi: 10.1016/j.bbamem.2011.09.007. Epub 2011 Sep 16. Review.


On the structural basis of modal gating behavior in K(+) channels.

Chakrapani S, Cordero-Morales JF, Jogini V, Pan AC, Cortes DM, Roux B, Perozo E.

Nat Struct Mol Biol. 2011 Jan;18(1):67-74. doi: 10.1038/nsmb.1968. Epub 2010 Dec 26.


Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium.

Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO.

J Gen Physiol. 2010 Sep;136(3):273-82. doi: 10.1085/jgp.200910398.


Overlapping binding sites of structurally different antiarrhythmics flecainide and propafenone in the subunit interface of potassium channel Kv2.1.

Madeja M, Steffen W, Mesic I, Garic B, Zhorov BS.

J Biol Chem. 2010 Oct 29;285(44):33898-905. doi: 10.1074/jbc.M110.159897. Epub 2010 Aug 13.


Potassium channel block by a tripartite complex of two cationophilic ligands and a potassium ion.

Zimin PI, Garic B, Bodendiek SB, Mahieux C, Wulff H, Zhorov BS.

Mol Pharmacol. 2010 Oct;78(4):588-99. doi: 10.1124/mol.110.064014. Epub 2010 Jul 2.


Allosteric block of KCa2 channels by apamin.

Lamy C, Goodchild SJ, Weatherall KL, Jane DE, LiƩgeois JF, Seutin V, Marrion NV.

J Biol Chem. 2010 Aug 27;285(35):27067-77. doi: 10.1074/jbc.M110.110072. Epub 2010 Jun 18.

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