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Items: 1 to 20 of 23


Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity.

Zhang J, Lei Z, Huang Z, Zhang X, Zhou Y, Luo Z, Zeng W, Su J, Peng C, Chen X.

Oncotarget. 2016 Nov 29;7(48):79557-79571. doi: 10.18632/oncotarget.12836.


A Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis.

Dey P, Panga V, Raghunathan S.

PLoS One. 2016 Sep 14;11(9):e0161306. doi: 10.1371/journal.pone.0161306. eCollection 2016.


Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6.

Min Y, Wi SM, Kang JA, Yang T, Park CS, Park SG, Chung S, Shim JH, Chun E, Lee KY.

Cell Death Dis. 2016 Jul 28;7(7):e2313. doi: 10.1038/cddis.2016.226.


The plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functions.

Karrich JJ, Jachimowski LC, Uittenbogaart CH, Blom B.

J Immunol. 2014 Dec 15;193(12):5772-8. doi: 10.4049/jimmunol.1401541. Review.


TAK1 control of cell death.

Mihaly SR, Ninomiya-Tsuji J, Morioka S.

Cell Death Differ. 2014 Nov;21(11):1667-76. doi: 10.1038/cdd.2014.123. Epub 2014 Aug 22. Review.


HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.

Liu R, Lin Y, Jia R, Geng Y, Liang C, Tan J, Qiao W.

Retrovirology. 2014 Jun 9;11:45. doi: 10.1186/1742-4690-11-45.


Activated macrophage survival is coordinated by TAK1 binding proteins.

Mihaly SR, Morioka S, Ninomiya-Tsuji J, Takaesu G.

PLoS One. 2014 Apr 15;9(4):e94982. doi: 10.1371/journal.pone.0094982. eCollection 2014.


Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways.

Chen C, Meng Y, Wang L, Wang HX, Tian C, Pang GD, Li HH, Du J.

Immunology. 2014 Jun;142(2):307-19. doi: 10.1111/imm.12255.


Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal.

Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E, Lee KY.

Mol Endocrinol. 2013 Nov;27(11):1958-68. doi: 10.1210/me.2013-1240. Epub 2013 Sep 23.


It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.

Love IM, Grossman SR.

Genes Cancer. 2012 Mar;3(3-4):249-63. doi: 10.1177/1947601912455198.


Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.

Omori E, Inagaki M, Mishina Y, Matsumoto K, Ninomiya-Tsuji J.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3365-70. doi: 10.1073/pnas.1116188109. Epub 2012 Feb 13.


Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.

Hamidi A, von Bulow V, Hamidi R, Winssinger N, Barluenga S, Heldin CH, Landström M.

J Biol Chem. 2012 Jan 2;287(1):123-33. doi: 10.1074/jbc.M111.285122. Epub 2011 Nov 8.


The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity.

Ovsyannikova IG, Haralambieva IH, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA.

Hum Genet. 2011 Oct;130(4):547-61. doi: 10.1007/s00439-011-0977-x. Epub 2011 Mar 19.


Lysine 63-linked ubiquitination is important for arachidonic acid-induced cellular adhesion and migration.

Ray DM, Rogers BA, Sunman JA, Akiyama SK, Olden K, Roberts JD.

Biochem Cell Biol. 2010 Dec;88(6):947-56. doi: 10.1139/O10-148.


Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process.

Scholz R, Sidler CL, Thali RF, Winssinger N, Cheung PC, Neumann D.

J Biol Chem. 2010 Aug 13;285(33):25753-66. doi: 10.1074/jbc.M109.093468. Epub 2010 Jun 10.


TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling.

Inagaki M, Omori E, Kim JY, Komatsu Y, Scott G, Ray MK, Yamada G, Matsumoto K, Mishina Y, Ninomiya-Tsuji J.

J Biol Chem. 2008 Nov 28;283(48):33080-6. doi: 10.1074/jbc.M807574200. Epub 2008 Oct 1.


Generation of a conditional mutant allele for Tab1 in mouse.

Inagaki M, Komatsu Y, Scott G, Yamada G, Ray M, Ninomiya-Tsuji J, Mishina Y.

Genesis. 2008 Aug;46(8):431-9. doi: 10.1002/dvg.20418.


TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB.

Prickett TD, Ninomiya-Tsuji J, Broglie P, Muratore-Schroeder TL, Shabanowitz J, Hunt DF, Brautigan DL.

J Biol Chem. 2008 Jul 11;283(28):19245-54. doi: 10.1074/jbc.M800943200. Epub 2008 May 2.


Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors.

Macedo L, Pinhal-Enfield G, Alshits V, Elson G, Cronstein BN, Leibovich SJ.

Am J Pathol. 2007 Dec;171(6):1774-88. Epub 2007 Nov 1.

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