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Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets.

Sun N, Keep RF, Hua Y, Xi G.

Transl Stroke Res. 2016 Oct;7(5):420-38. doi: 10.1007/s12975-016-0477-3. Review.


Extracellular cues influencing oligodendrocyte differentiation and (re)myelination.

Wheeler NA, Fuss B.

Exp Neurol. 2016 Sep;283(Pt B):512-30. doi: 10.1016/j.expneurol.2016.03.019. Review.


Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential.

Aoki M, Aoki H, Ramanathan R, Hait NC, Takabe K.

Mediators Inflamm. 2016;2016:8606878. doi: 10.1155/2016/8606878. Review. Erratum in: Mediators Inflamm. 2016;2016:2856829.


The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.

O'Sullivan C, Schubart A, Mir AK, Dev KK.

J Neuroinflammation. 2016 Feb 8;13:31. doi: 10.1186/s12974-016-0494-x.


Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors.

Wiltshire R, Nelson V, Kho DT, Angel CE, O'Carroll SJ, Graham ES.

Sci Rep. 2016 Jan 27;6:19814. doi: 10.1038/srep19814.


The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis.

Hunter SF, Bowen JD, Reder AT.

CNS Drugs. 2016 Feb;30(2):135-47. doi: 10.1007/s40263-015-0297-0. Review.


Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology.

Chew LJ, DeBoy CA.

Neuropharmacology. 2016 Nov;110(Pt B):605-625. doi: 10.1016/j.neuropharm.2015.06.008. Review.


Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?

Romero-Guevara R, Cencetti F, Donati C, Bruni P.

Front Aging Neurosci. 2015 Apr 23;7:60. doi: 10.3389/fnagi.2015.00060. Review.


Lysophospholipid receptors in drug discovery.

Kihara Y, Mizuno H, Chun J.

Exp Cell Res. 2015 May 1;333(2):171-7. doi: 10.1016/j.yexcr.2014.11.020. Review.


Broad integration of expression maps and co-expression networks compassing novel gene functions in the brain.

Okamura-Oho Y, Shimokawa K, Nishimura M, Takemoto S, Sato A, Furuichi T, Yokota H.

Sci Rep. 2014 Nov 10;4:6969. doi: 10.1038/srep06969.


ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.

Yamamoto R, Okada Y, Hirose J, Koshika T, Kawato Y, Maeda M, Saito R, Hattori K, Harada H, Nagasaka Y, Morokata T.

PLoS One. 2014 Oct 27;9(10):e110819. doi: 10.1371/journal.pone.0110819.


The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination.

Slowik A, Schmidt T, Beyer C, Amor S, Clarner T, Kipp M.

Br J Pharmacol. 2015 Jan;172(1):80-92. doi: 10.1111/bph.12938.


Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures.

Pritchard AJ, Mir AK, Dev KK.

PLoS One. 2014 Jun 9;9(6):e99444. doi: 10.1371/journal.pone.0099444.


Influence of drugs on gap junctions in glioma cell lines and primary astrocytes in vitro.

Moinfar Z, Dambach H, Faustmann PM.

Front Physiol. 2014 May 16;5:186. doi: 10.3389/fphys.2014.00186. Review.


An update on the biology of sphingosine 1-phosphate receptors.

Blaho VA, Hla T.

J Lipid Res. 2014 Aug;55(8):1596-608. doi: 10.1194/jlr.R046300.


Sphingosine-1-phosphate receptor 2.

Adada M, Canals D, Hannun YA, Obeid LM.

FEBS J. 2013 Dec;280(24):6354-66. doi: 10.1111/febs.12446. Review.


Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy.

Groves A, Kihara Y, Chun J.

J Neurol Sci. 2013 May 15;328(1-2):9-18. doi: 10.1016/j.jns.2013.02.011. Review.


GPCRs in stem cell function.

Doze VA, Perez DM.

Prog Mol Biol Transl Sci. 2013;115:175-216. doi: 10.1016/B978-0-12-394587-7.00005-1. Review.


Lysophospholipids and their receptors in the central nervous system.

Choi JW, Chun J.

Biochim Biophys Acta. 2013 Jan;1831(1):20-32. doi: 10.1016/j.bbalip.2012.07.015. Review.


G-protein-coupled receptors in adult neurogenesis.

Doze VA, Perez DM.

Pharmacol Rev. 2012 Jul;64(3):645-75. doi: 10.1124/pr.111.004762. Review.

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