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Hurdles in Basic Science Translation.

Perry CJ, Lawrence AJ.

Front Pharmacol. 2017 Jul 18;8:478. doi: 10.3389/fphar.2017.00478. eCollection 2017.


Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand.

Dalton JAR, Pin JP, Giraldo J.

Sci Rep. 2017 Jul 10;7(1):4944. doi: 10.1038/s41598-017-05095-5.


Activation of the same mGluR5 receptors in the amygdala causes divergent effects on specific versus indiscriminate fear.

Rahman MM, Kedia S, Fernandes G, Chattarji S.

Elife. 2017 May 30;6. pii: e25665. doi: 10.7554/eLife.25665.


Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas.

Pereira MSL, Klamt F, Thomé CC, Worm PV, de Oliveira DL.

Oncotarget. 2017 Mar 28;8(13):22279-22298. doi: 10.18632/oncotarget.15299. Review.


Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models.

Johnson MP, Muhlhauser MA, Nisenbaum ES, Simmons RM, Forster BM, Knopp KL, Yang L, Morrow D, Li DL, Kennedy JD, Swanson S, Monn JA.

Br J Pharmacol. 2017 May;174(9):822-835. doi: 10.1111/bph.13740. Epub 2017 Mar 13.


Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens.

Lee KM, Coelho MA, McGregor HA, Solton NR, Cohen M, Szumlinski KK.

Front Cell Neurosci. 2016 Nov 18;10:265. eCollection 2016.


Actions of Steroids: New Neurotransmitters.

Rudolph LM, Cornil CA, Mittelman-Smith MA, Rainville JR, Remage-Healey L, Sinchak K, Micevych PE.

J Neurosci. 2016 Nov 9;36(45):11449-11458. Review.


Preclinical anaylses of [18F]cEFQ as a PET tracer for imaging metabotropic glutamate receptor type 1 (mGluR1).

Lee B, Kim YK, Lee JY, Kim YJ, Lee YS, Lee DS, Chung JK, Jeong JM.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2283-2293. doi: 10.1177/0271678X16663948. Epub 2016 Jan 1.


Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications.

Palazzo E, Marabese I, de Novellis V, Rossi F, Maione S.

Curr Neuropharmacol. 2016;14(5):504-13. Review.


The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related Disorders.

Peterlik D, Flor PJ, Uschold-Schmidt N.

Curr Neuropharmacol. 2016;14(5):514-39. Review.


Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).

Gogliotti RD, Blobaum AL, Morrison RM, Daniels JS, Salovich JM, Cheung YY, Rodriguez AL, Loch MT, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):2984-7. doi: 10.1016/j.bmcl.2016.05.029. Epub 2016 May 11.


Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression.

Miyata S, Taniguchi M, Koyama Y, Shimizu S, Tanaka T, Yasuno F, Yamamoto A, Iida H, Kudo T, Katayama T, Tohyama M.

Sci Rep. 2016 Mar 15;6:23084. doi: 10.1038/srep23084.


Systematic Review of Pharmacological Properties of the Oligodendrocyte Lineage.

Marinelli C, Bertalot T, Zusso M, Skaper SD, Giusti P.

Front Cell Neurosci. 2016 Feb 12;10:27. doi: 10.3389/fncel.2016.00027. eCollection 2016. Review.


Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ.

Chem Rev. 2016 Jun 8;116(11):6707-41. doi: 10.1021/acs.chemrev.5b00656. Epub 2016 Feb 16. Review.


A randomized, placebo-controlled trial of D-cycloserine for the enhancement of social skills training in autism spectrum disorders.

Minshawi NF, Wink LK, Shaffer R, Plawecki MH, Posey DJ, Liu H, Hurwitz S, McDougle CJ, Swiezy NB, Erickson CA.

Mol Autism. 2016 Jan 14;7:2. doi: 10.1186/s13229-015-0062-8. eCollection 2016.


mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats.

Ahnaou A, Lavreysen H, Tresadern G, Cid JM, Drinkenburg WH.

PLoS One. 2015 Dec 11;10(12):e0144017. doi: 10.1371/journal.pone.0144017. eCollection 2015.


Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity.

Nasca C, Zelli D, Bigio B, Piccinin S, Scaccianoce S, Nisticò R, McEwen BS.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14960-5. doi: 10.1073/pnas.1516016112. Epub 2015 Nov 16.


Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein-Coupled Receptors.

Zurawski Z, Rodriguez S, Hyde K, Alford S, Hamm HE.

Mol Pharmacol. 2016 Jan;89(1):75-83. doi: 10.1124/mol.115.101600. Epub 2015 Oct 30.


VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.

Nickols HH, Yuh JP, Gregory KJ, Morrison RD, Bates BS, Stauffer SR, Emmitte KA, Bubser M, Peng W, Nedelcovych MT, Thompson A, Lv X, Xiang Z, Daniels JS, Niswender CM, Lindsley CW, Jones CK, Conn PJ.

J Pharmacol Exp Ther. 2016 Jan;356(1):123-36. doi: 10.1124/jpet.115.226597. Epub 2015 Oct 26.


Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective.

Dalton JA, Lans I, Rovira X, Malhaire F, Gómez-Santacana X, Pittolo S, Gorostiza P, Llebaria A, Goudet C, Pin JP, Giraldo J.

Curr Neuropharmacol. 2016;14(5):441-54.

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