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Items: 20


Structure-Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase.

Manlove AH, McKibbin PL, Doyle EL, Majumdar C, Hamm ML, David SS.

ACS Chem Biol. 2017 Sep 15;12(9):2335-2344. doi: 10.1021/acschembio.7b00389. Epub 2017 Aug 8.


Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.

Banda DM, Nuñez NN, Burnside MA, Bradshaw KM, David SS.

Free Radic Biol Med. 2017 Jun;107:202-215. doi: 10.1016/j.freeradbiomed.2017.01.008. Epub 2017 Jan 10. Review.


Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer.

Ray D, Kidane D.

J Cancer. 2016 Jul 4;7(11):1421-30. doi: 10.7150/jca.15480. eCollection 2016. Review.


SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp.

Hwang BJ, Jin J, Gao Y, Shi G, Madabushi A, Yan A, Guan X, Zalzman M, Nakajima S, Lan L, Lu AL.

BMC Mol Biol. 2015 Jun 11;16:12. doi: 10.1186/s12867-015-0041-9.


Nucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damages.

Cannan WJ, Tsang BP, Wallace SS, Pederson DS.

J Biol Chem. 2014 Jul 18;289(29):19881-93. doi: 10.1074/jbc.M114.571588. Epub 2014 Jun 2.


A chemical and kinetic perspective on base excision repair of DNA.

Schermerhorn KM, Delaney S.

Acc Chem Res. 2014 Apr 15;47(4):1238-46. doi: 10.1021/ar400275a. Epub 2014 Mar 19.


Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast.

Jin J, Hwang BJ, Chang PW, Toth EA, Lu AL.

DNA Repair (Amst). 2014 Mar;15:1-10. doi: 10.1016/j.dnarep.2014.01.001. Epub 2014 Feb 1.


Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

Luncsford PJ, Manvilla BA, Patterson DN, Malik SS, Jin J, Hwang BJ, Gunther R, Kalvakolanu S, Lipinski LJ, Yuan W, Lu W, Drohat AC, Lu AL, Toth EA.

DNA Repair (Amst). 2013 Dec;12(12):1043-52. doi: 10.1016/j.dnarep.2013.09.007. Epub 2013 Oct 24.


Understanding the role of the Q338H MUTYH variant in oxidative damage repair.

Turco E, Ventura I, Minoprio A, Russo MT, Torreri P, Degan P, Molatore S, Ranzani GN, Bignami M, Mazzei F.

Nucleic Acids Res. 2013 Apr;41(7):4093-103. doi: 10.1093/nar/gkt130. Epub 2013 Mar 4.


Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.

Raetz AG, Xie Y, Kundu S, Brinkmeyer MK, Chang C, David SS.

Carcinogenesis. 2012 Nov;33(11):2301-9. doi: 10.1093/carcin/bgs270. Epub 2012 Aug 26.


MUTYH-associated polyposis (MAP), the syndrome implicating base excision repair in inherited predisposition to colorectal tumors.

Venesio T, Balsamo A, D'Agostino VG, Ranzani GN.

Front Oncol. 2012 Aug 2;2:83. doi: 10.3389/fonc.2012.00083. eCollection 2012.


Chemical and biological consequences of oxidatively damaged guanine in DNA.

Delaney S, Jarem DA, Volle CB, Yennie CJ.

Free Radic Res. 2012 Apr;46(4):420-41. doi: 10.3109/10715762.2011.653968. Epub 2012 Feb 22. Review.


Variant base excision repair proteins: contributors to genomic instability.

Nemec AA, Wallace SS, Sweasy JB.

Semin Cancer Biol. 2010 Oct;20(5):320-8. doi: 10.1016/j.semcancer.2010.10.010. Epub 2010 Oct 16. Review.


Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): a mismatch recognition.

Kundu S, Brinkmeyer MK, Eigenheer RA, David SS.

DNA Repair (Amst). 2010 Oct 5;9(10):1026-37. doi: 10.1016/j.dnarep.2010.07.002. Epub 2010 Aug 17.


Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer.

Kundu S, Brinkmeyer MK, Livingston AL, David SS.

DNA Repair (Amst). 2009 Dec 3;8(12):1400-10. doi: 10.1016/j.dnarep.2009.09.009.


MUTYH Associated Polyposis (MAP).

Poulsen ML, Bisgaard ML.

Curr Genomics. 2008 Sep;9(6):420-35. doi: 10.2174/138920208785699562.


Biological contexts for DNA charge transport chemistry.

Merino EJ, Boal AK, Barton JK.

Curr Opin Chem Biol. 2008 Apr;12(2):229-37. doi: 10.1016/j.cbpa.2008.01.046. Epub 2008 Mar 17. Review.


Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY.

Livingston AL, O'Shea VL, Kim T, Kool ET, David SS.

Nat Chem Biol. 2008 Jan;4(1):51-8. Epub 2007 Nov 18.


Base-excision repair of oxidative DNA damage.

David SS, O'Shea VL, Kundu S.

Nature. 2007 Jun 21;447(7147):941-50. Review.

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