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Items: 16


Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

Duffy S, Sykes ML, Jones AJ, Shelper TB, Simpson M, Lang R, Poulsen SA, Sleebs BE, Avery VM.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00379-17. doi: 10.1128/AAC.00379-17. Print 2017 Sep.


An open source pharma roadmap.

Balasegaram M, Kolb P, McKew J, Menon J, Olliaro P, Sablinski T, Thomas Z, Todd MH, Torreele E, Wilbanks J.

PLoS Med. 2017 Apr 18;14(4):e1002276. doi: 10.1371/journal.pmed.1002276. eCollection 2017 Apr.


Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.

Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler EA, Wittlin S, Todd MH.

ACS Cent Sci. 2016 Oct 26;2(10):687-701. Epub 2016 Sep 14.


A systematic review and critical assessment of incentive strategies for discovery and development of novel antibiotics.

Renwick MJ, Brogan DM, Mossialos E.

J Antibiot (Tokyo). 2016 Feb;69(2):73-88. doi: 10.1038/ja.2015.98. Epub 2015 Oct 14. Review.


Emerging and reemerging neglected tropical diseases: a review of key characteristics, risk factors, and the policy and innovation environment.

Mackey TK, Liang BA, Cuomo R, Hafen R, Brouwer KC, Lee DE.

Clin Microbiol Rev. 2014 Oct;27(4):949-79. doi: 10.1128/CMR.00045-14. Review.


ModBase, a database of annotated comparative protein structure models and associated resources.

Pieper U, Webb BM, Dong GQ, Schneidman-Duhovny D, Fan H, Kim SJ, Khuri N, Spill YG, Weinkam P, Hammel M, Tainer JA, Nilges M, Sali A.

Nucleic Acids Res. 2014 Jan;42(Database issue):D336-46. doi: 10.1093/nar/gkt1144. Epub 2013 Nov 23.


Open source drug discovery - a limited tutorial.

Robertson MN, Ylioja PM, Williamson AE, Woelfle M, Robins M, Badiola KA, Willis P, Olliaro P, Wells TN, Todd MH.

Parasitology. 2014 Jan;141(1):148-57. doi: 10.1017/S0031182013001121. Epub 2013 Aug 28. Review.


Open source drug discovery in practice: a case study.

Årdal C, Røttingen JA.

PLoS Negl Trop Dis. 2012;6(9):e1827. doi: 10.1371/journal.pntd.0001827. Epub 2012 Sep 20.


Threats from emerging and re-emerging neglected tropical diseases (NTDs).

Mackey TK, Liang BA.

Infect Ecol Epidemiol. 2012;2. doi: 10.3402/iee.v2i0.18667. Epub 2012 Aug 1.


First Universities Allied for Essential Medicines (UAEM) Neglected Diseases and Innovation Symposium.

Musselwhite LW, Maciag K, Lankowski A, Gretes MC, Wellems TE, Tavera G, Goulding RE, Guillen E.

Am J Trop Med Hyg. 2012 Jan;86(1):65-74. doi: 10.4269/ajtmh.2012.11-0608.


Common characteristics of open source software development and applicability for drug discovery: a systematic review.

Ardal C, Alstadsæter A, Røttingen JA.

Health Res Policy Syst. 2011 Sep 28;9:36. doi: 10.1186/1478-4505-9-36.


A kernel for open source drug discovery in tropical diseases.

Ortí L, Carbajo RJ, Pieper U, Eswar N, Maurer SM, Rai AK, Taylor G, Todd MH, Pineda-Lucena A, Sali A, Marti-Renom MA.

PLoS Negl Trop Dis. 2009;3(4):e418. doi: 10.1371/journal.pntd.0000418. Epub 2009 Apr 21.


A kernel for the Tropical Disease Initiative.

Ortí L, Carbajo RJ, Pieper U, Eswar N, Maurer SM, Rai AK, Taylor G, Todd MH, Pineda-Lucena A, Sali A, Marti-Renom MA.

Nat Biotechnol. 2009 Apr;27(4):320-1. doi: 10.1038/nbt0409-320. No abstract available.


MODBASE, a database of annotated comparative protein structure models and associated resources.

Pieper U, Eswar N, Webb BM, Eramian D, Kelly L, Barkan DT, Carter H, Mankoo P, Karchin R, Marti-Renom MA, Davis FP, Sali A.

Nucleic Acids Res. 2009 Jan;37(Database issue):D347-54. doi: 10.1093/nar/gkn791. Epub 2008 Oct 23.


Host pathogen protein interactions predicted by comparative modeling.

Davis FP, Barkan DT, Eswar N, McKerrow JH, Sali A.

Protein Sci. 2007 Dec;16(12):2585-96. Epub 2007 Oct 26.


The courage to change the rules: a proposal for an essential health R&D treaty.

Dentico N, Ford N.

PLoS Med. 2005 Feb;2(2):e14. Epub 2005 Feb 22. No abstract available.

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