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Items: 10


Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo.

Verone-Boyle AR, Shoemaker S, Attwood K, Morrison CD, Makowski AJ, Battaglia S, Hershberger PA.

Oncotarget. 2016 Jan 5;7(1):995-1013. doi: 10.18632/oncotarget.6493.


Inhibition of protein kinase CK2 reduces Cyp24a1 expression and enhances 1,25-dihydroxyvitamin D(3) antitumor activity in human prostate cancer cells.

Luo W, Yu WD, Ma Y, Chernov M, Trump DL, Johnson CS.

Cancer Res. 2013 Apr 1;73(7):2289-97. doi: 10.1158/0008-5472.CAN-12-4119. Epub 2013 Jan 28.


CYP24 inhibition preserves 1α,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells.

Zhang Q, Kanterewicz B, Buch S, Petkovich M, Parise R, Beumer J, Lin Y, Diergaarde B, Hershberger PA.

Mol Cell Endocrinol. 2012 May 15;355(1):153-61. doi: 10.1016/j.mce.2012.02.006. Epub 2012 Feb 22.


A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay.

Beumer JH, Parise RA, Kanterewicz B, Petkovich M, D'Argenio DZ, Hershberger PA.

Steroids. 2012 Apr;77(5):477-83. doi: 10.1016/j.steroids.2012.01.007. Epub 2012 Jan 20.


Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase.

Chiellini G, Rapposelli S, Zhu J, Massarelli I, Saraceno M, Bianucci AM, Plum LA, Clagett-Dame M, DeLuca HF.

Steroids. 2012 Feb;77(3):212-23. doi: 10.1016/j.steroids.2011.11.007. Epub 2011 Nov 25.


Vitamin D metabolism and action in the prostate: implications for health and disease.

Swami S, Krishnan AV, Feldman D.

Mol Cell Endocrinol. 2011 Dec 5;347(1-2):61-9. doi: 10.1016/j.mce.2011.05.010. Epub 2011 Jun 1. Review.


Vitamin D: considerations in the continued development as an agent for cancer prevention and therapy.

Trump DL, Deeb KK, Johnson CS.

Cancer J. 2010 Jan-Feb;16(1):1-9. doi: 10.1097/PPO.0b013e3181c51ee6. Review.


Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone.

Prosser DE, Kaufmann M, O'Leary B, Byford V, Jones G.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12673-8. Epub 2007 Jul 23.


Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.

Bruno RD, Njar VC.

Bioorg Med Chem. 2007 Aug 1;15(15):5047-60. Epub 2007 May 23. Review.


Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation.

Posner GH, Suh BC, Petersen KS, Dolan P, Agoston ES, Kensler TW, Koh JT, Peleg S.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):213-21. Epub 2007 Jan 10.

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