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Items: 1 to 20 of 33


Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J.

Sci Rep. 2017 Apr 20;7(1):887. doi: 10.1038/s41598-017-00800-w.


Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.

Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E.

J Biol Chem. 2017 Jun 9;292(23):9523-9539. doi: 10.1074/jbc.M116.771394. Epub 2017 Apr 13.


Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.

Xiong J, Zhou MF, Wang YD, Chen LP, Xu WF, Wang YD, Deng F, Liu SD.

Sci Rep. 2016 Sep 23;6:34079. doi: 10.1038/srep34079.


The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias.

Carrà G, Torti D, Crivellaro S, Panuzzo C, Taulli R, Cilloni D, Guerrasio A, Saglio G, Morotti A.

Oncotarget. 2016 Oct 4;7(40):66287-66298. doi: 10.18632/oncotarget.11507. Review.


Extent of pre-translational regulation for the control of nucleocytoplasmic protein localization.

Luce MJ, Akpawu AA, Tucunduva DC, Mason S, Scott MS.

BMC Genomics. 2016 Jun 24;17:472. doi: 10.1186/s12864-016-2854-4.


HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.

Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J 3rd, Fröhling S, Scholl C, Seufferlein T.

Cancer Res. 2014 Dec 1;74(23):7125-36. doi: 10.1158/0008-5472.CAN-14-1017. Epub 2014 Oct 8.


Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway.

Wang H, Zhu X, Zhu Y, Liu J, Hu X, Wang Y, Peng S, Chen Y, Chen R, Ding F, Liu R.

Biomed Res Int. 2014;2014:968027. doi: 10.1155/2014/968027. Epub 2014 Jul 21.


Protein kinase d as a potential chemotherapeutic target for colorectal cancer.

Wei N, Chu E, Wipf P, Schmitz JC.

Mol Cancer Ther. 2014 May;13(5):1130-41. doi: 10.1158/1535-7163.MCT-13-0880. Epub 2014 Mar 14.


IKK-dependent activation of NF-κB contributes to myeloid and lymphoid leukemogenesis by BCR-ABL1.

Hsieh MY, Van Etten RA.

Blood. 2014 Apr 10;123(15):2401-11. doi: 10.1182/blood-2014-01-547943. Epub 2014 Jan 24.


Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy.

Fuchs SY.

J Interferon Cytokine Res. 2013 Apr;33(4):211-25. doi: 10.1089/jir.2012.0117. Review.


Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro.

Bernhart E, Damm S, Wintersperger A, DeVaney T, Zimmer A, Raynham T, Ireson C, Sattler W.

Exp Cell Res. 2013 Aug 1;319(13):2037-48. doi: 10.1016/j.yexcr.2013.03.029. Epub 2013 Apr 4.


Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.

Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H.

J Cell Biol. 2012 Jun 25;197(7):983-96. doi: 10.1083/jcb.201201065.


Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells.

Young SH, Rozengurt N, Sinnett-Smith J, Rozengurt E.

Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. doi: 10.1152/ajpgi.00025.2012. Epub 2012 May 17.


Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

Moulick K, Ahn JH, Zong H, Rodina A, Cerchietti L, Gomes DaGama EM, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu LP, Zhao X, Zatorska D, Taldone T, Smith-Jones P, Alpaugh M, Gross SS, Pillarsetty N, Ku T, Lewis JS, Larson SM, Levine R, Erdjument-Bromage H, Guzman ML, Nimer SD, Melnick A, Neckers L, Chiosis G.

Nat Chem Biol. 2011 Sep 25;7(11):818-26. doi: 10.1038/nchembio.670.


Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor.

Zheng H, Qian J, Baker DP, Fuchs SY.

J Biol Chem. 2011 Oct 14;286(41):35733-41. doi: 10.1074/jbc.M111.263608. Epub 2011 Aug 24.


Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor.

Bhattacharya S, Zheng H, Tzimas C, Carroll M, Baker DP, Fuchs SY.

Blood. 2011 Oct 13;118(15):4179-87. doi: 10.1182/blood-2010-12-325373. Epub 2011 Aug 5.


Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.

Azoitei N, Kleger A, Schoo N, Thal DR, Brunner C, Pusapati GV, Filatova A, Genze F, Möller P, Acker T, Kuefer R, Van Lint J, Baust H, Adler G, Seufferlein T.

Neuro Oncol. 2011 Jul;13(7):710-24. doi: 10.1093/neuonc/nor084.


Protein kinase D signaling: multiple biological functions in health and disease.

Rozengurt E.

Physiology (Bethesda). 2011 Feb;26(1):23-33. doi: 10.1152/physiol.00037.2010. Review.


Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2.

Zheng H, Qian J, Varghese B, Baker DP, Fuchs S.

Mol Cell Biol. 2011 Feb;31(4):710-20. doi: 10.1128/MCB.01154-10. Epub 2010 Dec 20.


Protein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts.

Sinnett-Smith J, Rozengurt N, Kui R, Huang C, Rozengurt E.

J Biol Chem. 2011 Jan 7;286(1):511-20. doi: 10.1074/jbc.M110.167528. Epub 2010 Nov 4.

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