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Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break.

Qiu Z, Zhang Z, Roschke A, Varga T, Aplan PD.

Sci Rep. 2017 Feb 22;7:43156. doi: 10.1038/srep43156.


ATM participates in the regulation of viability and cell cycle via ellipticine in bladder cancer.

Tao S, Meng S, Zheng X, Xie L.

Mol Med Rep. 2017 Mar;15(3):1143-1148. doi: 10.3892/mmr.2017.6141. Epub 2017 Jan 24.


The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.

Zhang X, Trépanier V, Beaujois R, Viranaicken W, Drobetsky E, DesGroseillers L.

Nucleic Acids Res. 2016 May 5;44(8):3695-712. doi: 10.1093/nar/gkw057. Epub 2016 Feb 3.


A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability.

Li P, Ma X, Adams IR, Yuan P.

Cell Death Dis. 2015 Jan 8;6:e1588. doi: 10.1038/cddis.2014.551.


Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.

Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P.

Cancer Res. 2014 Dec 15;74(24):7534-45. doi: 10.1158/0008-5472.CAN-14-2650. Epub 2014 Oct 21.


The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance.

Beerman TA, Gawron LS, Shen B, Kennedy DR.

DNA Repair (Amst). 2014 Sep;21:165-70. doi: 10.1016/j.dnarep.2014.06.001. Epub 2014 Jun 28.


N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells.

Bodakuntla S, Libi AV, Sural S, Trivedi P, Lahiri M.

BMC Cancer. 2014 Apr 24;14:287. doi: 10.1186/1471-2407-14-287.


Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.

Guo J, Wu G, Bao J, Hao W, Lu J, Chen X.

PLoS One. 2014 Feb 4;9(2):e88140. doi: 10.1371/journal.pone.0088140. eCollection 2014.


Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.

Parikh RA, Appleman LJ, Bauman JE, Sankunny M, Lewis DW, Vlad A, Gollin SM.

Genes Chromosomes Cancer. 2014 Jan;53(1):25-37. doi: 10.1002/gcc.22115. Epub 2013 Oct 21.


Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct.

Stokes MP, Silva JC, Jia X, Lee KA, Polakiewicz RD, Comb MJ.

Int J Mol Sci. 2012 Dec 21;14(1):286-307. doi: 10.3390/ijms14010286.


DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis.

Darzynkiewicz Z, Zhao H, Halicka HD, Rybak P, Dobrucki J, Wlodkowic D.

Crit Rev Clin Lab Sci. 2012 Sep-Dec;49(5-6):199-217. doi: 10.3109/10408363.2012.738808. Epub 2012 Nov 9. Review.


Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.

Arango D, Parihar A, Villamena FA, Wang L, Freitas MA, Grotewold E, Doseff AI.

Biochem Pharmacol. 2012 Dec 15;84(12):1571-80. doi: 10.1016/j.bcp.2012.09.005. Epub 2012 Sep 14.


Targeting protective autophagy exacerbates UV-triggered apoptotic cell death.

Chen LH, Chu PM, Lee YJ, Tu PH, Chi CW, Lee HC, Chiou SH.

Int J Mol Sci. 2012;13(1):1209-24. doi: 10.3390/ijms13011209. Epub 2012 Jan 20.


XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase.

Li Z, Musich PR, Serrano MA, Dong Z, Zou Y.

PLoS One. 2011;6(12):e28326. doi: 10.1371/journal.pone.0028326. Epub 2011 Dec 12.


Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategies.

Poltz R, Franke R, Schweitzer K, Klamt S, Gilles ED, Naumann M.

Adv Appl Bioinform Chem. 2009;2:125-38. Epub 2009 Dec 3.


The role of XPC: implications in cancer and oxidative DNA damage.

Melis JP, Luijten M, Mullenders LH, van Steeg H.

Mutat Res. 2011 Nov-Dec;728(3):107-17. doi: 10.1016/j.mrrev.2011.07.001. Epub 2011 Jul 7.


Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry.

Darzynkiewicz Z, Traganos F, Zhao H, Halicka HD, Skommer J, Wlodkowic D.

Methods Cell Biol. 2011;103:115-47. doi: 10.1016/B978-0-12-385493-3.00006-1. Review.


The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.

Gewandter JS, Bambara RA, O'Reilly MA.

Cell Cycle. 2011 Aug 1;10(15):2561-7. Epub 2011 Aug 1.


Antisense oligodeoxynucleotides targeting ATM strengthen apoptosis of laryngeal squamous cell carcinoma grown in nude mice.

Feng J, Zou J, Li L, Zhao Y, Liu S.

J Exp Clin Cancer Res. 2011 Apr 17;30:43. doi: 10.1186/1756-9966-30-43.

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