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Items: 1 to 20 of 45


Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

Widen JC, Kempema AM, Villalta PW, Harki DA.

ACS Chem Biol. 2017 Jan 20;12(1):102-113. doi: 10.1021/acschembio.6b00751. Epub 2016 Nov 28.


Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway.

Yu Y, Yu Y, Liu M, Yu P, Liu G, Liu Y, Su Y, Jiang H, Chen R.

Springerplus. 2016 Feb 29;5:215. doi: 10.1186/s40064-016-1857-6. eCollection 2016.


Effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenteric microcirculation during early sepsis treatment.

Guarda IF, Correia CJ, Breithaupt-Faloppa AC, Ferreira SG, Moreno AC, Martinez MB, Rocha-e-Silva M, Sannomiya P.

Clinics (Sao Paulo). 2015 Jul;70(7):508-14. doi: 10.6061/clinics/2015(07)08. Epub 2015 Jul 1.


Ethyl pyruvate attenuates murine allergic rhinitis partly by decreasing high mobility group box 1 release.

Chen S, Wang Y, Gong G, Chen J, Niu Y, Kong W.

Exp Biol Med (Maywood). 2015 Nov;240(11):1490-9. doi: 10.1177/1535370214566563. Epub 2015 Feb 13.


Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.

Alexeev V, Lash E, Aguillard A, Corsini L, Bitterman A, Ward K, Dicker AP, Linnenbach A, Rodeck U.

Mol Cancer Ther. 2014 Dec;13(12):2968-77. doi: 10.1158/1535-7163.MCT-14-0354. Epub 2014 Nov 14.


Ethyl pyruvate inhibits HMGB1 phosphorylation and release by chelating calcium.

Shin JH, Kim ID, Kim SW, Lee HK, Jin Y, Park JH, Kim TK, Suh CK, Kwak J, Lee KH, Han PL, Lee JK.

Mol Med. 2015 Mar 13;20:649-57. doi: 10.2119/molmed.2014.00039.


Effects of ethyl pyruvate on cardiac function recovery and apoptosis reduction after global cold ischemia and reperfusion.

Guo J, Zhang J, Luo X, Luo W, Lin C, Zhang K, Ji Y.

Exp Ther Med. 2014 May;7(5):1197-1202. Epub 2014 Feb 24. Erratum in: Exp Ther Med. 2016 Feb;11(2):688.


Thrombin promotes fibronectin secretion by bone marrow mesenchymal stem cells via the protease-activated receptor mediated signalling pathways.

Chen J, Ma Y, Wang Z, Wang H, Wang L, Xiao F, Wang H, Tan J, Guo Z.

Stem Cell Res Ther. 2014 Mar 17;5(2):36. doi: 10.1186/scrt424.


Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor κB (NF-κB) pathway.

Du J, Huang Y, Yan H, Zhang Q, Zhao M, Zhu M, Liu J, Chen SX, Bu D, Tang C, Jin H.

J Biol Chem. 2014 Apr 4;289(14):9741-53. doi: 10.1074/jbc.M113.517995. Epub 2014 Feb 18.


Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue.

Nativel B, Marimoutou M, Thon-Hon VG, Gunasekaran MK, Andries J, Stanislas G, Planesse C, Da Silva CR, Césari M, Iwema T, Gasque P, Viranaicken W.

PLoS One. 2013 Sep 20;8(9):e76039. doi: 10.1371/journal.pone.0076039. eCollection 2013.


Multiple sclerosis: molecular mechanisms and therapeutic opportunities.

Miljković D, Spasojević I.

Antioxid Redox Signal. 2013 Dec 20;19(18):2286-334. doi: 10.1089/ars.2012.5068. Epub 2013 Apr 22. Review.


The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65.

Silva DS, Pereira LM, Moreira AR, Ferreira-da-Silva F, Brito RM, Faria TQ, Zornetta I, Montecucco C, Oliveira P, Azevedo JE, Pereira PJ, Macedo-Ribeiro S, do Vale A, dos Santos NM.

PLoS Pathog. 2013 Feb;9(2):e1003128. doi: 10.1371/journal.ppat.1003128. Epub 2013 Feb 28.


Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.

Gupta D, Du Y, Piluek J, Jakub AM, Buela KA, Abbott A, Schuman JS, SundarRaj N.

Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6589-99.


HMGB1 in renal ischemic injury.

Rabadi MM, Ghaly T, Goligorksy MS, Ratliff BB.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F873-85. doi: 10.1152/ajprenal.00092.2012. Epub 2012 Jul 3.


Ethyl pyruvate promotes spinal cord repair by ameliorating the glial microenvironment.

Yuan Y, Su Z, Pu Y, Liu X, Chen J, Zhu F, Zhu Y, Zhang H, He C.

Br J Pharmacol. 2012 May;166(2):749-63. doi: 10.1111/j.1476-5381.2011.01804.x.


Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats.

Kalariya NM, Reddy AB, Ansari NH, VanKuijk FJ, Ramana KV.

Invest Ophthalmol Vis Sci. 2011 Jul 11;52(8):5144-52. doi: 10.1167/iovs.10-7047.


Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion.

Crawford RS, Albadawi H, Atkins MD, Jones JJ, Conrad MF, Austen WG Jr, Fink MP, Watkins MT.

J Trauma. 2011 Jan;70(1):103-10; discussion 110. doi: 10.1097/TA.0b013e3182031ccb.


Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes.

Frost RA, Pereyra E, Lang CH.

Endocrinology. 2011 Jan;152(1):151-63. doi: 10.1210/en.2010-0248. Epub 2010 Nov 24.

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