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Items: 1 to 20 of 47

1.

Epigenetic regulation of starvation-induced autophagy in Drosophila by histone methyltransferase G9a.

An PNT, Shimaji K, Tanaka R, Yoshida H, Kimura H, Fukusaki E, Yamaguchi M.

Sci Rep. 2017 Aug 4;7(1):7343. doi: 10.1038/s41598-017-07566-1.

2.

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.

Xiong Y, Li F, Babault N, Wu H, Dong A, Zeng H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin J.

Bioorg Med Chem. 2017 Aug 15;25(16):4414-4423. doi: 10.1016/j.bmc.2017.06.021. Epub 2017 Jun 19.

PMID:
28662962
3.

Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity.

Berry S, Dean C, Howard M.

Cell Syst. 2017 Apr 26;4(4):445-457.e8. doi: 10.1016/j.cels.2017.02.013. Epub 2017 Mar 22.

4.

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

Xiong Y, Li F, Babault N, Dong A, Zeng H, Wu H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin J.

J Med Chem. 2017 Mar 9;60(5):1876-1891. doi: 10.1021/acs.jmedchem.6b01645. Epub 2017 Feb 14.

PMID:
28135087
5.

Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.

Linscott JA, Kapilashrami K, Wang Z, Senevirathne C, Bothwell IR, Blum G, Luo M.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8369-E8378. doi: 10.1073/pnas.1609032114. Epub 2016 Dec 9.

6.

Lack of global epigenetic methylation defects in CBS deficient mice.

Lee HO, Wang L, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD.

J Inherit Metab Dis. 2017 Jan;40(1):113-120. doi: 10.1007/s10545-016-9958-5. Epub 2016 Jul 21.

PMID:
27444757
7.

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites.

Chen PB, Ding S, Zanghì G, Soulard V, DiMaggio PA, Fuchter MJ, Mecheri S, Mazier D, Scherf A, Malmquist NA.

Sci Rep. 2016 Feb 23;6:21802. doi: 10.1038/srep21802.

9.

A continuous kinetic assay for protein and DNA methyltransferase enzymatic activities.

Duchin S, Vershinin Z, Levy D, Aharoni A.

Epigenetics Chromatin. 2015 Dec 15;8:56. doi: 10.1186/s13072-015-0048-y. eCollection 2015.

10.

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability.

Liu M, Barnes VL, Pile LA.

G3 (Bethesda). 2015 Nov 6;6(1):121-32. doi: 10.1534/g3.115.024273.

11.

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.

Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gómez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla SN, Locasale JW.

Cell Metab. 2015 Nov 3;22(5):861-73. doi: 10.1016/j.cmet.2015.08.024. Epub 2015 Sep 24.

12.

Methylation of histone H3 lysine 9 occurs during translation.

Rivera C, Saavedra F, Alvarez F, Díaz-Celis C, Ugalde V, Li J, Forné I, Gurard-Levin ZA, Almouzni G, Imhof A, Loyola A.

Nucleic Acids Res. 2015 Oct 30;43(19):9097-106. doi: 10.1093/nar/gkv929. Epub 2015 Sep 24.

13.

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

Stulemeijer IJ, De Vos D, van Harten K, Joshi OK, Blomberg O, van Welsem T, Terweij M, Vlaming H, de Graaf EL, Altelaar AF, Bakker BM, van Leeuwen F.

Sci Rep. 2015 May 12;5:9824. doi: 10.1038/srep09824.

14.

A direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferases.

Richardson SL, Hanjra P, Zhang G, Mackie BD, Peterson DL, Huang R.

Anal Biochem. 2015 Jun 1;478:59-64. doi: 10.1016/j.ab.2015.03.007. Epub 2015 Mar 14.

15.

Metabolic regulation of histone post-translational modifications.

Fan J, Krautkramer KA, Feldman JL, Denu JM.

ACS Chem Biol. 2015 Jan 16;10(1):95-108. doi: 10.1021/cb500846u. Review.

16.

Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2.

Mozzetta C, Pontis J, Ait-Si-Ali S.

Antioxid Redox Signal. 2015 Jun 1;22(16):1365-81. doi: 10.1089/ars.2014.6116. Epub 2014 Dec 19. Review.

17.

Large-scale global identification of protein lysine methylation in vivo.

Cao XJ, Arnaudo AM, Garcia BA.

Epigenetics. 2013 May;8(5):477-85. doi: 10.4161/epi.24547. Epub 2013 Apr 17.

18.

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions.

Seidel SA, Dijkman PM, Lea WA, van den Bogaart G, Jerabek-Willemsen M, Lazic A, Joseph JS, Srinivasan P, Baaske P, Simeonov A, Katritch I, Melo FA, Ladbury JE, Schreiber G, Watts A, Braun D, Duhr S.

Methods. 2013 Mar;59(3):301-15. doi: 10.1016/j.ymeth.2012.12.005. Epub 2012 Dec 24. Review.

19.

G9a, a multipotent regulator of gene expression.

Shankar SR, Bahirvani AG, Rao VK, Bharathy N, Ow JR, Taneja R.

Epigenetics. 2013 Jan;8(1):16-22. doi: 10.4161/epi.23331. Epub 2012 Dec 20. Review.

20.

Epigenetic regulation of CXCR4 expression by the ocular microenvironment.

Li H, Niederkorn JY, Sadegh L, Mellon J, Chen PW.

Invest Ophthalmol Vis Sci. 2013 Jan 9;54(1):234-43. doi: 10.1167/iovs.12-10643.

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