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Items: 1 to 20 of 33

1.

Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks.

Zhang H, Hua Y, Li R, Kong D.

J Biol Chem. 2016 Nov 25;291(48):24961-24973. Epub 2016 Oct 11.

PMID:
27729451
2.

Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.

Colosio A, Frattini C, Pellicanò G, Villa-Hernández S, Bermejo R.

Nucleic Acids Res. 2016 Dec 15;44(22):10676-10690. Epub 2016 Sep 26.

3.

A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.

Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, Wu Q, Liu C, Karanja KK, Popuri V, Shan SO, Schlacher K, Zheng L, Campbell JL, Shen B.

EBioMedicine. 2016 Apr;6:73-86. doi: 10.1016/j.ebiom.2016.02.043. Epub 2016 Mar 10.

4.

Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.

Zhou C, Pourmal S, Pavletich NP.

Elife. 2015 Nov 2;4. pii: e09832. doi: 10.7554/eLife.09832.

5.

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination.

Cejka P.

J Biol Chem. 2015 Sep 18;290(38):22931-8. doi: 10.1074/jbc.R115.675942. Epub 2015 Jul 31. Review.

6.

The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication.

Levikova M, Cejka P.

Nucleic Acids Res. 2015 Sep 18;43(16):7888-97. doi: 10.1093/nar/gkv710. Epub 2015 Jul 14.

7.

Yet another job for Dna2: Checkpoint activation.

Wanrooij PH, Burgers PM.

DNA Repair (Amst). 2015 Aug;32:17-23. doi: 10.1016/j.dnarep.2015.04.009. Epub 2015 May 1. Review.

8.

Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity.

Levikova M, Klaue D, Seidel R, Cejka P.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):E1992-2001. doi: 10.1073/pnas.1300390110. Epub 2013 May 13.

9.

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.

Lin W, Sampathi S, Dai H, Liu C, Zhou M, Hu J, Huang Q, Campbell J, Shin-Ya K, Zheng L, Chai W, Shen B.

EMBO J. 2013 May 15;32(10):1425-39. doi: 10.1038/emboj.2013.88. Epub 2013 Apr 19.

10.

Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels.

Szczesny RJ, Hejnowicz MS, Steczkiewicz K, Muszewska A, Borowski LS, Ginalski K, Dziembowski A.

Nucleic Acids Res. 2013 Mar 1;41(5):3144-61. doi: 10.1093/nar/gkt029. Epub 2013 Jan 28.

11.

Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domain.

Pokharel S, Campbell JL.

Nucleic Acids Res. 2012 Sep;40(16):7821-30. doi: 10.1093/nar/gks534. Epub 2012 Jun 7.

12.

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.

Gloor JW, Balakrishnan L, Campbell JL, Bambara RA.

Nucleic Acids Res. 2012 Aug;40(14):6774-86. doi: 10.1093/nar/gks388. Epub 2012 May 7.

13.

Mammalian ChlR1 has a role in heterochromatin organization.

Inoue A, Hyle J, Lechner MS, Lahti JM.

Exp Cell Res. 2011 Oct 15;317(17):2522-35. doi: 10.1016/j.yexcr.2011.08.006. Epub 2011 Aug 11.

14.

Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.

Fortini BK, Pokharel S, Polaczek P, Balakrishnan L, Bambara RA, Campbell JL.

J Biol Chem. 2011 Jul 8;286(27):23763-70. doi: 10.1074/jbc.M111.243071. Epub 2011 May 13.

15.

Telomere replication: poised but puzzling.

Sampathi S, Chai W.

J Cell Mol Med. 2011 Jan;15(1):3-13. doi: 10.1111/j.1582-4934.2010.01220.x. Review.

16.

An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase.

Pike JE, Henry RA, Burgers PM, Campbell JL, Bambara RA.

J Biol Chem. 2010 Dec 31;285(53):41712-23. doi: 10.1074/jbc.M110.146894. Epub 2010 Oct 19.

17.

Dna2 exhibits a unique strand end-dependent helicase function.

Balakrishnan L, Polaczek P, Pokharel S, Campbell JL, Bambara RA.

J Biol Chem. 2010 Dec 10;285(50):38861-8. doi: 10.1074/jbc.M110.165191. Epub 2010 Oct 6.

18.

G-quadruplex nucleic acids and human disease.

Wu Y, Brosh RM Jr.

FEBS J. 2010 Sep;277(17):3470-88. doi: 10.1111/j.1742-4658.2010.07760.x. Epub 2010 Jul 29. Review.

19.

FEN1 ensures telomere stability by facilitating replication fork re-initiation.

Saharia A, Teasley DC, Duxin JP, Dao B, Chiappinelli KB, Stewart SA.

J Biol Chem. 2010 Aug 27;285(35):27057-66. doi: 10.1074/jbc.M110.112276. Epub 2010 Jun 15.

20.

Replication protein A: directing traffic at the intersection of replication and repair.

Oakley GG, Patrick SM.

Front Biosci (Landmark Ed). 2010 Jun 1;15:883-900. Review.

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