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The human decapping scavenger enzyme DcpS modulates microRNA turnover.

Meziane O, Piquet S, Bossé GD, Gagné D, Paquet E, Robert C, Tones MA, Simard MJ.

Sci Rep. 2015 Nov 20;5:16688. doi: 10.1038/srep16688.


Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.

Taverniti V, Séraphin B.

Nucleic Acids Res. 2015 Jan;43(1):482-92. doi: 10.1093/nar/gku1251. Epub 2014 Nov 28.


Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.

Kowalska J, Wypijewska del Nogal A, Darzynkiewicz ZM, Buck J, Nicola C, Kuhn AN, Lukaszewicz M, Zuberek J, Strenkowska M, Ziemniak M, Maciejczyk M, Bojarska E, Rhoads RE, Darzynkiewicz E, Sahin U, Jemielity J.

Nucleic Acids Res. 2014;42(16):10245-64. doi: 10.1093/nar/gku757. Epub 2014 Aug 22.


The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.

Bossé GD, Rüegger S, Ow MC, Vasquez-Rifo A, Rondeau EL, Ambros VR, Grosshans H, Simard MJ.

Mol Cell. 2013 Apr 25;50(2):281-7. doi: 10.1016/j.molcel.2013.02.023. Epub 2013 Mar 28.


Identification of Drosophila and human 7-methyl GMP-specific nucleotidases.

Buschmann J, Moritz B, Jeske M, Lilie H, Schierhorn A, Wahle E.

J Biol Chem. 2013 Jan 25;288(4):2441-51. doi: 10.1074/jbc.M112.426700. Epub 2012 Dec 5.


7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.

Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E.

Biochemistry. 2012 Oct 9;51(40):8003-13. doi: 10.1021/bi300781g. Epub 2012 Sep 25.


Synthesis of N²-modified 7-methylguanosine 5'-monophosphates as nematode translation inhibitors.

Piecyk K, Davis RE, Jankowska-Anyszka M.

Bioorg Med Chem. 2012 Aug 1;20(15):4781-9. doi: 10.1016/j.bmc.2012.05.078. Epub 2012 Jun 10.


Synthesis of ¹³C- and ¹⁴C-labeled dinucleotide mRNA cap analogues for structural and biochemical studies.

Piecyk K, Davis RE, Jankowska-Anyszka M.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4391-5. doi: 10.1016/j.bmcl.2012.04.120. Epub 2012 May 4.


Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins.

Szczepaniak SA, Zuberek J, Darzynkiewicz E, Kufel J, Jemielity J.

RNA. 2012 Jul;18(7):1421-32. doi: 10.1261/rna.032078.111. Epub 2012 May 15.


Nucleic acid transfection and transgenesis in parasitic nematodes.

Lok JB.

Parasitology. 2012 Apr;139(5):574-88. doi: 10.1017/S0031182011001387. Epub 2011 Aug 31. Review.


Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.

Wang J, Czech B, Crunk A, Wallace A, Mitreva M, Hannon GJ, Davis RE.

Genome Res. 2011 Sep;21(9):1462-77. doi: 10.1101/gr.121426.111. Epub 2011 Jun 17.


Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.

Strenkowska M, Kowalska J, Lukaszewicz M, Zuberek J, Su W, Rhoads RE, Darzynkiewicz E, Jemielity J.

New J Chem. 2010 Jan 1;34(5):993-1007.


Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.

Wypijewska A, Bojarska E, Stepinski J, Jankowska-Anyszka M, Jemielity J, Davis RE, Darzynkiewicz E.

FEBS J. 2010 Jul;277(14):3003-13. doi: 10.1111/j.1742-4658.2010.07709.x. Epub 2010 Jun 8.


Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins.

Banerjee H, Palenchar JB, Lukaszewicz M, Bojarska E, Stepinski J, Jemielity J, Guranowski A, Ng S, Wah DA, Darzynkiewicz E, Bellofatto V.

RNA. 2009 Aug;15(8):1554-64. doi: 10.1261/rna.1426609. Epub 2009 Jun 18.


Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.

Kowalska J, Lewdorowicz M, Zuberek J, Grudzien-Nogalska E, Bojarska E, Stepinski J, Rhoads RE, Darzynkiewicz E, Davis RE, Jemielity J.

RNA. 2008 Jun;14(6):1119-31. doi: 10.1261/rna.990208. Epub 2008 Apr 22.


DcpS scavenger decapping enzyme can modulate pre-mRNA splicing.

Shen V, Liu H, Liu SW, Jiao X, Kiledjian M.

RNA. 2008 Jun;14(6):1132-42. doi: 10.1261/rna.1008208. Epub 2008 Apr 21.


Transgenesis and neuronal ablation in parasitic nematodes: revolutionary new tools to dissect host-parasite interactions.

Lok JB, Artis D.

Parasite Immunol. 2008 Apr;30(4):203-14. doi: 10.1111/j.1365-3024.2008.01006.x. Review.


Strongyloides stercoralis: cell- and tissue-specific transgene expression and co-transformation with vector constructs incorporating a common multifunctional 3' UTR.

Junio AB, Li X, Massey HC Jr, Nolan TJ, Todd Lamitina S, Sundaram MV, Lok JB.

Exp Parasitol. 2008 Feb;118(2):253-65. Epub 2007 Sep 14.


In vivo translation and stability of trans-spliced mRNAs in nematode embryos.

Cheng G, Cohen L, Mikhli C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE.

Mol Biochem Parasitol. 2007 Jun;153(2):95-106. Epub 2007 Feb 21.


Scavenger decapping activity facilitates 5' to 3' mRNA decay.

Liu H, Kiledjian M.

Mol Cell Biol. 2005 Nov;25(22):9764-72.

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