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Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment.

Lopez-Cruzan M, Sharma R, Tiwari M, Karbach S, Holstein D, Martin CR, Lechleiter JD, Herman B.

Cell Death Discov. 2016 Feb 15;2. pii: 16005.


Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells.

Reyes-Zurita FJ, Rufino-Palomares EE, García-Salguero L, Peragón J, Medina PP, Parra A, Cascante M, Lupiáñez JA.

PLoS One. 2016 Jan 11;11(1):e0146178. doi: 10.1371/journal.pone.0146178.


Vibrio cholerae Porin OmpU Induces Caspase-independent Programmed Cell Death upon Translocation to the Host Cell Mitochondria.

Gupta S, Prasad GV, Mukhopadhaya A.

J Biol Chem. 2015 Dec 25;290(52):31051-68. doi: 10.1074/jbc.M115.670182.


Neuroprotective and Functional Improvement Effects of Methylene Blue in Global Cerebral Ischemia.

Lu Q, Tucker D, Dong Y, Zhao N, Zhang Q.

Mol Neurobiol. 2016 Oct;53(8):5344-55. doi: 10.1007/s12035-015-9455-0.


PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity.

Dabrowska A, Venero JL, Iwasawa R, Hankir MK, Rahman S, Boobis A, Hajji N.

Aging (Albany NY). 2015 Sep;7(9):629-47. Erratum in: Aging (Albany NY). 2015 Nov;7(11):1023. Aging (Albany NY). 2016 Apr;8(4):832.


Demyelination as a rational therapeutic target for ischemic or traumatic brain injury.

Shi H, Hu X, Leak RK, Shi Y, An C, Suenaga J, Chen J, Gao Y.

Exp Neurol. 2015 Oct;272:17-25. doi: 10.1016/j.expneurol.2015.03.017. Review.


The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria.

Marini ES, Giampietri C, Petrungaro S, Conti S, Filippini A, Scorrano L, Ziparo E.

Cell Death Differ. 2015 Jul;22(7):1131-43. doi: 10.1038/cdd.2014.197.


Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells.

Lim SW, Loh HS, Ting KN, Bradshaw TD, Zeenathul NA.

BMC Complement Altern Med. 2014 Dec 6;14:469. doi: 10.1186/1472-6882-14-469.


HIV-1 protease-induced apoptosis.

Rumlová M, Křížová I, Keprová A, Hadravová R, Doležal M, Strohalmová K, Pichová I, Hájek M, Ruml T.

Retrovirology. 2014 May 20;11:37. doi: 10.1186/1742-4690-11-37.


Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy.

Williams RT, Yu AL, Diccianni MB, Theodorakis EA, Batova A.

J Exp Clin Cancer Res. 2013 Aug 20;32:57. doi: 10.1186/1756-9966-32-57. Erratum in: J Exp Clin Cancer Res. 2014;33:95.


Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.

Jalmar O, François-Moutal L, García-Sáez AJ, Perry M, Granjon T, Gonzalvez F, Gottlieb E, Ayala-Sanmartin J, Klösgen B, Schwille P, Petit PX.

PLoS One. 2013;8(2):e55250. doi: 10.1371/journal.pone.0055250.


Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.

Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, Seshadri A, Sun L, Aldaz CM, Tang DG, Chandra D.

J Biol Chem. 2013 Jan 4;288(1):368-81. doi: 10.1074/jbc.M112.386102.


Mechanisms for ribotoxin-induced ribosomal RNA cleavage.

He K, Zhou HR, Pestka JJ.

Toxicol Appl Pharmacol. 2012 Nov 15;265(1):10-8. doi: 10.1016/j.taap.2012.09.017.


Differential effects of procaspase-3 activating compounds in the induction of cancer cell death.

West DC, Qin Y, Peterson QP, Thomas DL, Palchaudhuri R, Morrison KC, Lucas PW, Palmer AE, Fan TM, Hergenrother PJ.

Mol Pharm. 2012 May 7;9(5):1425-34. doi: 10.1021/mp200673n.


Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation.

Zhang H, Gogada R, Yadav N, Lella RK, Badeaux M, Ayres M, Gandhi V, Tang DG, Chandra D.

PLoS One. 2011 Jan 27;6(1):e16379. doi: 10.1371/journal.pone.0016379.


BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane.

Schug ZT, Gonzalvez F, Houtkooper RH, Vaz FM, Gottlieb E.

Cell Death Differ. 2011 Mar;18(3):538-48. doi: 10.1038/cdd.2010.135.

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