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Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.

Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K.

Nat Struct Mol Biol. 2018 Mar;25(3):225-232. doi: 10.1038/s41594-018-0036-6. Epub 2018 Feb 26.


Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.

Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, Wang M, Jiang L, Meng W, Cai W, Medvedovic M, Chen J, Paul C, Davidson WS, Sadayappan S, Stambrook PJ, Yu XY, Wang Y.

Nat Commun. 2018 Feb 16;9(1):700. doi: 10.1038/s41467-018-03019-z.


Dnd1-mediated epigenetic control of teratoma formation in mouse.

Gu W, Mochizuki K, Otsuka K, Hamada R, Takehara A, Matsui Y.

Biol Open. 2018 Jan 29;7(1). pii: bio032318. doi: 10.1242/bio.032318.


Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.

Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W.

Mol Cell. 2018 Jan 18;69(2):279-291.e5. doi: 10.1016/j.molcel.2017.12.024.


Structures of human PRC2 with its cofactors AEBP2 and JARID2.

Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E.

Science. 2018 Feb 23;359(6378):940-944. doi: 10.1126/science.aar5700. Epub 2018 Jan 18.


Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.

Boehm D, Ott M.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S8-S22. doi: 10.1089/aid.2017.0180.


The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.

Wang AH, Juan AH, Ko KD, Tsai PF, Zare H, Dell'Orso S, Sartorelli V.

Mol Cell. 2017 Oct 19;68(2):398-413.e6. doi: 10.1016/j.molcel.2017.09.016. Epub 2017 Oct 12.


PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.

Shan Y, Liang Z, Xing Q, Zhang T, Wang B, Tian S, Huang W, Zhang Y, Yao J, Zhu Y, Huang K, Liu Y, Wang X, Chen Q, Zhang J, Shang B, Li S, Shi X, Liao B, Zhang C, Lai K, Zhong X, Shu X, Wang J, Yao H, Chen J, Pei D, Pan G.

Nat Commun. 2017 Sep 22;8(1):672. doi: 10.1038/s41467-017-00668-4.


Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors.

Zhu MR, Du DH, Hu JC, Li LC, Liu JQ, Ding H, Kong XQ, Jiang HL, Chen KX, Luo C.

Acta Pharmacol Sin. 2018 Feb;39(2):302-310. doi: 10.1038/aps.2017.59. Epub 2017 Aug 31.


MUC1-C activates EZH2 expression and function in human cancer cells.

Rajabi H, Hiraki M, Tagde A, Alam M, Bouillez A, Christensen CL, Samur M, Wong KK, Kufe D.

Sci Rep. 2017 Aug 7;7(1):7481. doi: 10.1038/s41598-017-07850-0.


Polycomb repressive complex 2 in an autoinhibited state.

Bratkowski M, Yang X, Liu X.

J Biol Chem. 2017 Aug 11;292(32):13323-13332. doi: 10.1074/jbc.M117.787572. Epub 2017 Jun 12.


MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells.

Liu PP, Tang GB, Xu YJ, Zeng YQ, Zhang SF, Du HZ, Teng ZQ, Liu CM.

Stem Cell Reports. 2017 Jul 11;9(1):190-202. doi: 10.1016/j.stemcr.2017.05.007. Epub 2017 Jun 8.


Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy.

Gregory DJ, Kobzik L, Yang Z, McGuire CC, Fedulov AV.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L395-L405. doi: 10.1152/ajplung.00035.2017. Epub 2017 May 11.


Structure of the PRC2 complex and application to drug discovery.

Shi Y, Wang XX, Zhuang YW, Jiang Y, Melcher K, Xu HE.

Acta Pharmacol Sin. 2017 Jul;38(7):963-976. doi: 10.1038/aps.2017.7. Epub 2017 Apr 17. Review.


Inhibitors of Protein Methyltransferases and Demethylases.

Kaniskan HÜ, Martini ML, Jin J.

Chem Rev. 2018 Feb 14;118(3):989-1068. doi: 10.1021/acs.chemrev.6b00801. Epub 2017 Mar 24.


EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis.

Mu W, Starmer J, Shibata Y, Yee D, Magnuson T.

Dev Biol. 2017 Apr 15;424(2):198-207. doi: 10.1016/j.ydbio.2017.02.017. Epub 2017 Feb 28.


Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency.

Nguyen K, Das B, Dobrowolski C, Karn J.

MBio. 2017 Feb 28;8(1). pii: e00133-17. doi: 10.1128/mBio.00133-17.


Overexpression of suppressor of zest 12 is associated with cervical node metastasis and unfavorable prognosis in tongue squamous cell carcinoma.

Hu H, Wang Y, Li Z, Zhu Y, Zhang W, Wang D, Lin T, Yang J, Wang Y, Cheng J.

Cancer Cell Int. 2017 Feb 13;17:26. doi: 10.1186/s12935-017-0395-9. eCollection 2017.


Molecular architecture of polycomb repressive complexes.

Chittock EC, Latwiel S, Miller TC, Müller CW.

Biochem Soc Trans. 2017 Feb 8;45(1):193-205. doi: 10.1042/BST20160173. Review.


Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.

Li L, Zhang H, Zhang M, Zhao M, Feng L, Luo X, Gao Z, Huang Y, Ardayfio O, Zhang JH, Lin Y, Fan H, Mi Y, Li G, Liu L, Feng L, Luo F, Teng L, Qi W, Ottl J, Lingel A, Bussiere DE, Yu Z, Atadja P, Lu C, Li E, Gu J, Zhao K.

PLoS One. 2017 Jan 10;12(1):e0169855. doi: 10.1371/journal.pone.0169855. eCollection 2017.

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