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Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient.

Meumann EM, Globan M, Fyfe JA, Leslie D, Porter JL, Seemann T, Denholm J, Stinear TP.

Microb Genom. 2015 Nov 26;1(5):e000037. doi: 10.1099/mgen.0.000037. eCollection 2015 Nov.


Evaluation of para-Aminosalicylic Acid as a Substrate of Multiple Solute Carrier Uptake Transporters and Possible Drug Interactions with Nonsteroidal Anti-inflammatory Drugs In Vitro.

Parvez MM, Shin HJ, Jung JA, Shin JG.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02392-16. doi: 10.1128/AAC.02392-16. Print 2017 May.


A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt.

Fiebig L, Kohl TA, Popovici O, Mühlenfeld M, Indra A, Homorodean D, Chiotan D, Richter E, Rüsch-Gerdes S, Schmidgruber B, Beckert P, Hauer B, Niemann S, Allerberger F, Haas W.

Euro Surveill. 2017 Jan 12;22(2). pii: 30439. doi: 10.2807/1560-7917.ES.2017.22.2.30439.


Antibiotic resistance mechanisms in M. tuberculosis: an update.

Nguyen L.

Arch Toxicol. 2016 Jul;90(7):1585-604. doi: 10.1007/s00204-016-1727-6. Epub 2016 May 9. Review.


Drug Resistance Mechanisms in Mycobacterium tuberculosis.

Palomino JC, Martin A.

Antibiotics (Basel). 2014 Jul 2;3(3):317-40. doi: 10.3390/antibiotics3030317. Review.


Analysis of IS6110 insertion sites provide a glimpse into genome evolution of Mycobacterium tuberculosis.

Roychowdhury T, Mandal S, Bhattacharya A.

Sci Rep. 2015 Jul 28;5:12567. doi: 10.1038/srep12567.


Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.

Minato Y, Thiede JM, Kordus SL, McKlveen EJ, Turman BJ, Baughn AD.

Antimicrob Agents Chemother. 2015 Sep;59(9):5097-106. doi: 10.1128/AAC.00647-15. Epub 2015 Jun 1. Review.


Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.

Witney AA, Gould KA, Arnold A, Coleman D, Delgado R, Dhillon J, Pond MJ, Pope CF, Planche TD, Stoker NG, Cosgrove CA, Butcher PD, Harrison TS, Hinds J.

J Clin Microbiol. 2015 May;53(5):1473-83. doi: 10.1128/JCM.02993-14. Epub 2015 Feb 11.


Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012.

Zhang X, Liu L, Zhang Y, Dai G, Huang H, Jin Q.

Antimicrob Agents Chemother. 2015 Feb;59(2):1320-4. doi: 10.1128/AAC.03695-14. Epub 2014 Nov 24.


Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis.

de Kock L, Sy SK, Rosenkranz B, Diacon AH, Prescott K, Hernandez KR, Yu M, Derendorf H, Donald PR.

Antimicrob Agents Chemother. 2014 Oct;58(10):6242-50. doi: 10.1128/AAC.03073-14. Epub 2014 Aug 11.


Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis.

Zhao F, Wang XD, Erber LN, Luo M, Guo AZ, Yang SS, Gu J, Turman BJ, Gao YR, Li DF, Cui ZQ, Zhang ZP, Bi LJ, Baughn AD, Zhang XE, Deng JY.

Antimicrob Agents Chemother. 2014;58(3):1479-87. doi: 10.1128/AAC.01775-13. Epub 2013 Dec 23.


para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.

Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR.

J Biol Chem. 2013 Aug 9;288(32):23447-56. doi: 10.1074/jbc.M113.475798. Epub 2013 Jun 18. Erratum in: J Biol Chem. 2013 Oct 4;288(40):28951.


Comparative genomic analysis of Mycobacterium tuberculosis drug resistant strains from Russia.

Ilina EN, Shitikov EA, Ikryannikova LN, Alekseev DG, Kamashev DE, Malakhova MV, Parfenova TV, Afanas'ev MV, Ischenko DS, Bazaleev NA, Smirnova TG, Larionova EE, Chernousova LN, Beletsky AV, Mardanov AV, Ravin NV, Skryabin KG, Govorun VM.

PLoS One. 2013;8(2):e56577. doi: 10.1371/journal.pone.0056577. Epub 2013 Feb 20.


Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.

Chakraborty S, Gruber T, Barry CE 3rd, Boshoff HI, Rhee KY.

Science. 2013 Jan 4;339(6115):88-91. doi: 10.1126/science.1228980. Epub 2012 Nov 1.


Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis.

Wolff KA, Nguyen L.

Expert Rev Anti Infect Ther. 2012 Sep;10(9):971-81. doi: 10.1586/eri.12.87. Review.


Importance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistance.

Köser CU, Feuerriegel S, Summers DK, Archer JA, Niemann S.

Antimicrob Agents Chemother. 2012 Dec;56(12):6080-7. doi: 10.1128/AAC.01641-12. Epub 2012 Sep 24. Review.


The combination of sulfamethoxazole, trimethoprim, and isoniazid or rifampin is bactericidal and prevents the emergence of drug resistance in Mycobacterium tuberculosis.

Vilchèze C, Jacobs WR Jr.

Antimicrob Agents Chemother. 2012 Oct;56(10):5142-8. doi: 10.1128/AAC.00832-12. Epub 2012 Jul 23.


Real-time PCR using mycobacteriophage DNA for rapid phenotypic drug susceptibility results for Mycobacterium tuberculosis.

Pholwat S, Ehdaie B, Foongladda S, Kelly K, Houpt E.

J Clin Microbiol. 2012 Mar;50(3):754-61. doi: 10.1128/JCM.01315-11. Epub 2011 Dec 14.


Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.

Fivian-Hughes AS, Houghton J, Davis EO.

Microbiology. 2012 Feb;158(Pt 2):308-18. doi: 10.1099/mic.0.053983-0. Epub 2011 Oct 27. Erratum in: Microbiology. 2012 May;158(Pt 5):1388.


Bacterial conversion of folinic acid is required for antifolate resistance.

Ogwang S, Nguyen HT, Sherman M, Bajaksouzian S, Jacobs MR, Boom WH, Zhang GF, Nguyen L.

J Biol Chem. 2011 Apr 29;286(17):15377-90. doi: 10.1074/jbc.M111.231076. Epub 2011 Mar 3.

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