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ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus.

Ma P, Ren B, Yang X, Sun B, Liu X, Kong Q, Li C, Mao B.

Open Biol. 2017 Aug;7(8). pii: 170122. doi: 10.1098/rsob.170122. Epub 2017 Aug 16.


Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer.

Li Q, Li Z, Wei S, Wang W, Chen Z, Zhang L, Chen L, Li B, Sun G, Xu J, Li Q, Wang L, Xu Z, Xia Y, Zhang D, Xu H, Xu Z.

J Exp Clin Cancer Res. 2017 Apr 21;36(1):59. doi: 10.1186/s13046-017-0532-2.


USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7.

Kit Leng Lui S, Iyengar PV, Jaynes P, Isa ZFBA, Pang B, Tan TZ, Eichhorn PJA.

EMBO Rep. 2017 May;18(5):797-808. doi: 10.15252/embr.201643270. Epub 2017 Apr 5.


RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

Malonis RJ, Fu W, Jelcic MJ, Thompson M, Canter BS, Tsikitis M, Esteva FJ, Sánchez I.

J Biol Chem. 2017 May 5;292(18):7435-7451. doi: 10.1074/jbc.M117.783662. Epub 2017 Mar 14.


The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.

Lee CP, Liu GT, Kung HN, Liu PT, Liao YT, Chow LP, Chang LS, Chang YH, Chang CW, Shu WC, Angers A, Farina A, Lin SF, Tsai CH, Bouamr F, Chen MR.

J Virol. 2016 Sep 29;90(20):8994-9007. doi: 10.1128/JVI.01235-16. Print 2016 Oct 15.


Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer.

Goto Y, Kojima S, Kurozumi A, Kato M, Okato A, Matsushita R, Ichikawa T, Seki N.

Br J Cancer. 2016 May 10;114(10):1135-44. doi: 10.1038/bjc.2016.95. Epub 2016 Apr 12.


Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling.

Yan X, Liao H, Cheng M, Shi X, Lin X, Feng XH, Chen YG.

J Biol Chem. 2016 Jan 1;291(1):382-92. doi: 10.1074/jbc.M115.694281. Epub 2015 Nov 10.


Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma.

Zhang XF, Chao J, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Jiang SS, Chen CL, Zhang HX, Xia JC.

Oncotarget. 2015 Dec 1;6(38):40920-33. doi: 10.18632/oncotarget.5712.


Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.

Basheer WA, Harris BS, Mentrup HL, Abreha M, Thames EL, Lea JB, Swing DA, Copeland NG, Jenkins NA, Price RL, Matesic LE.

J Mol Cell Cardiol. 2015 Nov;88:1-13. doi: 10.1016/j.yjmcc.2015.09.004. Epub 2015 Sep 16.


Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.

Courivaud T, Ferrand N, Elkhattouti A, Kumar S, Levy L, Ferrigno O, Atfi A, Prunier C.

J Biol Chem. 2015 Aug 21;290(34):21007-18. doi: 10.1074/jbc.M115.642314. Epub 2015 Jul 7.


MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFβ signaling pathway via downregulation of WWP1.

Zuo K, Li M, Zhang X, Lu C, Wang S, Zhi K, He B.

Int J Clin Exp Pathol. 2015 Jan 1;8(1):414-22. eCollection 2015.


Regulation of TGF-β Signal Transduction.

Zhao B, Chen YG.

Scientifica (Cairo). 2014;2014:874065. doi: 10.1155/2014/874065. Epub 2014 Sep 23. Review.


The regulation of TGF-β/SMAD signaling by protein deubiquitination.

Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L, Zhou F.

Protein Cell. 2014 Jul;5(7):503-17. doi: 10.1007/s13238-014-0058-8. Epub 2014 Apr 23. Review.


WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.

Yeung B, Ho KC, Yang X.

PLoS One. 2013;8(4):e61027. doi: 10.1371/journal.pone.0061027. Epub 2013 Apr 3.


Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.

Zhang X, Zhang J, Bauer A, Zhang L, Selinger DW, Lu CX, Ten Dijke P.

EMBO J. 2013 Apr 3;32(7):996-1007. doi: 10.1038/emboj.2013.38. Epub 2013 Mar 1.


TGF-β - an excellent servant but a bad master.

Kubiczkova L, Sedlarikova L, Hajek R, Sevcikova S.

J Transl Med. 2012 Sep 3;10:183. doi: 10.1186/1479-5876-10-183. Review.


Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling.

Hirschhorn T, Barizilay L, Smorodinsky NI, Ehrlich M.

PLoS One. 2012;7(8):e43459. doi: 10.1371/journal.pone.0043459. Epub 2012 Aug 22.


Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

Al-Salihi MA, Herhaus L, Sapkota GP.

Open Biol. 2012 May;2(5):120082. doi: 10.1098/rsob.120082. Review.


Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity.

Zaarour RF, Chirivino D, Del Maestro L, Daviet L, Atfi A, Louvard D, Arpin M.

PLoS One. 2012;7(5):e37490. doi: 10.1371/journal.pone.0037490. Epub 2012 May 22.


Post-translational regulation of TGF-β receptor and Smad signaling.

Xu P, Liu J, Derynck R.

FEBS Lett. 2012 Jul 4;586(14):1871-84. doi: 10.1016/j.febslet.2012.05.010. Epub 2012 May 19. Review.

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