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The intranasal adjuvant Endocine™ enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen.

Falkeborn T, Hinkula J, Olliver M, Lindberg A, Maltais AK.

Virol J. 2017 Mar 3;14(1):44. doi: 10.1186/s12985-017-0698-4.


Vitamin D, leptin and impact on immune response to seasonal influenza A/H1N1 vaccine in older persons.

Sadarangani SP, Ovsyannikova IG, Goergen K, Grill DE, Poland GA.

Hum Vaccin Immunother. 2016 Mar 3;12(3):691-8. doi: 10.1080/21645515.2015.1097015.


Ageing and the immune system: focus on macrophages.

Linehan E, Fitzgerald DC.

Eur J Microbiol Immunol (Bp). 2015 Mar;5(1):14-24. doi: 10.1556/EUJMI-D-14-00035. Review.


A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody.

De Baets S, Verhelst J, Van den Hoecke S, Smet A, Schotsaert M, Job ER, Roose K, Schepens B, Fiers W, Saelens X.

PLoS One. 2015 Mar 27;10(3):e0121491. doi: 10.1371/journal.pone.0121491.


Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.

Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK.

Aging Cell. 2015 Jun;14(3):421-32. doi: 10.1111/acel.12320.


Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity.

Kulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K.

J Virol. 2014 Dec;88(24):13990-4001. doi: 10.1128/JVI.02273-14.


Asthma in the elderly: what we know and what we have yet to know.

Yáñez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedón JC, Canonica GW, Busse P, Boulet LP, Baena-Cagnani CE, Hamid Q, Bachert C, Pawankar R, Holgate ST.

World Allergy Organ J. 2014 May 30;7(1):8. doi: 10.1186/1939-4551-7-8. Review.


Animal models for influenza virus pathogenesis, transmission, and immunology.

Thangavel RR, Bouvier NM.

J Immunol Methods. 2014 Aug;410:60-79. doi: 10.1016/j.jim.2014.03.023. Review.


Taking stock of infections and antibiotic resistance in the elderly and long-term care facilities: A survey of existing and upcoming challenges.

Augustine S, Bonomo RA.

Eur J Microbiol Immunol (Bp). 2011 Sep;1(3):190-7. doi: 10.1556/EuJMI.1.2011.3.2. Review.


Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals.

Ovsyannikova IG, White SJ, Larrabee BR, Grill DE, Jacobson RM, Poland GA.

Vaccine. 2014 Feb 7;32(7):881-7. doi: 10.1016/j.vaccine.2013.12.009.


Impact of aging on antigen presentation cell function of dendritic cells.

Wong C, Goldstein DR.

Curr Opin Immunol. 2013 Aug;25(4):535-41. doi: 10.1016/j.coi.2013.05.016. Review.


Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections.

Zhao J, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB Jr, Perlman S.

J Virol. 2012 Nov;86(21):11416-24. doi: 10.1128/JVI.01410-12.


Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.

Reber AJ, Chirkova T, Kim JH, Cao W, Biber R, Shay DK, Sambhara S.

Aging Dis. 2012 Feb;3(1):68-90.


Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice.

Cummins NW, Weaver EA, May SM, Croatt AJ, Foreman O, Kennedy RB, Poland GA, Barry MA, Nath KA, Badley AD.

FASEB J. 2012 Jul;26(7):2911-8. doi: 10.1096/fj.11-190017.


Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections.

Poland GA, Ovsyannikova IG, Kennedy RB, Haralambieva IH, Jacobson RM.

OMICS. 2011 Sep;15(9):625-36. doi: 10.1089/omi.2011.0032. Review.


CD8 T cell responses to influenza virus infection in aged mice.

Jiang J, Fisher EM, Murasko DM.

Ageing Res Rev. 2011 Sep;10(4):422-7. doi: 10.1016/j.arr.2011.02.001. Review.


TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism.

Jones SC, Brahmakshatriya V, Huston G, Dibble J, Swain SL.

J Immunol. 2010 Dec 1;185(11):6783-94. doi: 10.4049/jimmunol.0901296.


Impact of aging on viral infections.

Leng J, Goldstein DR.

Microbes Infect. 2010 Dec;12(14-15):1120-4. doi: 10.1016/j.micinf.2010.08.009. Review.


Factors that may impact on immunosenescence: an appraisal.

Ongrádi J, Kövesdi V.

Immun Ageing. 2010 Jun 14;7:7. doi: 10.1186/1742-4933-7-7.

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