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Items: 1 to 20 of 71


In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery.

Huang DT, Lu CY, Shao PL, Chang LY, Wang JY, Chang YH, Lai MJ, Chi YH, Huang LM.

PLoS One. 2017 Apr 5;12(4):e0174523. doi: 10.1371/journal.pone.0174523. eCollection 2017.


Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection.

Timin AS, Muslimov AR, Petrova AV, Lepik KV, Okilova MV, Vasin AV, Afanasyev BV, Sukhorukov GB.

Sci Rep. 2017 Mar 7;7(1):102. doi: 10.1038/s41598-017-00200-0.


The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design.

Stevaert A, Naesens L.

Med Res Rev. 2016 Nov;36(6):1127-1173. doi: 10.1002/med.21401. Epub 2016 Aug 29. Review.


Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome.

Wang S, Chen C, Yang Z, Chi X, Zhang J, Chen JL.

Sci Rep. 2016 Apr 1;6:23746. doi: 10.1038/srep23746.


Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance.

Wee KB, Lee RT, Lin J, Pramono ZA, Maurer-Stroh S.

PLoS Comput Biol. 2016 Jan 15;12(1):e1004663. doi: 10.1371/journal.pcbi.1004663. eCollection 2016 Jan.


Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines.

Park J, Park J, Pei Y, Xu J, Yeo Y.

Adv Drug Deliv Rev. 2016 Sep 1;104:93-109. doi: 10.1016/j.addr.2015.12.004. Epub 2015 Dec 10. Review.


A Conserved Secondary Structural Element in the Coding Region of the Influenza A Virus Nucleoprotein (NP) mRNA Is Important for the Regulation of Viral Proliferation.

Soszynska-Jozwiak M, Michalak P, Moss WN, Kierzek R, Kierzek E.

PLoS One. 2015 Oct 21;10(10):e0141132. doi: 10.1371/journal.pone.0141132. eCollection 2015.


Combination of specific single chain antibody variable fragment and siRNA has a synergistic inhibitory effect on the propagation of avian influenza virus H5N1 in chicken cells.

Wang S, Zhang P, He F, Wang JG, Sun JZ, Li ZL, Yi B, Xi J, Mao YP, Hou Q, Yuan DL, Zhang ZD, Liu WQ.

Virol J. 2014 Nov 29;11:208. doi: 10.1186/s12985-014-0208-x.


Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia.

Krishnamurthy S, Behlke MA, Apicella MA, McCray PB Jr, Davidson BL.

Mol Ther Nucleic Acids. 2014 Jul 15;3:e175. doi: 10.1038/mtna.2014.26.


Drosha as an interferon-independent antiviral factor.

Shapiro JS, Schmid S, Aguado LC, Sabin LR, Yasunaga A, Shim JV, Sachs D, Cherry S, tenOever BR.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7108-13. doi: 10.1073/pnas.1319635111. Epub 2014 Apr 28.


Gene silencing of β-galactosamide α-2,6-sialyltransferase 1 inhibits human influenza virus infection of airway epithelial cells.

Wu D, Huang W, Wang Y, Guan W, Li R, Yang Z, Zhong N.

BMC Microbiol. 2014 Mar 27;14:78. doi: 10.1186/1471-2180-14-78.


RNAi Therapeutic Platforms for Lung Diseases.

Fujita Y, Takeshita F, Kuwano K, Ochiya T.

Pharmaceuticals (Basel). 2013 Feb 6;6(2):223-50. doi: 10.3390/ph6020223.


Gene regulation by non-coding RNAs.

Patil VS, Zhou R, Rana TM.

Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):16-32. doi: 10.3109/10409238.2013.844092. Epub 2013 Oct 28. Review.


siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway.

Sui H, Zhou M, Chen Q, Lane HC, Imamichi T.

Nucleic Acids Res. 2014 Jan;42(1):583-98. doi: 10.1093/nar/gkt844. Epub 2013 Sep 18.


Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases.

Kedinger V, Meulle A, Zounib O, Bonnet ME, Gossart JB, Benoit E, Messmer M, Shankaranarayanan P, Behr JP, Erbacher P, Bolcato-Bellemin AL.

BMC Cancer. 2013 Jul 9;13:338. doi: 10.1186/1471-2407-13-338.


Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA.

McCaskill J, Singhania R, Burgess M, Allavena R, Wu S, Blumenthal A, McMillan NA.

Mol Ther Nucleic Acids. 2013 Jun 4;2:e96. doi: 10.1038/mtna.2013.22.


Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro.

Ramachandran S, Krishnamurthy S, Jacobi AM, Wohlford-Lenane C, Behlke MA, Davidson BL, McCray PB Jr.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1;305(1):L23-32. doi: 10.1152/ajplung.00426.2012. Epub 2013 Apr 26.


Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages.

Wilson AA, Kwok LW, Porter EL, Payne JG, McElroy GS, Ohle SJ, Greenhill SR, Blahna MT, Yamamoto K, Jean JC, Mizgerd JP, Kotton DN.

Mol Ther. 2013 Apr;21(4):825-33. doi: 10.1038/mt.2013.19. Epub 2013 Feb 12.


Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia.

Krishnamurthy S, Behlke MA, Ramachandran S, Salem AK, McCray PB Jr, Davidson BL.

Mol Ther Nucleic Acids. 2012 Aug 28;1:e41. doi: 10.1038/mtna.2012.36.

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