Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 31

1.

Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.

Liu CS, Yang-Yen HF, Suen CS, Hwang MJ, Yen JJ.

Sci Rep. 2017 Jul 4;7(1):4613. doi: 10.1038/s41598-017-04078-w.

2.

The role of the Exon 13 G571S JAK2 mutation in myeloproliferative neoplasms.

Bahar B, Barton K, Kini AR.

Leuk Res Rep. 2016 Jul 25;6:27-28. eCollection 2016.

3.
4.

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms.

Silvennoinen O, Hubbard SR.

Blood. 2015 May 28;125(22):3388-92. doi: 10.1182/blood-2015-01-621110. Epub 2015 Mar 30. Review.

5.

The molecular regulation of Janus kinase (JAK) activation.

Babon JJ, Lucet IS, Murphy JM, Nicola NA, Varghese LN.

Biochem J. 2014 Aug 15;462(1):1-13. doi: 10.1042/BJ20140712. Review.

6.

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.

Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammarén H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR.

Nat Struct Mol Biol. 2014 Jul;21(7):579-84. doi: 10.1038/nsmb.2849. Epub 2014 Jun 11.

7.

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Varghese LN, Ungureanu D, Liau NP, Young SN, Laktyushin A, Hammaren H, Lucet IS, Nicola NA, Silvennoinen O, Babon JJ, Murphy JM.

Biochem J. 2014 Mar 1;458(2):395-405. doi: 10.1042/BJ20131516.

8.

Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells.

Chen X, Ying Z, Lin X, Lin H, Wu J, Li M, Song L.

J Clin Invest. 2013 Jun;123(6):2576-89. doi: 10.1172/JCI68143. Epub 2013 May 8.

9.

JAK Kinases in Health and Disease: An Update.

Laurence A, Pesu M, Silvennoinen O, O'Shea J.

Open Rheumatol J. 2012;6:232-44. doi: 10.2174/1874312901206010232. Epub 2012 Sep 7.

10.

Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice.

Yan D, Hutchison RE, Mohi G.

Blood. 2012 Aug 30;120(9):1888-98. doi: 10.1182/blood-2011-09-380808. Epub 2012 Jul 26.

11.

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR.

Nat Struct Mol Biol. 2012 Aug;19(8):754-9. doi: 10.1038/nsmb.2348. Epub 2012 Jul 22.

12.

Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish.

Onnebo SM, Rasighaemi P, Kumar J, Liongue C, Ward AC.

Haematologica. 2012 Dec;97(12):1895-903. doi: 10.3324/haematol.2012.064659. Epub 2012 Jun 24.

13.

Biology and significance of the JAK/STAT signalling pathways.

Kiu H, Nicholson SE.

Growth Factors. 2012 Apr;30(2):88-106. doi: 10.3109/08977194.2012.660936. Epub 2012 Feb 20. Review.

14.

Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis.

Looi CY, Imanishi M, Takaki S, Sato M, Chiba N, Sasahara Y, Futaki S, Tsuchiya S, Kumaki S.

PLoS One. 2011;6(8):e23640. doi: 10.1371/journal.pone.0023640. Epub 2011 Aug 10.

15.

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.

Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O.

Nat Struct Mol Biol. 2011 Aug 14;18(9):971-6. doi: 10.1038/nsmb.2099.

16.

Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation.

Sayyah J, Gnanasambandan K, Kamarajugadda S, Tsuda S, Caldwell-Busby J, Sayeski PP.

Cell Signal. 2011 Nov;23(11):1806-15. doi: 10.1016/j.cellsig.2011.06.015. Epub 2011 Jun 29.

17.

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.

Argetsinger LS, Stuckey JA, Robertson SA, Koleva RI, Cline JM, Marto JA, Myers MG Jr, Carter-Su C.

Mol Endocrinol. 2010 May;24(5):1062-76. doi: 10.1210/me.2009-0355. Epub 2010 Mar 19.

18.

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

Treebak JT, Taylor EB, Witczak CA, An D, Toyoda T, Koh HJ, Xie J, Feener EP, Wojtaszewski JF, Hirshman MF, Goodyear LJ.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C377-85. doi: 10.1152/ajpcell.00297.2009. Epub 2009 Nov 18.

19.

JAK redux: a second look at the regulation and role of JAKs in the heart.

Kurdi M, Booz GW.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1545-56. doi: 10.1152/ajpheart.00032.2009. Epub 2009 Aug 28. Review.

20.

A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.

Zhao L, Dong H, Zhang CC, Kinch L, Osawa M, Iacovino M, Grishin NV, Kyba M, Huang LJ.

J Biol Chem. 2009 Sep 25;284(39):26988-98. doi: 10.1074/jbc.M109.011387. Epub 2009 Jul 28.

Supplemental Content

Support Center