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Items: 15

1.

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

Chen L, Ge B, Casale FP, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yan Y, Kundu K, Ecker S, Datta A, Richardson D, Burden F, Mead D, Mann AL, Fernandez JM, Rowlston S, Wilder SP, Farrow S, Shao X, Lambourne JJ, Redensek A, Albers CA, Amstislavskiy V, Ashford S, Berentsen K, Bomba L, Bourque G, Bujold D, Busche S, Caron M, Chen SH, Cheung W, Delaneau O, Dermitzakis ET, Elding H, Colgiu I, Bagger FO, Flicek P, Habibi E, Iotchkova V, Janssen-Megens E, Kim B, Lehrach H, Lowy E, Mandoli A, Matarese F, Maurano MT, Morris JA, Pancaldi V, Pourfarzad F, Rehnstrom K, Rendon A, Risch T, Sharifi N, Simon MM, Sultan M, Valencia A, Walter K, Wang SY, Frontini M, Antonarakis SE, Clarke L, Yaspo ML, Beck S, Guigo R, Rico D, Martens JH, Ouwehand WH, Kuijpers TW, Paul DS, Stunnenberg HG, Stegle O, Downes K, Pastinen T, Soranzo N.

Cell. 2016 Nov 17;167(5):1398-1414.e24. doi: 10.1016/j.cell.2016.10.026.

2.

Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium.

Chen CY, Leu YL, Fang Y, Lin CF, Kuo LM, Sung WC, Tsai YF, Chung PJ, Lee MC, Kuo YT, Yang HW, Hwang TL.

Sci Rep. 2015 Dec 14;5:18204. doi: 10.1038/srep18204.

3.

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism.

Rotin LE, Gronda M, MacLean N, Hurren R, Wang X, Lin FH, Wrana J, Datti A, Barber DL, Minden MD, Slassi M, Schimmer AD.

Oncotarget. 2016 Jan 19;7(3):2765-79. doi: 10.18632/oncotarget.6409.

4.

Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer.

Kokabee L, Wang X, Sevinsky CJ, Wang WL, Cheu L, Chittur SV, Karimipoor M, Tenniswood M, Conklin DS.

Cancer Biol Ther. 2015;16(11):1604-15. doi: 10.1080/15384047.2015.1078023. Epub 2015 Sep 18.

5.

Targets for Ibrutinib Beyond B Cell Malignancies.

Berglöf A, Hamasy A, Meinke S, Palma M, Krstic A, Månsson R, Kimby E, Österborg A, Smith CI.

Scand J Immunol. 2015 Sep;82(3):208-17. doi: 10.1111/sji.12333. Review.

6.

The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.

Zwolanek F, Riedelberger M, Stolz V, Jenull S, Istel F, Köprülü AD, Ellmeier W, Kuchler K.

PLoS Pathog. 2014 Dec 4;10(12):e1004525. doi: 10.1371/journal.ppat.1004525. eCollection 2014 Dec.

7.

Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma.

Wu H, Wang W, Liu F, Weisberg EL, Tian B, Chen Y, Li B, Wang A, Wang B, Zhao Z, McMillin DW, Hu C, Li H, Wang J, Liang Y, Buhrlage SJ, Liang J, Liu J, Yang G, Brown JR, Treon SP, Mitsiades CS, Griffin JD, Liu Q, Gray NS.

ACS Chem Biol. 2014 May 16;9(5):1086-91. doi: 10.1021/cb4008524. Epub 2014 Mar 17.

8.

Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells.

Mathews LA, Hurt EM, Zhang X, Farrar WL.

Mol Cancer. 2010 Oct 7;9:267. doi: 10.1186/1476-4598-9-267.

9.

Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis.

Jones D, Xu Z, Zhang H, He Y, Kluger MS, Chen H, Min W.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2553-61. doi: 10.1161/ATVBAHA.110.214999. Epub 2010 Sep 23.

10.

Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.

Lenox LE, Kambayashi T, Okumura M, Prieto C, Sauer K, Bunte RM, Jordan MS, Koretzky GA, Nichols KE.

J Allergy Clin Immunol. 2009 Nov;124(5):1088-98. doi: 10.1016/j.jaci.2009.08.038.

11.

ITK inhibitors in inflammation and immune-mediated disorders.

Sahu N, August A.

Curr Top Med Chem. 2009;9(8):690-703. Review.

12.

Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.

Readinger JA, Mueller KL, Venegas AM, Horai R, Schwartzberg PL.

Immunol Rev. 2009 Mar;228(1):93-114. doi: 10.1111/j.1600-065X.2008.00757.x. Review.

13.

Conformational snapshots of Tec kinases during signaling.

Joseph RE, Andreotti AH.

Immunol Rev. 2009 Mar;228(1):74-92. doi: 10.1111/j.1600-065X.2008.00740.x.

14.

Selective targeting of ITK blocks multiple steps of HIV replication.

Readinger JA, Schiralli GM, Jiang JK, Thomas CJ, August A, Henderson AJ, Schwartzberg PL.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6684-9. doi: 10.1073/pnas.0709659105. Epub 2008 Apr 28.

15.

The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation.

Lee SH, Kim T, Jeong D, Kim N, Choi Y.

J Biol Chem. 2008 Apr 25;283(17):11526-34. doi: 10.1074/jbc.M708935200. Epub 2008 Feb 14.

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