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Items: 16


Evolutionary aspects of enzyme dynamics.

Klinman JP, Kohen A.

J Biol Chem. 2014 Oct 31;289(44):30205-12. doi: 10.1074/jbc.R114.565515. Epub 2014 Sep 10. Review.


Yeast alcohol dehydrogenase structure and catalysis.

Raj SB, Ramaswamy S, Plapp BV.

Biochemistry. 2014 Sep 16;53(36):5791-803. doi: 10.1021/bi5006442. Epub 2014 Sep 3.


Hydrogen tunneling links protein dynamics to enzyme catalysis.

Klinman JP, Kohen A.

Annu Rev Biochem. 2013;82:471-96. doi: 10.1146/annurev-biochem-051710-133623. Review.


Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases.

Nagel ZD, Cun S, Klinman JP.

J Biol Chem. 2013 May 17;288(20):14087-97. doi: 10.1074/jbc.M113.453951. Epub 2013 Mar 22.


Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol.

Liu X, Bastian S, Snow CD, Brustad EM, Saleski TE, Xu JH, Meinhold P, Arnold FH.

J Biotechnol. 2012 Dec 15;164(2):188-95. doi: 10.1016/j.jbiotec.2012.08.008. Epub 2012 Sep 3.


Functional divergence of FimX in PilZ binding and type IV pilus regulation.

Qi Y, Xu L, Dong X, Yau YH, Ho CL, Koh SL, Shochat SG, Chou SH, Tang K, Liang ZX.

J Bacteriol. 2012 Nov;194(21):5922-31. doi: 10.1128/JB.00767-12. Epub 2012 Aug 31.


Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.

Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP.

Biochemistry. 2012 May 22;51(20):4147-56. doi: 10.1021/bi3001352. Epub 2012 May 8.


Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors.

Nagel ZD, Dong M, Bahnson BJ, Klinman JP.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10520-5. doi: 10.1073/pnas.1104989108. Epub 2011 Jun 13.


Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.

Nagel ZD, Klinman JP.

Chem Rev. 2010 Dec 8;110(12):PR41-67. doi: 10.1021/cr1001035. No abstract available.


The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase.

Rao F, Qi Y, Chong HS, Kotaka M, Li B, Li J, Lescar J, Tang K, Liang ZX.

J Bacteriol. 2009 Aug;191(15):4722-31. doi: 10.1128/JB.00327-09. Epub 2009 Apr 17.


Purification and characterization of a novel recombinant highly enantioselective short-chain NAD(H)-dependent alcohol dehydrogenase from Thermus thermophilus.

Pennacchio A, Pucci B, Secundo F, La Cara F, Rossi M, Raia CA.

Appl Environ Microbiol. 2008 Jul;74(13):3949-58. doi: 10.1128/AEM.00217-08. Epub 2008 May 2.


Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.

Klinman JP.

Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1323-31.


Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase.

Liang ZX, Lee T, Resing KA, Ahn NG, Klinman JP.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9556-61. Epub 2004 Jun 21.

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