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Protein neddylation and its alterations in human cancers for targeted therapy.

Zhou L, Zhang W, Sun Y, Jia L.

Cell Signal. 2018 Apr;44:92-102. doi: 10.1016/j.cellsig.2018.01.009. Epub 2018 Jan 10. Review.


Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.

Singh RK, Kazansky Y, Wathieu D, Fushman D.

Anal Chem. 2017 Aug 1;89(15):7852-7860. doi: 10.1021/acs.analchem.6b04194. Epub 2017 Jul 20.


Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.

Lv Z, Yuan L, Atkison JH, Aldana-Masangkay G, Chen Y, Olsen SK.

J Biol Chem. 2017 Jul 21;292(29):12089-12099. doi: 10.1074/jbc.M117.787622. Epub 2017 Jun 1.


Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence.

Padala P, Oweis W, Mashahreh B, Soudah N, Cohen-Kfir E, Todd EA, Berndsen CE, Wiener R.

Sci Rep. 2017 Mar 30;7(1):508. doi: 10.1038/s41598-017-00610-0.


Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.

Cappadocia L, Lima CD.

Chem Rev. 2018 Feb 14;118(3):889-918. doi: 10.1021/acs.chemrev.6b00737. Epub 2017 Feb 24.


Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions.

Liu B, Lois LM, Reverter D.

Sci Rep. 2017 Feb 6;7:41998. doi: 10.1038/srep41998.


Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach.

Tan KL, Pezzella F.

Oncol Lett. 2016 Dec;12(6):4287-4296. doi: 10.3892/ol.2016.5232. Epub 2016 Oct 6.


A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H.

Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16.


Specificity and disease in the ubiquitin system.

Chaugule VK, Walden H.

Biochem Soc Trans. 2016 Feb;44(1):212-27. doi: 10.1042/BST20150209. Review.


A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.

Taylor JY, Schwander K, Kardia SL, Arnett D, Liang J, Hunt SC, Rao DC, Sun YV.

Sci Rep. 2016 Jan 11;6:18812. doi: 10.1038/srep18812.


Positional plasticity in regenerating Amybstoma mexicanum limbs is associated with cell proliferation and pathways of cellular differentiation.

McCusker CD, Athippozhy A, Diaz-Castillo C, Fowlkes C, Gardiner DM, Voss SR.

BMC Dev Biol. 2015 Nov 23;15:45. doi: 10.1186/s12861-015-0095-4.


Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery.

Schelpe J, Monté D, Dewitte F, Sixma TK, Rucktooa P.

J Biol Chem. 2016 Jan 8;291(2):630-9. doi: 10.1074/jbc.M115.671545. Epub 2015 Nov 10.


Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.

Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X.

Oncotarget. 2015 Dec 8;6(39):41809-24. doi: 10.18632/oncotarget.6166.


The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair.

Chung D, Dellaire G.

Biomolecules. 2015 Sep 30;5(4):2388-416. doi: 10.3390/biom5042388. Review.


RWD Domain as an E2 (Ubc9)-Interaction Module.

Alontaga AY, Ambaye ND, Li YJ, Vega R, Chen CH, Bzymek KP, Williams JC, Hu W, Chen Y.

J Biol Chem. 2015 Jul 3;290(27):16550-9. doi: 10.1074/jbc.M115.644047. Epub 2015 Apr 27.


Ubiquitylation, neddylation and the DNA damage response.

Brown JS, Jackson SP.

Open Biol. 2015 Apr;5(4):150018. doi: 10.1098/rsob.150018. Review.


Cycle on Wheels: Is APP Key to the AppBp1 Pathway?

Chen Y, Neve R, Zheng H, Griffin W, Barger S, Mrak R.

Austin Alzheimers Parkinsons Dis. 2014;1(2). pii: id1008.


Protein neddylation: beyond cullin-RING ligases.

Enchev RI, Schulman BA, Peter M.

Nat Rev Mol Cell Biol. 2015 Jan;16(1):30-44. doi: 10.1038/nrm3919. Review.


Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.

Gavin JM, Hoar K, Xu Q, Ma J, Lin Y, Chen J, Chen W, Bruzzese FJ, Harrison S, Mallender WD, Bump NJ, Sintchak MD, Bence NF, Li P, Dick LR, Gould AE, Chen JJ.

J Biol Chem. 2014 Aug 15;289(33):22648-58. doi: 10.1074/jbc.M114.573972. Epub 2014 Jun 25.


Perilous journey: a tour of the ubiquitin-proteasome system.

Kleiger G, Mayor T.

Trends Cell Biol. 2014 Jun;24(6):352-9. doi: 10.1016/j.tcb.2013.12.003. Epub 2014 Jan 20. Review.

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