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Items: 1 to 20 of 31


Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum.

Shahheydari H, Ragagnin A, Walker AK, Toth RP, Vidal M, Jagaraj CJ, Perri ER, Konopka A, Sultana JM, Atkin JD.

Front Mol Neurosci. 2017 May 10;10:119. doi: 10.3389/fnmol.2017.00119. eCollection 2017.


Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling.

Cheng M, Xue H, Cao W, Li W, Chen H, Liu B, Ma B, Yan X, Chen YG.

J Biol Chem. 2016 Jun 10;291(24):12871-9. doi: 10.1074/jbc.M115.708818. Epub 2016 Apr 20.


Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases.

Boomsma W, Nielsen SV, Lindorff-Larsen K, Hartmann-Petersen R, Ellgaard L.

PeerJ. 2016 Feb 25;4:e1725. doi: 10.7717/peerj.1725. eCollection 2016.


Novel somatic mutations identified by whole-exome sequencing in muscle-invasive transitional cell carcinoma of the bladder.

Pan H, Xu X, Wu D, Qiu Q, Zhou S, He X, Zhou Y, Qu P, Hou J, He J, Zhou J.

Oncol Lett. 2016 Feb;11(2):1486-1492. Epub 2016 Jan 8.


Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.

Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, Yamaguchi TP, Ohba Y, Hatakeyama S.

Mol Cell Biol. 2015 Jun 1;35(11):2007-23. doi: 10.1128/MCB.00159-15. Epub 2015 Mar 30.


Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome.

Bunn KJ, Daniel P, Rösken HS, O'Neill AC, Cameron-Christie SR, Morgan T, Brunner HG, Lai A, Kunst HP, Markie DM, Robertson SP.

Am J Hum Genet. 2015 Apr 2;96(4):623-30. doi: 10.1016/j.ajhg.2015.02.010. Epub 2015 Mar 26.


Suppression of BRCA1 sensitizes cells to proteasome inhibitors.

Gu Y, Bouwman P, Greco D, Saarela J, Yadav B, Jonkers J, Kuznetsov SG.

Cell Death Dis. 2014 Dec 18;5:e1580. doi: 10.1038/cddis.2014.537.


Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.

Landré V, Rotblat B, Melino S, Bernassola F, Melino G.

Oncotarget. 2014 Sep 30;5(18):7988-8013. Review.


Ubiquitin pathways in neurodegenerative disease.

Atkin G, Paulson H.

Front Mol Neurosci. 2014 Jul 8;7:63. doi: 10.3389/fnmol.2014.00063. eCollection 2014. Review.


Apoptotic cell death in neuroblastoma.

Li Y, Nakagawara A.

Cells. 2013 Jun 20;2(2):432-59. doi: 10.3390/cells2020432.


Regulation of Wnt/β-catenin signaling by posttranslational modifications.

Gao C, Xiao G, Hu J.

Cell Biosci. 2014 Mar 4;4(1):13. doi: 10.1186/2045-3701-4-13.


The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

Lu L, Hu S, Wei R, Qiu X, Lu K, Fu Y, Li H, Xing G, Li D, Peng R, He F, Zhang L.

J Biol Chem. 2013 Dec 13;288(50):35637-50. doi: 10.1074/jbc.M113.472076. Epub 2013 Oct 25.


HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation.

Ding Y, Zhang Y, Xu C, Tao QH, Chen YG.

J Biol Chem. 2013 Mar 22;288(12):8289-98. doi: 10.1074/jbc.M112.433185. Epub 2013 Feb 9.


AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity.

Kwan HT, Chan DW, Cai PC, Mak CS, Yung MM, Leung TH, Wong OG, Cheung AN, Ngan HY.

PLoS One. 2013;8(1):e53597. doi: 10.1371/journal.pone.0053597. Epub 2013 Jan 2.


The way Wnt works: components and mechanism.

Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E.

Growth Factors. 2013 Feb;31(1):1-31. doi: 10.3109/08977194.2012.752737. Epub 2012 Dec 21. Review.


The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.

Wei W, Li M, Wang J, Nie F, Li L.

Mol Cell Biol. 2012 Oct;32(19):3903-12. doi: 10.1128/MCB.00251-12. Epub 2012 Jul 23.


Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.

Nethe M, de Kreuk BJ, Tauriello DV, Anthony EC, Snoek B, Stumpel T, Salinas PC, Maurice MM, Geerts D, Deelder AM, Hensbergen PJ, Hordijk PL.

J Cell Sci. 2012 Jul 15;125(Pt 14):3430-42. doi: 10.1242/jcs.100925. Epub 2012 Mar 30.


The ubiquitin-proteasome system meets angiogenesis.

Rahimi N.

Mol Cancer Ther. 2012 Mar;11(3):538-48. doi: 10.1158/1535-7163.MCT-11-0555. Epub 2012 Feb 21. Review.


Malin regulates Wnt signaling pathway through degradation of dishevelled2.

Sharma J, Mulherkar S, Mukherjee D, Jana NR.

J Biol Chem. 2012 Feb 24;287(9):6830-9. doi: 10.1074/jbc.M111.315135. Epub 2012 Jan 5.


Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.

Chang HC, Paek J, Kim DH.

Nature. 2011 Nov 16;480(7378):525-9. doi: 10.1038/nature10643.

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