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Items: 1 to 20 of 37

1.

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.

Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC.

Cancer Cell. 2017 May 8;31(5):685-696.e6. doi: 10.1016/j.ccell.2017.04.002.

PMID:
28486107
2.

One-way membrane trafficking of SOS in receptor-triggered Ras activation.

Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT.

Nat Struct Mol Biol. 2016 Sep;23(9):838-46. doi: 10.1038/nsmb.3275. Epub 2016 Aug 8.

3.

Kras Is Critical for B Cell Lymphopoiesis.

Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, Zhou F, Zhu W, Wu Z, Zhang J, Wen R, Wang D.

J Immunol. 2016 Feb 15;196(4):1678-85. doi: 10.4049/jimmunol.1502112. Epub 2016 Jan 15.

4.

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.

Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW.

J Exp Med. 2015 Sep 21;212(10):1693-708. doi: 10.1084/jem.20141271. Epub 2015 Aug 31.

5.

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP.

Nat Cell Biol. 2015 Jun;17(6):804-15. doi: 10.1038/ncb3175. Epub 2015 May 25.

6.

RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.

Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, Li N, Cao X, Wang J.

Nat Commun. 2014 Aug 14;5:4657. doi: 10.1038/ncomms5657.

7.

Function of RasGRP3 in the formation and progression of human breast cancer.

Nagy Z, Kovács I, Török M, Tóth D, Vereb G, Buzás K, Juhász I, Blumberg PM, Bíró T, Czifra G.

Mol Cancer. 2014 Apr 29;13:96. doi: 10.1186/1476-4598-13-96.

8.

RasGRP Ras guanine nucleotide exchange factors in cancer.

Ksionda O, Limnander A, Roose JP.

Front Biol (Beijing). 2013 Oct 1;8(5):508-532.

9.

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.

Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E.

Mol Cell Biol. 2013 Nov;33(22):4562-78. doi: 10.1128/MCB.01026-13. Epub 2013 Sep 16.

10.

Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.

Jun JE, Rubio I, Roose JP.

Front Immunol. 2013 Sep 4;4:239. doi: 10.3389/fimmu.2013.00239. Review.

11.

Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP.

Mol Cell Biol. 2013 Jun;33(12):2470-84. doi: 10.1128/MCB.01593-12. Epub 2013 Apr 15.

12.

Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.

Miyazaki A, Yogosawa S, Murakami A, Kitamura D.

PLoS One. 2012;7(2):e31829. doi: 10.1371/journal.pone.0031829. Epub 2012 Feb 21.

13.

Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells.

Limnander A, Weiss A.

Small GTPases. 2011 Sep;2(5):282-288. Epub 2011 Sep 1.

14.

The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.

Zhu M, Fuller DM, Zhang W.

J Biol Chem. 2012 Mar 9;287(11):8135-43. doi: 10.1074/jbc.M111.320580. Epub 2012 Jan 19.

15.

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.

Stone JC.

Genes Cancer. 2011 Mar;2(3):320-34. doi: 10.1177/1947601911408082.

16.

CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway.

Kometani K, Yamada T, Sasaki Y, Yokosuka T, Saito T, Rajewsky K, Ishiai M, Hikida M, Kurosaki T.

J Exp Med. 2011 Jul 4;208(7):1447-57. doi: 10.1084/jem.20102665. Epub 2011 Jun 27.

17.

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.

Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM.

Oncogene. 2011 Nov 10;30(45):4590-4600. doi: 10.1038/onc.2011.166. Epub 2011 May 23.

18.

The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.

Randhawa PK, Rylova S, Heinz JY, Kiser S, Fried JH, Dunworth WP, Anderson AL, Barber AT, Chappell JC, Roberts DM, Bautch VL.

Circ Res. 2011 May 13;108(10):1199-208. doi: 10.1161/CIRCRESAHA.110.230888. Epub 2011 Apr 7.

19.

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A.

Nat Immunol. 2011 May;12(5):425-33. doi: 10.1038/ni.2016. Epub 2011 Mar 27.

20.

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.

Ackermann JA, Radtke D, Maurberger A, Winkler TH, Nitschke L.

EMBO J. 2011 Apr 20;30(8):1621-33. doi: 10.1038/emboj.2011.74. Epub 2011 Mar 22.

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