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Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production.

Shinde P, Liu W, Ménoret A, Luster AD, Vella AT.

J Leukoc Biol. 2017 Apr 21. pii: jlb.1A0616-261RR. doi: 10.1189/jlb.1A0616-261RR. [Epub ahead of print]


PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages.

Zuniga MC, Raghuraman G, Hitchner E, Weyand C, Robinson W, Zhou W.

Atherosclerosis. 2017 Apr;259:51-59. doi: 10.1016/j.atherosclerosis.2017.02.021. Epub 2017 Feb 24.


TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF) Regulates CXCR5+ T helper Cells in the Intestine.

Kanagavelu S, Flores C, Hagiwara S, Ruiz J, Hyun J, Cho EE, Sun F, Romero L, Shih DQ, Fukata M.

J Clin Cell Immunol. 2016 Oct;7(5). pii: 458. Epub 2016 Sep 30.


Adjuvants for peptide-based cancer vaccines.

Khong H, Overwijk WW.

J Immunother Cancer. 2016 Sep 20;4:56. doi: 10.1186/s40425-016-0160-y. eCollection 2016. Review.


Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling.

Pinilla-Vera M, Xiong Z, Zhao Y, Zhao J, Donahoe MP, Barge S, Horne WT, Kolls JK, McVerry BJ, Birukova A, Tighe RM, Foster WM, Hollingsworth J, Ray A, Mallampalli R, Ray P, Lee JS.

PLoS One. 2016 Jul 19;11(7):e0159329. doi: 10.1371/journal.pone.0159329. eCollection 2016.


STAT2 Is Required for TLR-Induced Murine Dendritic Cell Activation and Cross-Presentation.

Xu J, Lee MH, Chakhtoura M, Green BL, Kotredes KP, Chain RW, Sriram U, Gamero AM, Gallucci S.

J Immunol. 2016 Jul 1;197(1):326-36. doi: 10.4049/jimmunol.1500152. Epub 2016 May 27.


Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling.

Kramann N, Menken L, Hayardeny L, Hanisch UK, Brück W.

Neurol Neuroimmunol Neuroinflamm. 2016 May 17;3(3):e233. doi: 10.1212/NXI.0000000000000233. eCollection 2016 Jun.


The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.

Carroll EC, Jin L, Mori A, Muñoz-Wolf N, Oleszycka E, Moran HB, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC.

Immunity. 2016 Mar 15;44(3):597-608. doi: 10.1016/j.immuni.2016.02.004. Epub 2016 Mar 2.


The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction.

Dubois Cauwelaert N, Desbien AL, Hudson TE, Pine SO, Reed SG, Coler RN, Orr MT.

PLoS One. 2016 Jan 5;11(1):e0146372. doi: 10.1371/journal.pone.0146372. eCollection 2016.


Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation.

Hu W, Jain A, Gao Y, Dozmorov IM, Mandraju R, Wakeland EK, Pasare C.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13994-9. doi: 10.1073/pnas.1510760112. Epub 2015 Oct 27.


CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.

Rajaiah R, Perkins DJ, Ireland DD, Vogel SN.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6. doi: 10.1073/pnas.1424980112. Epub 2015 Jun 23.


Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity.

Gallo PM, Rapsinski GJ, Wilson RP, Oppong GO, Sriram U, Goulian M, Buttaro B, Caricchio R, Gallucci S, Tükel Ç.

Immunity. 2015 Jun 16;42(6):1171-84. doi: 10.1016/j.immuni.2015.06.002.


In vitro immunomodulation for enhancing T cell-based diagnosis of Mycobacterium tuberculosis infection.

Slater M, Tran MC, Platt L, Luu LT, Phan HT, Pham PT, Do TB, Nguyen HT, Gaur RL, Parsonnet J, Cattamanchi A, Luo R, Nahid P, Banaei N.

Diagn Microbiol Infect Dis. 2015 Sep;83(1):41-5. doi: 10.1016/j.diagmicrobio.2015.05.007. Epub 2015 May 19.


A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells.

Santone M, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U.

Hum Vaccin Immunother. 2015;11(8):2038-50. doi: 10.1080/21645515.2015.1027467.


Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways.

Hyun J, Ramos JC, Toomey N, Balachandran S, Lavorgna A, Harhaj E, Barber GN.

J Virol. 2015 May;89(9):4880-93. doi: 10.1128/JVI.02493-14. Epub 2015 Feb 18.


Gene expression profiles identify both MyD88-independent and MyD88-dependent pathways involved in the maturation of dendritic cells mediated by heparan sulfate: a novel adjuvant.

Wu M, Wang H, Shi J, Sun J, Duan Z, Li Y, Li J, Hu N, Wei Y, Chen Y, Hu Y.

Hum Vaccin Immunother. 2014;10(12):3711-21. doi: 10.4161/21645515.2014.980682.


Immunostimulatory activity of protein hydrolysate from oviductus ranae on macrophage in vitro.

Huang D, Yang L, Wang C, Ma S, Cui L, Huang S, Sheng X, Weng Q, Xu M.

Evid Based Complement Alternat Med. 2014;2014:180234. doi: 10.1155/2014/180234. Epub 2014 Dec 22.


Characterization of TRIF selectivity in the AGP class of lipid A mimetics: role of secondary lipid chains.

Khalaf JK, Bowen WS, Bazin HG, Ryter KT, Livesay MT, Ward JR, Evans JT, Johnson DA.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):547-53. doi: 10.1016/j.bmcl.2014.12.024. Epub 2014 Dec 17.


STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre ML, Gajewski TF.

Immunity. 2014 Nov 20;41(5):830-42. doi: 10.1016/j.immuni.2014.10.017. Epub 2014 Nov 5. Erratum in: Immunity. 2015 Jan 20;42(1):199.

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