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TAB1-Induced Autoactivation of p38α Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185.

Thapa D, Nichols C, Bassi R, Martin ED, Verma S, Conte MR, De Santis V, De Nicola GF, Marber MS.

Mol Cell Biol. 2018 Feb 12;38(5). pii: e00409-17. doi: 10.1128/MCB.00409-17. Print 2018 Mar 1.


POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NF-κB pathway.

Weng T, Koh CG.

Cell Death Dis. 2017 Sep 14;8(9):e3051. doi: 10.1038/cddis.2017.443.


Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats.

Rafie K, Raimi O, Ferenbach AT, Borodkin VS, Kapuria V, van Aalten DMF.

Open Biol. 2017 Jun;7(6). pii: 170078. doi: 10.1098/rsob.170078.


p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner.

Cong Q, Jia H, Li P, Qiu S, Yeh J, Wang Y, Zhang ZL, Ao J, Li B, Liu H.

Sci Rep. 2017 Apr 6;7:45964. doi: 10.1038/srep45964.


Post-Translational Modifications of the TAK1-TAB Complex.

Hirata Y, Takahashi M, Morishita T, Noguchi T, Matsuzawa A.

Int J Mol Sci. 2017 Jan 19;18(1). pii: E205. doi: 10.3390/ijms18010205. Review.


Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication.

Pang J, Zhang G, Lin Y, Xie Z, Liu H, Tang L, Lu M, Yan R, Guo H, Sun J, Hou J, Zhang X.

Sci Rep. 2017 Jan 3;7:39901. doi: 10.1038/srep39901.


Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways.

McGuire VA, Rosner D, Ananieva O, Ross EA, Elcombe SE, Naqvi S, van den Bosch MM, Monk CE, Ruiz-Zorrilla Diez T, Clark AR, Arthur JS.

Mol Cell Biol. 2016 Dec 19;37(1). pii: e00454-16. Print 2017 Jan 1.


RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.

Gu M, Liu Z, Lai R, Liu S, Lin W, Ouyang C, Ye S, Huang H, Wang X.

EMBO J. 2016 Dec 1;35(23):2553-2565. Epub 2016 Oct 17.


TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.

Pattison MJ, Mitchell O, Flynn HR, Chen CS, Yang HT, Ben-Addi H, Boeing S, Snijders AP, Ley SC.

Biochem J. 2016 Sep 15;473(18):2845-61. doi: 10.1042/BCJ20160502. Epub 2016 Jul 11.


The Role of p38 MAPK in the Development of Diabetic Cardiomyopathy.

Wang S, Ding L, Ji H, Xu Z, Liu Q, Zheng Y.

Int J Mol Sci. 2016 Jun 30;17(7). pii: E1037. doi: 10.3390/ijms17071037. Review.


p38β Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261.

Beenstock J, Melamed D, Mooshayef N, Mordechay D, Garfinkel BP, Ahn NG, Admon A, Engelberg D.

Mol Cell Biol. 2016 May 2;36(10):1540-54. doi: 10.1128/MCB.01105-15. Print 2016 May 15.


p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.

Cong Q, Jia H, Biswas S, Li P, Qiu S, Deng Q, Guo X, Ma G, Ling Chau JF, Wang Y, Zhang ZL, Jiang X, Liu H, Li B.

Stem Cell Reports. 2016 Apr 12;6(4):566-578. doi: 10.1016/j.stemcr.2016.02.001. Epub 2016 Mar 3.


Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197.

De Buck S, Hueber W, Vitaliti A, Straube F, Emotte C, Bruin G, Woessner R.

CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700. doi: 10.1002/psp4.12037. Epub 2015 Nov 9.


Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials.

Fiore M, Forli S, Manetti F.

J Med Chem. 2016 Apr 28;59(8):3609-34. doi: 10.1021/acs.jmedchem.5b01457. Epub 2015 Nov 9. Review.


Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.

Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J.

J Cell Biol. 2015 Sep 28;210(7):1117-31. doi: 10.1083/jcb.201504007. Epub 2015 Sep 21.


Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity.

Ozcan L, Xu X, Deng SX, Ghorpade DS, Thomas T, Cremers S, Hubbard B, Serrano-Wu MH, Gaestel M, Landry DW, Tabas I.

Diabetes. 2015 Oct;64(10):3396-405. doi: 10.2337/db14-1945. Epub 2015 Jun 11.


p38δ MAPK: Emerging Roles of a Neglected Isoform.

O'Callaghan C, Fanning LJ, Barry OP.

Int J Cell Biol. 2014;2014:272689. doi: 10.1155/2014/272689. Epub 2014 Sep 17. Review.


Regulation of toll-like receptors-mediated inflammation by immunobiotics in bovine intestinal epitheliocytes: role of signaling pathways and negative regulators.

Villena J, Aso H, Kitazawa H.

Front Immunol. 2014 Sep 2;5:421. doi: 10.3389/fimmu.2014.00421. eCollection 2014. Review.


Post-translational regulation of mitogen-activated protein kinase phosphatase (MKP)-1 and MKP-2 in macrophages following lipopolysaccharide stimulation: the role of the C termini of the phosphatases in determining their stability.

Crowell S, Wancket LM, Shakibi Y, Xu P, Xue J, Samavati L, Nelin LD, Liu Y.

J Biol Chem. 2014 Oct 17;289(42):28753-64. doi: 10.1074/jbc.M114.591925. Epub 2014 Sep 9.

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