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Items: 11


Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid.

Walther T, Topham CM, Irague R, Auriol C, Baylac A, Cordier H, Dressaire C, Lozano-Huguet L, Tarrat N, Martineau N, Stodel M, Malbert Y, Maestracci M, Huet R, André I, Remaud-Siméon M, François JM.

Nat Commun. 2017 Jun 20;8:15828. doi: 10.1038/ncomms15828.


Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus.

Dahal GP, Viola RE.

Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):36-44. doi: 10.1107/S2053230X16020070. Epub 2017 Jan 1.


Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species.

Li Q, Mu Z, Zhao R, Dahal G, Viola RE, Liu T, Jin Q, Cui S.

Sci Rep. 2016 Feb 12;6:21067. doi: 10.1038/srep21067.


Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.

Thangavelu B, Bhansali P, Viola RE.

Bioorg Med Chem. 2015 Oct 15;23(20):6622-31. doi: 10.1016/j.bmc.2015.09.017. Epub 2015 Sep 9.


Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action.

Huo L, Davis I, Liu F, Andi B, Esaki S, Iwaki H, Hasegawa Y, Orville AM, Liu A.

Nat Commun. 2015 Jan 7;6:5935. doi: 10.1038/ncomms6935.


Structural basis for a bispecific NADP+ and CoA binding site in an archaeal malonyl-coenzyme A reductase.

Demmer U, Warkentin E, Srivastava A, Kockelkorn D, Pötter M, Marx A, Fuchs G, Ermler U.

J Biol Chem. 2013 Mar 1;288(9):6363-70. doi: 10.1074/jbc.M112.421263. Epub 2013 Jan 16.


Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase.

Luniwal A, Wang L, Pavlovsky A, Erhardt PW, Viola RE.

Bioorg Med Chem. 2012 May 1;20(9):2950-6. doi: 10.1016/j.bmc.2012.03.013. Epub 2012 Mar 10.


The catalytic machinery of a key enzyme in amino Acid biosynthesis.

Viola RE, Faehnle CR, Blanco J, Moore RA, Liu X, Arachea BT, Pavlovsky AG.

J Amino Acids. 2011;2011:352538. doi: 10.4061/2011/352538. Epub 2010 Dec 22.


Structural characterization of inhibitors with selectivity against members of a homologous enzyme family.

Pavlovsky AG, Liu X, Faehnle CR, Potente N, Viola RE.

Chem Biol Drug Des. 2012 Jan;79(1):128-36. doi: 10.1111/j.1747-0285.2011.01267.x. Epub 2011 Nov 28.


Isolation and characterization of a novel lysine racemase from a soil metagenomic library.

Chen IC, Lin WD, Hsu SK, Thiruvengadam V, Hsu WH.

Appl Environ Microbiol. 2009 Aug;75(15):5161-6. doi: 10.1128/AEM.00074-09. Epub 2009 Jun 5. Erratum in: Appl Environ Microbiol. 2009 Sep;75(18):6026.


Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis.

Vyas R, Kumar V, Panjikar S, Karthikeyan S, Kishan KV, Tewari R, Weiss MS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Mar 1;64(Pt 3):167-70. doi: 10.1107/S1744309108002753. Epub 2008 Feb 23.

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