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Items: 1 to 20 of 70

1.

Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization.

Charbel Issa P, Barnard AR, Herrmann P, Washington I, MacLaren RE.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8415-20. doi: 10.1073/pnas.1506960112.

2.

Molecular pharmacodynamics of emixustat in protection against retinal degeneration.

Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K.

J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950.

3.

Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage.

Li Y, Yu S, Duncan T, Li Y, Liu P, Gene E, Cortes-Pena Y, Qian H, Dong L, Redmond TM.

Hum Mol Genet. 2015 Aug 1;24(15):4417-28. doi: 10.1093/hmg/ddv178.

4.

Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity.

Bavik C, Henry SH, Zhang Y, Mitts K, McGinn T, Budzynski E, Pashko A, Lieu KL, Zhong S, Blumberg B, Kuksa V, Orme M, Scott I, Fawzi A, Kubota R.

PLoS One. 2015 May 13;10(5):e0124940. doi: 10.1371/journal.pone.0124940.

5.

Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.

Arango-Gonzalez B, Trifunović D, Sahaboglu A, Kranz K, Michalakis S, Farinelli P, Koch S, Koch F, Cottet S, Janssen-Bienhold U, Dedek K, Biel M, Zrenner E, Euler T, Ekström P, Ueffing M, Paquet-Durand F.

PLoS One. 2014 Nov 13;9(11):e112142. doi: 10.1371/journal.pone.0112142.

6.

Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrity.

Hoyo NL, López-Begines S, Rosa JL, Chen J, Méndez A.

PLoS Genet. 2014 Jul 24;10(7):e1004480. doi: 10.1371/journal.pgen.1004480. Erratum in: PLoS Genet. 2014 Oct;10(10):e1004744.

7.

Constitutively active rhodopsin and retinal disease.

Park PS.

Adv Pharmacol. 2014;70:1-36. doi: 10.1016/B978-0-12-417197-8.00001-8. Review.

9.

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.

Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ.

J Neurosci. 2013 Sep 11;33(37):14939-48. doi: 10.1523/JNEUROSCI.0909-13.2013.

10.

Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.

Lobanova ES, Finkelstein S, Skiba NP, Arshavsky VY.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9986-91. doi: 10.1073/pnas.1305521110.

11.

Meckelin 3 is necessary for photoreceptor outer segment development in rat Meckel syndrome.

Tiwari S, Hudson S, Gattone VH 2nd, Miller C, Chernoff EA, Belecky-Adams TL.

PLoS One. 2013;8(3):e59306. doi: 10.1371/journal.pone.0059306.

12.

Kinetic, energetic, and mechanical differences between dark-state rhodopsin and opsin.

Kawamura S, Gerstung M, Colozo AT, Helenius J, Maeda A, Beerenwinkel N, Park PS, Müller DJ.

Structure. 2013 Mar 5;21(3):426-37. doi: 10.1016/j.str.2013.01.011.

13.

Retina, retinol, retinal and the natural history of vitamin A as a light sensor.

Zhong M, Kawaguchi R, Kassai M, Sun H.

Nutrients. 2012 Dec 19;4(12):2069-96. doi: 10.3390/nu4122069. Review.

14.

Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement.

Cideciyan AV, Jacobson SG, Beltran WA, Sumaroka A, Swider M, Iwabe S, Roman AJ, Olivares MB, Schwartz SB, Komáromy AM, Hauswirth WW, Aguirre GD.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E517-25. doi: 10.1073/pnas.1218933110.

15.

QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles.

Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K.

Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):455-66. doi: 10.1167/iovs.12-11152.

16.

Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.

Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K.

J Clin Invest. 2013 Jan;123(1):121-37. doi: 10.1172/JCI66176.

17.

Provitamin A metabolism and functions in mammalian biology.

von Lintig J.

Am J Clin Nutr. 2012 Nov;96(5):1234S-44S. doi: 10.3945/ajcn.112.034629. Review.

18.

Differential proteomics and functional research following gene therapy in a mouse model of Leber congenital amaurosis.

Zheng Q, Ren Y, Tzekov R, Zhang Y, Chen B, Hou J, Zhao C, Zhu J, Zhang Y, Dai X, Ma S, Li J, Pang J, Qu J, Li W.

PLoS One. 2012;7(8):e44855. doi: 10.1371/journal.pone.0044855.

19.

Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis.

Zhang T, Baehr W, Fu Y.

Invest Ophthalmol Vis Sci. 2012 Jun 5;53(7):3349-56. doi: 10.1167/iovs.12-9851.

20.

Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment.

Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH.

J Biol Chem. 2012 May 11;287(20):16424-34. doi: 10.1074/jbc.M112.353763.

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