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Calmodulin and PI3K Signaling in KRAS Cancers.

Nussinov R, Wang G, Tsai CJ, Jang H, Lu S, Banerjee A, Zhang J, Gaponenko V.

Trends Cancer. 2017 Mar;3(3):214-224. doi: 10.1016/j.trecan.2017.01.007. Epub 2017 Feb 18.


The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.

Warren KJ, Fang X, Gowda NM, Thompson JJ, Heller NM.

J Biol Chem. 2016 Nov 25;291(48):24922-24930. Epub 2016 Oct 14.


Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells.

Zhang W, Chen L, Ma K, Zhao Y, Liu X, Wang Y, Liu M, Liang S, Zhu H, Xu N.

Oncotarget. 2016 Nov 15;7(46):75366-75378. doi: 10.18632/oncotarget.12207.


The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.

Lykken EA, Li QJ.

J Biol Chem. 2016 Nov 4;291(45):23532-23544. Epub 2016 Sep 15.


Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells.

Najem D, Bamji-Mirza M, Yang Z, Zhang W.

Neurosci Bull. 2016 Jun;32(3):227-38. doi: 10.1007/s12264-016-0034-9. Epub 2016 May 20.


Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.

Ozoe A, Sone M, Fukushima T, Kataoka N, Chida K, Asano T, Hakuno F, Takahashi S.

Front Endocrinol (Lausanne). 2014 Mar 4;5:24. doi: 10.3389/fendo.2014.00024. eCollection 2014.


Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.

Roberts CK, Hevener AL, Barnard RJ.

Compr Physiol. 2013 Jan;3(1):1-58. doi: 10.1002/cphy.c110062. Review.


mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.

Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E.

Mol Cell. 2012 Dec 28;48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8.


Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.

Stamper BD, Mecham B, Park SS, Wilkerson H, Farin FM, Beyer RP, Bammler TK, Mangravite LM, Cunningham ML.

Physiol Genomics. 2012 Dec 1;44(23):1154-63. doi: 10.1152/physiolgenomics.00085.2012. Epub 2012 Oct 16.


Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S.

J Biol Chem. 2012 Aug 24;287(35):29713-21. doi: 10.1074/jbc.M112.393074. Epub 2012 Jul 5.


Nuclear IRS-1 and cancer.

Reiss K, Del Valle L, Lassak A, Trojanek J.

J Cell Physiol. 2012 Aug;227(8):2992-3000. doi: 10.1002/jcp.24019. Review.


Pathogenesis of insulin resistance in skeletal muscle.

Abdul-Ghani MA, DeFronzo RA.

J Biomed Biotechnol. 2010;2010:476279. doi: 10.1155/2010/476279. Epub 2010 Apr 26. Review.


Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.

DeFronzo RA.

Diabetologia. 2010 Jul;53(7):1270-87. doi: 10.1007/s00125-010-1684-1. Epub 2010 Apr 2. Review.


Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma.

McCampbell AS, Harris HA, Crabtree JS, Winneker RC, Walker CL, Broaddus RR.

Cancer Prev Res (Phila). 2010 Mar;3(3):290-300. doi: 10.1158/1940-6207.CAPR-09-0199. Epub 2010 Feb 23.


Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats.

Zheng Y, Zhang W, Pendleton E, Leng S, Wu J, Chen R, Sun XJ.

J Endocrinol. 2009 Dec;203(3):337-47. doi: 10.1677/JOE-09-0181. Epub 2009 Oct 2.


Parathyroid hormone suppresses insulin signaling in adipocytes.

Chang E, Donkin SS, Teegarden D.

Mol Cell Endocrinol. 2009 Aug 13;307(1-2):77-82. doi: 10.1016/j.mce.2009.03.024. Epub 2009 Apr 9.


Insulin receptor substrates (IRSs) and breast tumorigenesis.

Chan BT, Lee AV.

J Mammary Gland Biol Neoplasia. 2008 Dec;13(4):415-22. doi: 10.1007/s10911-008-9101-9. Epub 2008 Nov 22. Review.


Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor.

Allister EM, Mulvihill EE, Barrett PH, Edwards JY, Carter LP, Huff MW.

J Lipid Res. 2008 Oct;49(10):2218-29. doi: 10.1194/jlr.M800297-JLR200. Epub 2008 Jun 27.


Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

Yamamoto A, Cremona ML, Rothman JE.

J Cell Biol. 2006 Feb 27;172(5):719-31.


Morphine induces desensitization of insulin receptor signaling.

Li Y, Eitan S, Wu J, Evans CJ, Kieffer B, Sun X, Polakiewicz RD.

Mol Cell Biol. 2003 Sep;23(17):6255-66.

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