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β2 Agonists.

Billington CK, Penn RB, Hall IP.

Handb Exp Pharmacol. 2017;237:23-40. doi: 10.1007/164_2016_64.


Beta-Adrenergic Agonists.

Barisione G, Baroffio M, Crimi E, Brusasco V.

Pharmaceuticals (Basel). 2010 Mar 30;3(4):1016-1044. Review.


Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner.

Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA Jr.

Br J Pharmacol. 2016 Sep;173(18):2726-38. doi: 10.1111/bph.13542. Epub 2016 Aug 3.


Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells.

Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB.

PLoS One. 2015 Jun 29;10(6):e0131582. doi: 10.1371/journal.pone.0131582. eCollection 2015.


Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.

Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB.

FASEB J. 2015 Oct;29(10):4227-35. doi: 10.1096/fj.15-273094. Epub 2015 Jun 23.


LAMA/LABA vs ICS/LABA in the treatment of COPD in Japan based on the disease phenotypes.

Hizawa N.

Int J Chron Obstruct Pulmon Dis. 2015 Jun 10;10:1093-102. doi: 10.2147/COPD.S72858. eCollection 2015. Review.


IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism.

Albano GD, Zhao J, Etling EB, Park SY, Hu H, Trudeau JB, Profita M, Wenzel SE.

J Allergy Clin Immunol. 2015 May;135(5):1144-53.e1-9. doi: 10.1016/j.jaci.2015.02.006. Epub 2015 Mar 24.


Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma.

Liggett SB.

Trans Am Clin Climatol Assoc. 2014;125:64-74; discussion 74-5.


Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors.

de Paiva AC, Marson FA, Ribeiro JD, Bertuzzo CS.

Allergy Asthma Clin Immunol. 2014 Feb 5;10(1):8. doi: 10.1186/1710-1492-10-8.


Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells.

Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RA Jr, Liggett SB.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):678-83. doi: 10.1165/rcmb.2013-0439RC.


The anti-asthma herbal medicine ASHMI acutely inhibits airway smooth muscle contraction via prostaglandin E2 activation of EP2/EP4 receptors.

Srivastava K, Sampson HA, Emala CW Sr, Li XM.

Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L1002-10. doi: 10.1152/ajplung.00423.2012. Epub 2013 Oct 25.


Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle.

Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart AD, Penn RB.

FASEB J. 2014 Feb;28(2):956-65. doi: 10.1096/fj.13-240226. Epub 2013 Oct 16.


Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction.

Lazarinis N, Jørgensen L, Ekström T, Bjermer L, Dahlén B, Pullerits T, Hedlin G, Carlsen KH, Larsson K.

Thorax. 2014 Feb;69(2):130-6. doi: 10.1136/thoraxjnl-2013-203557. Epub 2013 Oct 3.


Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators.

Liggett SB.

Expert Opin Ther Targets. 2013 Jun;17(6):721-31. doi: 10.1517/14728222.2013.782395. Epub 2013 Apr 12. Review.


Assessment of murine lung mechanics outcome measures: alignment with those made in asthmatics.

Walker JK, Kraft M, Fisher JT.

Front Physiol. 2013 Feb 12;3:491. doi: 10.3389/fphys.2012.00491. eCollection 2012.


Airway hyperresponsiveness in asthma: mechanisms, clinical significance, and treatment.

Brannan JD, Lougheed MD.

Front Physiol. 2012 Dec 10;3:460. doi: 10.3389/fphys.2012.00460. eCollection 2012.


TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.

An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA Jr, Liggett SB.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L304-11. doi: 10.1152/ajplung.00126.2012. Epub 2012 Jun 8.


C-027 inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways.

Cooper PR, Zhang J, Damera G, Hoshi T, Zopf DA, Panettieri RA Jr.

Allergy Asthma Proc. 2011 Sep-Oct;32(5):359-65. doi: 10.2500/aap.2011.32.3460.


Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.

Lin R, Degan S, Theriot BS, Fischer BM, Strachan RT, Liang J, Pierce RA, Sunday ME, Noble PW, Kraft M, Brody AR, Walker JK.

Br J Pharmacol. 2012 Apr;165(7):2365-77. doi: 10.1111/j.1476-5381.2011.01725.x.


Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.

Nino G, Hu A, Grunstein JS, Grunstein MM.

J Allergy Clin Immunol. 2010 May;125(5):1020-7. doi: 10.1016/j.jaci.2010.02.007. Epub 2010 Apr 14.

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