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Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer.

Wang X, Zhu Q, Lin Y, Wu L, Wu X, Wang K, He Q, Xu C, Wan X, Wang X.

Br J Cancer. 2017 Oct 24;117(9):1371-1382. doi: 10.1038/bjc.2017.297. Epub 2017 Sep 12.


Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.

Leppänen VM, Saharinen P, Alitalo K.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4376-4381. doi: 10.1073/pnas.1616166114. Epub 2017 Apr 10.


Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.

Moore JO, Lemmon MA, Ferguson KM.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4382-4387. doi: 10.1073/pnas.1617800114. Epub 2017 Apr 10.


Angiogenesis in the atherosclerotic plaque.

Camaré C, Pucelle M, Nègre-Salvayre A, Salvayre R.

Redox Biol. 2017 Aug;12:18-34. doi: 10.1016/j.redox.2017.01.007. Epub 2017 Feb 1. Review.


Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.

Eklund L, Kangas J, Saharinen P.

Clin Sci (Lond). 2017 Jan 1;131(1):87-103. Review.


Tie1 controls angiopoietin function in vascular remodeling and inflammation.

Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P.

J Clin Invest. 2016 Sep 1;126(9):3495-510. doi: 10.1172/JCI84923. Epub 2016 Aug 22.


Transcriptional Profiling of Cultured, Embryonic Epicardial Cells Identifies Novel Genes and Signaling Pathways Regulated by TGFβR3 In Vitro.

DeLaughter DM, Clark CR, Christodoulou DC, Seidman CE, Baldwin HS, Seidman JG, Barnett JV.

PLoS One. 2016 Aug 9;11(8):e0159710. doi: 10.1371/journal.pone.0159710. eCollection 2016.


Rescue Effects and Underlying Mechanisms of Intragland Shh Gene Delivery on Irradiation-Induced Hyposalivation.

Hai B, Zhao Q, Qin L, Rangaraj D, Gutti VR, Liu F.

Hum Gene Ther. 2016 May;27(5):390-9. doi: 10.1089/hum.2016.005.


Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.

Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L224-31. doi: 10.1152/ajplung.00336.2015. Epub 2015 Dec 11.


The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation.

Milam KE, Parikh SM.

Tissue Barriers. 2015 Apr 3;3(1-2):e957508. doi: 10.4161/21688362.2014.957508. eCollection 2015.


Alliance A091103 a phase II study of the angiopoietin 1 and 2 peptibody trebananib for the treatment of angiosarcoma.

D' Angelo SP, Mahoney MR, Van Tine BA, Adkins DR, Perdekamp MT, Condy MM, Luke JJ, Hartley EW, Antonescu CR, Tap WD, Schwartz GK.

Cancer Chemother Pharmacol. 2015 Mar;75(3):629-38. doi: 10.1007/s00280-015-2689-8. Epub 2015 Feb 12.


Tie1 is required for lymphatic valve and collecting vessel development.

Qu X, Zhou B, Scott Baldwin H.

Dev Biol. 2015 Mar 1;399(1):117-28. doi: 10.1016/j.ydbio.2014.12.021. Epub 2015 Jan 7.


Targeting the Angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference.

Biel NM, Siemann DW.

Cancer Lett. 2016 Oct 1;380(2):525-33. doi: 10.1016/j.canlet.2014.09.035. Epub 2014 Oct 12. Review.


Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.

D'Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Eklund L, Sormunen R, Elamaa H, Brekken RA, Adams RH, Koh GY, Saharinen P, Alitalo K.

J Clin Invest. 2014 Feb;124(2):824-34. doi: 10.1172/JCI68897. Epub 2014 Jan 16.


Receptor tyrosine kinase-mediated angiogenesis.

Jeltsch M, Leppänen VM, Saharinen P, Alitalo K.

Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a009183. doi: 10.1101/cshperspect.a009183. Review.


Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS.

Parikh SM.

Virulence. 2013 Aug 15;4(6):517-24. doi: 10.4161/viru.24906. Epub 2013 May 7. Review.


Vascular repair and regeneration as a therapeutic target for pulmonary arterial hypertension.

Farkas L, Kolb M.

Respiration. 2013;85(5):355-64. doi: 10.1159/000350177. Epub 2013 Mar 22. Review.


Role of Tie1 in shear stress and atherosclerosis.

Woo KV, Baldwin HS.

Trends Cardiovasc Med. 2011 May;21(4):118-23. doi: 10.1016/j.tcm.2012.03.009. Review.


Inhibition of endothelial/smooth muscle cell contact loss by the investigational angiopoietin-2 antibody MEDI3617.

Molnar N, Siemann DW.

Microvasc Res. 2012 May;83(3):290-7. doi: 10.1016/j.mvr.2012.02.008. Epub 2012 Feb 23.


The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.

Singh H, Hansen TM, Patel N, Brindle NP.

PLoS One. 2012;7(1):e29319. doi: 10.1371/journal.pone.0029319. Epub 2012 Jan 3.

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