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Items: 1 to 20 of 21

1.

Gene, Stem Cell, and Alternative Therapies for SCA 1.

Wagner JL, O'Connor DM, Donsante A, Boulis NM.

Front Mol Neurosci. 2016 Aug 12;9:67. doi: 10.3389/fnmol.2016.00067. eCollection 2016. Review.

2.

Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.

Ingram M, Wozniak EAL, Duvick L, Yang R, Bergmann P, Carson R, O'Callaghan B, Zoghbi HY, Henzler C, Orr HT.

Neuron. 2016 Mar 16;89(6):1194-1207. doi: 10.1016/j.neuron.2016.02.011. Epub 2016 Mar 3.

3.

HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.

Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S, Okazawa H.

EMBO Mol Med. 2015 Jan;7(1):78-101. doi: 10.15252/emmm.201404392.

4.

Mapping the self-association domains of ataxin-1: identification of novel non overlapping motifs.

Menon RP, Soong D, de Chiara C, Holt M, McCormick JE, Anilkumar N, Pastore A.

PeerJ. 2014 Mar 25;2:e323. doi: 10.7717/peerj.323. eCollection 2014.

5.

Kaleidoscopic protein-protein interactions in the life and death of ataxin-1: new strategies against protein aggregation.

de Chiara C, Pastore A.

Trends Neurosci. 2014 Apr;37(4):211-8. doi: 10.1016/j.tins.2014.02.003. Epub 2014 Mar 11. Review.

6.

Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.

Matilla-Dueñas A, Ashizawa T, Brice A, Magri S, McFarland KN, Pandolfo M, Pulst SM, Riess O, Rubinsztein DC, Schmidt J, Schmidt T, Scoles DR, Stevanin G, Taroni F, Underwood BR, Sánchez I.

Cerebellum. 2014 Apr;13(2):269-302. doi: 10.1007/s12311-013-0539-y.

7.

Protein-protein interactions as a strategy towards protein-specific drug design: the example of ataxin-1.

de Chiara C, Menon RP, Kelly G, Pastore A.

PLoS One. 2013 Oct 14;8(10):e76456. doi: 10.1371/journal.pone.0076456. eCollection 2013.

8.

Chemical shift assignment of the ataxin-1 AXH domain in complex with a CIC ligand peptide.

de Chiara C, Kelly G, Menon RP, McCormick J, Pastore A.

Biomol NMR Assign. 2014 Oct;8(2):325-7. doi: 10.1007/s12104-013-9509-z. Epub 2013 Jul 14.

9.

RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1.

Keiser MS, Geoghegan JC, Boudreau RL, Lennox KA, Davidson BL.

Neurobiol Dis. 2013 Aug;56:6-13. doi: 10.1016/j.nbd.2013.04.003. Epub 2013 Apr 10.

10.

Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.

de Chiara C, Rees M, Menon RP, Pauwels K, Lawrence C, Konarev PV, Svergun DI, Martin SR, Chen YW, Pastore A.

Biophys J. 2013 Mar 19;104(6):1304-13. doi: 10.1016/j.bpj.2013.01.048. Epub 2013 Mar 19.

11.

FOX-2 dependent splicing of ataxin-2 transcript is affected by ataxin-1 overexpression.

Welzel F, Kaehler C, Isau M, Hallen L, Lehrach H, Krobitsch S.

PLoS One. 2012;7(5):e37985. doi: 10.1371/journal.pone.0037985. Epub 2012 May 30.

12.

Cell biology of spinocerebellar ataxia.

Orr HT.

J Cell Biol. 2012 Apr 16;197(2):167-77. doi: 10.1083/jcb.201105092. Review.

13.

14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus.

Lai S, O'Callaghan B, Zoghbi HY, Orr HT.

J Biol Chem. 2011 Oct 7;286(40):34606-16. doi: 10.1074/jbc.M111.238527. Epub 2011 Aug 11. Erratum in: J Biol Chem. 2013 Mar 1;288(9):6590.

14.

Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.

Gehrking KM, Andresen JM, Duvick L, Lough J, Zoghbi HY, Orr HT.

Hum Mol Genet. 2011 Jun 1;20(11):2204-12. doi: 10.1093/hmg/ddr108. Epub 2011 Mar 22.

15.

Functional interactions as a survival strategy against abnormal aggregation.

Masino L, Nicastro G, Calder L, Vendruscolo M, Pastore A.

FASEB J. 2011 Jan;25(1):45-54. doi: 10.1096/fj.10-161208. Epub 2010 Sep 1.

16.

Nuclear ataxias.

Orr HT.

Cold Spring Harb Perspect Biol. 2010 May;2(5):a000786. doi: 10.1101/cshperspect.a000786. Review.

17.

Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.

de Chiara C, Menon RP, Strom M, Gibson TJ, Pastore A.

PLoS One. 2009 Dec 23;4(12):e8372. doi: 10.1371/journal.pone.0008372.

18.

Characterization of the zebrafish atxn1/axh gene family.

Carlson KM, Melcher L, Lai S, Zoghbi HY, Clark HB, Orr HT.

J Neurogenet. 2009;23(3):313-23. doi: 10.1080/01677060802399976. Epub 2008 Dec 10.

19.

Pathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1.

Zoghbi HY, Orr HT.

J Biol Chem. 2009 Mar 20;284(12):7425-9. doi: 10.1074/jbc.R800041200. Epub 2008 Oct 28. Review.

20.

The HBP1 transcriptional repressor participates in RAS-induced premature senescence.

Zhang X, Kim J, Ruthazer R, McDevitt MA, Wazer DE, Paulson KE, Yee AS.

Mol Cell Biol. 2006 Nov;26(22):8252-66. Epub 2006 Sep 11.

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