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Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer.

Lozada EM, Andrysik Z, Yin M, Redilla N, Rice K, Stambrook PJ.

Oncotarget. 2016 Apr 12;7(15):20425-39. doi: 10.18632/oncotarget.7966.


Telekin suppresses human hepatocellular carcinoma cells in vitro by inducing G2/M phase arrest via the p38 MAPK signaling pathway.

Li L, Zheng BB, Ma LS, Sun X, Chang JJ, Xie WD, Li X.

Acta Pharmacol Sin. 2014 Oct;35(10):1311-22. doi: 10.1038/aps.2014.74. Epub 2014 Sep 1.


CRL Ubiquitin Ligases and DNA Damage Response.

Li JM, Jin J.

Front Oncol. 2012 Apr 9;2:29. doi: 10.3389/fonc.2012.00029. eCollection 2012.


Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.

Goloudina AR, Mazur SJ, Appella E, Garrido C, Demidov ON.

Cell Cycle. 2012 May 15;11(10):1883-7. doi: 10.4161/cc.19901. Epub 2012 May 15.


Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.

Ma CX, Cai S, Li S, Ryan CE, Guo Z, Schaiff WT, Lin L, Hoog J, Goiffon RJ, Prat A, Aft RL, Ellis MJ, Piwnica-Worms H.

J Clin Invest. 2012 Apr;122(4):1541-52. doi: 10.1172/JCI58765. Epub 2012 Mar 26. Erratum in: J Clin Invest. 2012 Jul 2;122(7):2702.


Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells.

Origanti S, Cai SR, Munir AZ, White LS, Piwnica-Worms H.

Oncogene. 2013 Jan 31;32(5):577-88. doi: 10.1038/onc.2012.84. Epub 2012 Mar 19.


Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.

Zhao H, Chen X, Gurian-West M, Roberts JM.

Mol Cell Biol. 2012 Apr;32(8):1421-32. doi: 10.1128/MCB.06721-11. Epub 2012 Feb 13.


A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

Blasius M, Forment JV, Thakkar N, Wagner SA, Choudhary C, Jackson SP.

Genome Biol. 2011 Aug 18;12(8):R78. doi: 10.1186/gb-2011-12-8-r78.


Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.

Kittipatarin C, Li W, Durum SK, Khaled AR.

Exp Hematol. 2010 Dec;38(12):1143-56. doi: 10.1016/j.exphem.2010.08.010. Epub 2010 Sep 8.


Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain.

Chou ST, Yen YC, Lee CM, Chen MS.

J Biol Chem. 2010 Jun 4;285(23):17833-45. doi: 10.1074/jbc.M109.078386. Epub 2010 Apr 5.


Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.

Honaker Y, Piwnica-Worms H.

Oncogene. 2010 Jun 10;29(23):3324-34. doi: 10.1038/onc.2010.96. Epub 2010 Mar 29.


microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.

Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J.

Cancer Res. 2009 Oct 15;69(20):8157-65. doi: 10.1158/0008-5472.CAN-09-1996. Epub 2009 Oct 13.


DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.

Leung-Pineda V, Huh J, Piwnica-Worms H.

Cancer Res. 2009 Mar 15;69(6):2630-7. doi: 10.1158/0008-5472.CAN-08-3382. Epub 2009 Mar 10.


Non-classical p38 map kinase functions: cell cycle checkpoints and survival.

Thornton TM, Rincon M.

Int J Biol Sci. 2009;5(1):44-51. Epub 2008 Dec 19. Review.


Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition.

Tomko RJ Jr, Azang-Njaah NN, Lazo JS.

Cell Cycle. 2009 Jan 15;8(2):299-305. Epub 2009 Jan 10.


In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets.

Kiyokawa H, Ray D.

Anticancer Agents Med Chem. 2008 Dec;8(8):832-6. Review.


Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis.

Shreeram S, Hee WK, Bulavin DV.

Mol Cell Biol. 2008 Dec;28(24):7442-50. doi: 10.1128/MCB.00138-08. Epub 2008 Oct 20.


Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.

Jin J, Ang XL, Ye X, Livingstone M, Harper JW.

J Biol Chem. 2008 Jul 11;283(28):19322-8. doi: 10.1074/jbc.M802474200. Epub 2008 May 13.


GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.

Kang T, Wei Y, Honaker Y, Yamaguchi H, Appella E, Hung MC, Piwnica-Worms H.

Cancer Cell. 2008 Jan;13(1):36-47. doi: 10.1016/j.ccr.2007.12.002.

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