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Items: 19


Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation.

Ni D, Song K, Zhang J, Lu S.

Int J Mol Sci. 2017 Oct 26;18(11). pii: E2249. doi: 10.3390/ijms18112249.


From phenologs to silent suppressors: Identifying potential therapeutic targets for human disease.

Golden A.

Mol Reprod Dev. 2017 Nov;84(11):1118-1132. doi: 10.1002/mrd.22880. Epub 2017 Oct 3. Review.


Enhanced MAPK signaling is essential for CSF3R-induced leukemia.

Rohrabaugh S, Kesarwani M, Kincaid Z, Huber E, Leddonne J, Siddiqui Z, Khalifa Y, Komurov K, Grimes HL, Azam M.

Leukemia. 2017 Aug;31(8):1770-1778. doi: 10.1038/leu.2016.376. Epub 2016 Dec 27.


AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.

Fisher KW, Das B, Kim HS, Clymer BK, Gehring D, Smith DR, Costanzo-Garvey DL, Fernandez MR, Brattain MG, Kelly DL, MacMillan J, White MA, Lewis RE.

Mol Cell Biol. 2015 Nov;35(22):3866-79. doi: 10.1128/MCB.00528-15. Epub 2015 Sep 8.


Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer.

Zhang H, Angelopoulos N, Xu Y, Grothey A, Nunes J, Stebbing J, Giamas G.

Breast Cancer Res Treat. 2015 Jun;151(3):555-68. doi: 10.1007/s10549-015-3443-y. Epub 2015 May 29.


The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis.

Echrish H, Madden LA, Greenman J, Maraveyas A.

Cancers (Basel). 2011 Jan 11;3(1):267-84. doi: 10.3390/cancers3010267.


SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1.

Zhang H, Xu Y, Filipovic A, Lit LC, Koo CY, Stebbing J, Giamas G.

Br J Cancer. 2013 Nov 12;109(10):2675-84. doi: 10.1038/bjc.2013.628. Epub 2013 Oct 15.


Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis.

Gramling MW, Eischen CM.

Cell Death Differ. 2012 Jul;19(7):1220-7. doi: 10.1038/cdd.2012.1. Epub 2012 Feb 3.


Raf family kinases: old dogs have learned new tricks.

Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W.

Genes Cancer. 2011 Mar;2(3):232-60. doi: 10.1177/1947601911407323.


Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.

Yang Z, Chen M, Sitarski SA, Saadatzadeh T, Yin F, Yu M, Yang FC, Chan RJ.

Leuk Res. 2011 Jul;35(7):961-4. doi: 10.1016/j.leukres.2011.04.003. Epub 2011 May 8.


KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.

Llobet D, Eritja N, Domingo M, Bergada L, Mirantes C, Santacana M, Pallares J, Macià A, Yeramian A, Encinas M, Moreno-Bueno G, Palacios J, Lewis RE, Matias-Guiu X, Dolcet X.

Am J Pathol. 2011 Apr;178(4):1529-43. doi: 10.1016/j.ajpath.2010.12.041.


A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation.

Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Physiol Biochem. 2009;24(3-4):219-30. doi: 10.1159/000233248. Epub 2009 Aug 3.


Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake.

Zhang J, Zafrullah M, Yang X, Yin X, Zhang Z, Fuks Z, Kolesnick R.

Cancer Biol Ther. 2008 Sep;7(9):1490-5. Epub 2008 Sep 15.


Pancreatic cancer.

Maitra A, Hruban RH.

Annu Rev Pathol. 2008;3:157-88. Review.


The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.

Kortum RL, Johnson HJ, Costanzo DL, Volle DJ, Razidlo GL, Fusello AM, Shaw AS, Lewis RE.

Mol Cell Biol. 2006 Mar;26(6):2202-14.


Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation.

Yan F, John SK, Wilson G, Jones DS, Washington MK, Polk DB.

J Clin Invest. 2004 Nov;114(9):1272-80.


Inflammatory bowel disease reveals the kinase activity of KSR1.

Kolesnick R, Xing HR.

J Clin Invest. 2004 Nov;114(9):1233-7. Review.

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