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Items: 20


Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat.

Taskar KS, Mariappan TT, Kurawattimath V, Singh Gautam S, Radhakrishna Mullapudi TV, Sridhar SK, Kallem RR, Marathe P, Mandlekar S.

J Cent Nerv Syst Dis. 2017 Mar 15;9:1179573517693596. doi: 10.1177/1179573517693596. eCollection 2017.


Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs.

Ravikumar Reddy D, Khurana A, Bale S, Ravirala R, Samba Siva Reddy V, Mohankumar M, Godugu C.

Springerplus. 2016 Sep 20;5(1):1618. doi: 10.1186/s40064-016-3267-1. eCollection 2016.


Sustained Accumulation of Microtubule-Binding Chemotherapy Drugs in the Peripheral Nervous System: Correlations with Time Course and Neurotoxic Severity.

Wozniak KM, Vornov JJ, Wu Y, Nomoto K, Littlefield BA, DesJardins C, Yu Y, Lai G, Reyderman L, Wong N, Slusher BS.

Cancer Res. 2016 Jun 1;76(11):3332-9. doi: 10.1158/0008-5472.CAN-15-2525. Epub 2016 Apr 13.


Carotid artery infusions for pharmacokinetic and pharmacodynamic analysis of taxanes in mice.

Jacobs JD, Hopper-Borge EA.

J Vis Exp. 2014 Oct 27;(92):e51917. doi: 10.3791/51917.


P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model.

Adkins CE, Mittapalli RK, Manda VK, Nounou MI, Mohammad AS, Terrell TB, Bohn KA, Yasemin C, Grothe TR, Lockman JA, Lockman PR.

Front Pharmacol. 2013 Nov 4;4:136. doi: 10.3389/fphar.2013.00136. eCollection 2013.


Paclitaxel Nano-Delivery Systems: A Comprehensive Review.

Ma P, Mumper RJ.

J Nanomed Nanotechnol. 2013 Feb 18;4(2):1000164.


2'-Behenoyl-paclitaxel conjugate containing lipid nanoparticles for the treatment of metastatic breast cancer.

Ma P, Rahima Benhabbour S, Feng L, Mumper RJ.

Cancer Lett. 2013 Jul 1;334(2):253-62. doi: 10.1016/j.canlet.2012.08.009. Epub 2012 Aug 16.


Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model.

Wang X, Duan X, Yang G, Zhang X, Deng L, Zheng H, Deng C, Wen J, Wang N, Peng C, Zhao X, Wei Y, Chen L.

PLoS One. 2011 Apr 29;6(4):e18490. doi: 10.1371/journal.pone.0018490.


Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.

Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB 3rd, Huryn DM.

Curr Top Med Chem. 2011;11(3):317-30. Review.


Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.

Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, Huang S, Palmieri D, Steeg PS, Smith QR.

Clin Cancer Res. 2010 Dec 1;16(23):5664-78. doi: 10.1158/1078-0432.CCR-10-1564. Epub 2010 Sep 9.


Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors.

Wang F, Zhou F, Kruh GD, Gallo JM.

Neuro Oncol. 2010 Oct;12(10):1043-9. doi: 10.1093/neuonc/noq056. Epub 2010 May 25.


Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas.

Carcaboso AM, Elmeliegy MA, Shen J, Juel SJ, Zhang ZM, Calabrese C, Tracey L, Waters CM, Stewart CF.

Cancer Res. 2010 Jun 1;70(11):4499-508. doi: 10.1158/0008-5472.CAN-09-4264. Epub 2010 May 11.


Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Klaassen CD, Aleksunes LM.

Pharmacol Rev. 2010 Mar;62(1):1-96. doi: 10.1124/pr.109.002014. Epub 2010 Jan 26. Review.


Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer.

Thomas FC, Taskar K, Rudraraju V, Goda S, Thorsheim HR, Gaasch JA, Mittapalli RK, Palmieri D, Steeg PS, Lockman PR, Smith QR.

Pharm Res. 2009 Nov;26(11):2486-94. doi: 10.1007/s11095-009-9964-5. Epub 2009 Sep 23.


New strategies to deliver anticancer drugs to brain tumors.

Laquintana V, Trapani A, Denora N, Wang F, Gallo JM, Trapani G.

Expert Opin Drug Deliv. 2009 Oct;6(10):1017-32. doi: 10.1517/17425240903167942. Review.


Investigation of the influence of FcRn on the distribution of IgG to the brain.

Garg A, Balthasar JP.

AAPS J. 2009 Sep;11(3):553-7. doi: 10.1208/s12248-009-9129-9. Epub 2009 Jul 28.


In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate.

Ballatore C, Zhang B, Trojanowski JQ, Lee VM, Smith AB 3rd.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6119-21. doi: 10.1016/j.bmcl.2008.10.024. Epub 2008 Oct 10.


Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2.

Régina A, Demeule M, Ché C, Lavallée I, Poirier J, Gabathuler R, Béliveau R, Castaigne JP.

Br J Pharmacol. 2008 Sep;155(2):185-97. doi: 10.1038/bjp.2008.260. Epub 2008 Jun 23.


Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry.

Guo P, Wang X, Liu L, Belinsky MG, Kruh GD, Gallo JM.

J Pharm Biomed Anal. 2007 Apr 11;43(5):1789-95. Epub 2007 Jan 12.

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