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Items: 1 to 20 of 149


Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease.

Tan VTY, Mockett BG, Ohline SM, Parfitt KD, Wicky HE, Peppercorn K, Schoderboeck L, Yahaya MFB, Tate WP, Hughes SM, Abraham WC.

Mol Brain. 2018 Feb 9;11(1):7. doi: 10.1186/s13041-018-0348-9.


Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis.

Pinchi E, Frati A, Cipolloni L, Aromatario M, Gatto V, La Russa R, Pesce A, Santurro A, Fraschetti F, Frati P, Fineschi V.

Sci Rep. 2018 Feb 5;8(1):2387. doi: 10.1038/s41598-018-20699-1.


Secreted gelsolin desensitizes and induces apoptosis of infiltrated lymphocytes in prostate cancer.

Chen CC, Chiou SH, Yang CL, Chow KC, Lin TY, Chang HW, You WC, Huang HW, Chen CM, Chen NC, Chou FP, Chou MC.

Oncotarget. 2017 Aug 23;8(44):77152-77167. doi: 10.18632/oncotarget.20414. eCollection 2017 Sep 29.


Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?

Li JM, Huang LL, Liu F, Tang BS, Yan XX.

BMC Neurol. 2017 Aug 25;17(1):163. doi: 10.1186/s12883-017-0942-y.


Filling the void: a role for exercise-induced BDNF and brain amyloid precursor protein processing.

MacPherson REK.

Am J Physiol Regul Integr Comp Physiol. 2017 Nov 1;313(5):R585-R593. doi: 10.1152/ajpregu.00255.2017. Epub 2017 Aug 16. Review.


Amyloid beta: structure, biology and structure-based therapeutic development.

Chen GF, Xu TH, Yan Y, Zhou YR, Jiang Y, Melcher K, Xu HE.

Acta Pharmacol Sin. 2017 Sep;38(9):1205-1235. doi: 10.1038/aps.2017.28. Epub 2017 Jul 17. Review.


The Role of APP in Structural Spine Plasticity.

Montagna E, Dorostkar MM, Herms J.

Front Mol Neurosci. 2017 May 10;10:136. doi: 10.3389/fnmol.2017.00136. eCollection 2017. Review.


Elongation affinity, activation barrier, and stability of Aβ42 oligomers/fibrils in physiological saline.

Rodriguez RA, Chen LY, Plascencia-Villa G, Perry G.

Biochem Biophys Res Commun. 2017 May 27;487(2):444-449. doi: 10.1016/j.bbrc.2017.04.084. Epub 2017 Apr 17.


Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.

Mukherjee S, Russell JC, Carr DT, Burgess JD, Allen M, Serie DJ, Boehme KL, Kauwe JSK, Naj AC, Fardo DW, Dickson DW, Montine TJ, Ertekin-Taner N, Kaeberlein MR, Crane PK.

Alzheimers Dement. 2017 Oct;13(10):1133-1142. doi: 10.1016/j.jalz.2017.01.016. Epub 2017 Feb 24.


Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα.

Mockett BG, Richter M, Abraham WC, Müller UC.

Front Mol Neurosci. 2017 Feb 7;10:30. doi: 10.3389/fnmol.2017.00030. eCollection 2017. Review.


Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.

Copenhaver PF, Kögel D.

Front Mol Neurosci. 2017 Jan 31;10:3. doi: 10.3389/fnmol.2017.00003. eCollection 2017. Review.


Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity.

Ludewig S, Korte M.

Front Mol Neurosci. 2017 Jan 20;9:161. doi: 10.3389/fnmol.2016.00161. eCollection 2016. Review.


Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?

Hunter S, Brayne C.

J Negat Results Biomed. 2017 Jan 26;16(1):1. doi: 10.1186/s12952-017-0066-3. Review. Erratum in: J Negat Results Biomed. 2017 Mar 8;16(1):8.


Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer's Disease Mouse Model.

Guo C, Yang ZH, Zhang S, Chai R, Xue H, Zhang YH, Li JY, Wang ZY.

Neuropsychopharmacology. 2017 Dec;42(13):2504-2515. doi: 10.1038/npp.2017.8. Epub 2017 Jan 12.


Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway.

Li S, Wang X, Ma QH, Yang WL, Zhang XG, Dawe GS, Xiao ZC.

Sci Rep. 2016 Dec 23;6:39320. doi: 10.1038/srep39320.


Role of Drosophila Amyloid Precursor Protein in Memory Formation.

Preat T, Goguel V.

Front Mol Neurosci. 2016 Dec 8;9:142. doi: 10.3389/fnmol.2016.00142. eCollection 2016. Review.


Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus.

Del Turco D, Paul MH, Schlaudraff J, Hick M, Endres K, Müller UC, Deller T.

Front Mol Neurosci. 2016 Nov 29;9:134. eCollection 2016.


Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.

Ramaker JM, Cargill RS, Swanson TL, Quirindongo H, Cassar M, Kretzschmar D, Copenhaver PF.

Front Mol Neurosci. 2016 Nov 25;9:130. eCollection 2016.


Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders.

Ikonomovic MD, Mi Z, Abrahamson EE.

Ageing Res Rev. 2017 Mar;34:51-63. doi: 10.1016/j.arr.2016.11.003. Epub 2016 Nov 6. Review.


Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic.

Suliman NA, Mat Taib CN, Mohd Moklas MA, Adenan MI, Hidayat Baharuldin MT, Basir R.

Evid Based Complement Alternat Med. 2016;2016:4391375. doi: 10.1155/2016/4391375. Epub 2016 Aug 30. Review.

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