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Items: 1 to 20 of 28

1.

Combined Targeting of mTOR and Akt Using Rapamycin and MK-2206 in The Treatment of Tuberous Sclerosis Complex.

Ji S, Lin W, Wang L, Ni Z, Jin F, Zha X, Fei G.

J Cancer. 2017 Feb 11;8(4):555-562. doi: 10.7150/jca.17205. eCollection 2017.

2.

A central role for a region in the middle.

Stuttfeld E, Imseng S, Maier T.

Elife. 2017 Mar 7;6. pii: e25700. doi: 10.7554/eLife.25700.

3.

Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation.

Velásquez C, Cheng E, Shuda M, Lee-Oesterreich PJ, Pogge von Strandmann L, Gritsenko MA, Jacobs JM, Moore PS, Chang Y.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8466-71. doi: 10.1073/pnas.1607768113. Epub 2016 Jul 11.

4.

Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae.

Worley J, Sullivan A, Luo X, Kaplan ME, Capaldi AP.

G3 (Bethesda). 2015 Dec 17;6(2):463-74. doi: 10.1534/g3.115.025882.

5.

GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes.

Chen XL, Serrano D, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S.

PLoS One. 2015 Oct 6;10(10):e0139019. doi: 10.1371/journal.pone.0139019. eCollection 2015.

6.

Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response.

Ayuso MI, Martinez-Alonso E, Salvador N, Bonova P, Regidor I, Alcázar A.

PLoS One. 2015 Mar 30;10(3):e0121958. doi: 10.1371/journal.pone.0121958. eCollection 2015.

7.

Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1.

Szymańska P, Martin KR, MacKeigan JP, Hlavacek WS, Lipniacki T.

PLoS One. 2015 Mar 11;10(3):e0116550. doi: 10.1371/journal.pone.0116550. eCollection 2015.

8.

mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions.

Showkat M, Beigh MA, Andrabi KI.

Mol Biol Int. 2014;2014:686984. doi: 10.1155/2014/686984. Epub 2014 Nov 20. Review.

9.

Inhibition of mammalian target of rapamycin by rapamycin increases the radiosensitivity of esophageal carcinoma Eca109 cells.

Zhang D, Xiang J, Gu Y, Xu W, Xu H, Zu M, Pei D, Zheng J.

Oncol Lett. 2014 Aug;8(2):575-581. Epub 2014 May 27.

10.

Role of mTOR inhibitor in cholangiocarcinoma cell progression.

Moolthiya P, Tohtong R, Keeratichamroen S, Leelawat K.

Oncol Lett. 2014 Mar;7(3):854-860. Epub 2014 Jan 15.

11.

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding.

Livingstone M, Bidinosti M.

F1000Res. 2012 Jul 18;1:4. doi: 10.12688/f1000research.1-4.v1. eCollection 2012.

12.

Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.

Loganathan S, Kandala PK, Gupta P, Srivastava SK.

PLoS One. 2012;7(8):e43577. doi: 10.1371/journal.pone.0043577. Epub 2012 Aug 27.

13.

4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1.

Shang ZF, Yu L, Li B, Tu WZ, Wang Y, Liu XD, Guan H, Huang B, Rang WQ, Zhou PK.

Cell Cycle. 2012 Sep 15;11(18):3463-71. doi: 10.4161/cc.21770. Epub 2012 Aug 23.

14.

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM.

Sci Signal. 2012 Jun 12;5(228):ra42. doi: 10.1126/scisignal.2002790.

15.

The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.

Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.

J Biol Chem. 2011 Nov 4;286(44):38043-53. doi: 10.1074/jbc.M111.245449. Epub 2011 Sep 13.

16.

ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Cohen JD, Gard JM, Nagle RB, Dietrich JD, Monks TJ, Lau SS.

Toxicol Sci. 2011 Nov;124(1):75-87. doi: 10.1093/toxsci/kfr203. Epub 2011 Aug 2.

17.

The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS.

Gosselin P, Oulhen N, Jam M, Ronzca J, Cormier P, Czjzek M, Cosson B.

Nucleic Acids Res. 2011 Apr;39(8):3496-503. doi: 10.1093/nar/gkq1306. Epub 2010 Dec 22.

18.

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling.

Tato I, Bartrons R, Ventura F, Rosa JL.

J Biol Chem. 2011 Feb 25;286(8):6128-42. doi: 10.1074/jbc.M110.166991. Epub 2010 Dec 3.

19.

New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress.

Ayuso MI, Hernández-Jiménez M, Martín ME, Salinas M, Alcázar A.

J Biol Chem. 2010 Nov 5;285(45):34355-63. doi: 10.1074/jbc.M110.135103. Epub 2010 Aug 24.

20.

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