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Items: 8


The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs.

Stams TR, Bourgonje VJ, Beekman HD, Schoenmakers M, van der Nagel R, Oosterhoff P, van Opstal JM, Vos MA.

Br J Pharmacol. 2014 Feb;171(3):714-22. doi: 10.1111/bph.12483.


Increased sarcolemmal Na(+)/H(+) exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block.

van Borren MM, Vos MA, Houtman MJ, Antoons G, Ravesloot JH.

Front Physiol. 2013 Nov 26;4:322. doi: 10.3389/fphys.2013.00322. eCollection 2013.


Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.

Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA.

Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x.


Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart.

Takahara A, Nakamura Y, Wagatsuma H, Aritomi S, Nakayama A, Satoh Y, Akie Y, Sugiyama A.

Br J Pharmacol. 2009 Nov;158(5):1366-74. doi: 10.1111/j.1476-5381.2009.00407.x. Epub 2009 Sep 28.


Isoproterenol disperses distribution of NADPH oxidase, MMP-9, and pPKCepsilon in the heart, which are mitigated by endothelin receptor antagonist CPU0213.

Cheng YS, Dai DZ, Dai Y.

Acta Pharmacol Sin. 2009 Aug;30(8):1099-106. doi: 10.1038/aps.2009.104. Epub 2009 Jul 13.


Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears.

Nelson OL, Robbins CT, Wu Y, Granzier H.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H366-71. doi: 10.1152/ajpheart.00234.2008. Epub 2008 May 23.


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