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Items: 1 to 20 of 26


Significance of the E3 ubiquitin protein UBR5 as an oncogene and a prognostic biomarker in colorectal cancer.

Xie Z, Liang H, Wang J, Xu X, Zhu Y, Guo A, Shen X, Cao F, Chang W.

Oncotarget. 2017 Nov 20;8(64):108079-108092. doi: 10.18632/oncotarget.22531. eCollection 2017 Dec 8.


Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.

Matsuura K, Huang NJ, Cocce K, Zhang L, Kornbluth S.

Oncogene. 2017 Mar 23;36(12):1698-1706. doi: 10.1038/onc.2016.336. Epub 2016 Oct 10.


Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.

Landré V, Rotblat B, Melino S, Bernassola F, Melino G.

Oncotarget. 2014 Sep 30;5(18):7988-8013. Review.


Potential Urinary miRNA Biomarker Candidates for the Accurate Detection of Prostate Cancer among Benign Prostatic Hyperplasia Patients.

Haj-Ahmad TA, Abdalla MA, Haj-Ahmad Y.

J Cancer. 2014 Jan 29;5(3):182-91. doi: 10.7150/jca.6799. eCollection 2014.


Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity.

Bolt MJ, Stossi F, Callison AM, Mancini MG, Dandekar R, Mancini MA.

Oncogene. 2015 Jan 8;34(2):154-64. doi: 10.1038/onc.2013.550. Epub 2014 Jan 20.


Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.

Ong SS, Goktug AN, Elias A, Wu J, Saunders D, Chen T.

Biochem J. 2014 Apr 1;459(1):193-203. doi: 10.1042/BJ20130558.


EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.

Bradley A, Zheng H, Ziebarth A, Sakati W, Branham-O'Connor M, Blumer JB, Liu Y, Kistner-Griffin E, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Landen CN Jr, Eblen ST.

Carcinogenesis. 2014 May;35(5):1100-9. doi: 10.1093/carcin/bgt489. Epub 2013 Dec 30.


Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites.

Bartocci C, Denchi EL.

Front Genet. 2013 Jul 9;4:128. doi: 10.3389/fgene.2013.00128. eCollection 2013.


The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.

Benavides M, Chow-Tsang LF, Zhang J, Zhong H.

Biochim Biophys Acta. 2013 Jan;1833(1):21-32. doi: 10.1016/j.bbamcr.2012.10.007. Epub 2012 Oct 12.


Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase.

Matta-Camacho E, Kozlov G, Menade M, Gehring K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1158-63. doi: 10.1107/S1744309112036937. Epub 2012 Sep 22.


Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines.

Justiniano SE, Mathew A, Mitra S, Manivannan SN, Simcox A.

PLoS One. 2012;7(2):e31417. doi: 10.1371/journal.pone.0031417. Epub 2012 Feb 21.


A novel potent tumour promoter aberrantly overexpressed in most human cancers.

Takahashi A, Tokita H, Takahashi K, Takeoka T, Murayama K, Tomotsune D, Ohira M, Iwamatsu A, Ohara K, Yazaki K, Koda T, Nakagawara A, Tani K.

Sci Rep. 2011;1:15. doi: 10.1038/srep00015. Epub 2011 Jun 14. Erratum in: Sci Rep. 2013;3:49.


A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis.

Dompe N, Rivers CS, Li L, Cordes S, Schwickart M, Punnoose EA, Amler L, Seshagiri S, Tang J, Modrusan Z, Davis DP.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E943-51. doi: 10.1073/pnas.1100132108. Epub 2011 Sep 26.


EDD inhibits ATM-mediated phosphorylation of p53.

Ling S, Lin WC.

J Biol Chem. 2011 Apr 29;286(17):14972-82. doi: 10.1074/jbc.M110.182527. Epub 2011 Mar 7.


Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD.

Tomaic V, Pim D, Thomas M, Massimi P, Myers MP, Banks L.

J Virol. 2011 Apr;85(7):3120-7. doi: 10.1128/JVI.02004-10. Epub 2011 Jan 12.


Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

Cojocaru M, Bouchard A, Cloutier P, Cooper JJ, Varzavand K, Price DH, Coulombe B.

J Biol Chem. 2011 Feb 18;286(7):5012-22. doi: 10.1074/jbc.M110.176628. Epub 2010 Dec 2.


The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin.

Hay-Koren A, Caspi M, Zilberberg A, Rosin-Arbesfeld R.

Mol Biol Cell. 2011 Feb 1;22(3):399-411. doi: 10.1091/mbc.E10-05-0440. Epub 2010 Nov 30.


Modulation of myocardin function by the ubiquitin E3 ligase UBR5.

Hu G, Wang X, Saunders DN, Henderson M, Russell AJ, Herring BP, Zhou J.

J Biol Chem. 2010 Apr 16;285(16):11800-9. doi: 10.1074/jbc.M109.079384. Epub 2010 Feb 18. Erratum in: J Biol Chem. 2011 Jul 15;286(28):25416.


Copy number gain and oncogenic activity of YWHAZ/14-3-3zeta in head and neck squamous cell carcinoma.

Lin M, Morrison CD, Jones S, Mohamed N, Bacher J, Plass C.

Int J Cancer. 2009 Aug 1;125(3):603-11. doi: 10.1002/ijc.24346.

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